Enhanced Production of Neuroprogenitors, Dopaminergic Neurons, and Identification of Target Genes by Overexpression of Sonic Hedgehog in Human Embryonic Stem Cells

2012 ◽  
Vol 21 (5) ◽  
pp. 729-741 ◽  
Author(s):  
Selena Meiyun Wu ◽  
Ker Sin Tan ◽  
Huishan Chen ◽  
Thian Thian Beh ◽  
Hock Chuan Yeo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Sonic Hedgehog ◽  
Human Embryonic Stem Cells ◽  
Dopaminergic Neurons ◽  
Target Genes ◽  
Embryonic Stem ◽  
Enhanced Production

scholarly journals Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells

Development ◽  
2009 ◽  
Vol 136 (23) ◽  
pp. 4055-4063 ◽  
Author(s):  
X.-J. Li ◽  
X. Zhang ◽  
M. A. Johnson ◽  
Z.-B. Wang ◽  
T. LaVaute ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Sonic Hedgehog ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem

scholarly journals Impact of AHR Ligand TCDD on Human Embryonic Stem Cells and Early Differentiation

2020 ◽  
Vol 21 (23) ◽  
pp. 9052
Author(s):  
Indrek Teino ◽  
Antti Matvere ◽  
Martin Pook ◽  
Inge Varik ◽  
Laura Pajusaar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Target Genes ◽  
Expression Patterns ◽  
Embryonic Stem ◽  
Stem Cell Differentiation ◽  
Cell Types ◽  
Early Differentiation

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, which mediates the effects of a variety of environmental stimuli in multiple tissues. Recent advances in AHR biology have underlined its importance in cells with high developmental potency, including pluripotent stem cells. Nonetheless, there is little data on AHR expression and its role during the initial stages of stem cell differentiation. The purpose of this study was to investigate the temporal pattern of AHR expression during directed differentiation of human embryonic stem cells (hESC) into neural progenitor, early mesoderm and definitive endoderm cells. Additionally, we investigated the effect of the AHR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the gene expression profile in hESCs and differentiated cells by RNA-seq, accompanied by identification of AHR binding sites by ChIP-seq and epigenetic landscape analysis by ATAC-seq. We showed that AHR is differentially regulated in distinct lineages. We provided evidence that TCDD alters gene expression patterns in hESCs and during early differentiation. Additionally, we identified novel potential AHR target genes, which expand our understanding on the role of this protein in different cell types.

Human Embryonic Stem Cells, Dopaminergic Neurons, and Pathways for Developing a Parkinson's Disease Therapy

2007 ◽  
pp. 523-544 ◽  
Author(s):  
William J. Freed ◽  
Joseph F. Sanchez ◽  
Chun-Ting Lee ◽  
Tandis Vazin ◽  
Rose Amable ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Dopaminergic Neurons ◽  
Embryonic Stem ◽  
Disease Therapy

scholarly journals A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: Studies in vitro and in vivo

2007 ◽  
Vol 1127 ◽  
pp. 19-25 ◽  
Author(s):  
Lorraine Iacovitti ◽  
Angela E. Donaldson ◽  
Cheryl E. Marshall ◽  
Sokreine Suon ◽  
Ming Yang
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Dopaminergic Neurons ◽  
Embryonic Stem

Efficient Differentiation of Human Embryonic Stem Cells Toward Dopaminergic Neurons Using Recombinant LMX1A Factor

2014 ◽  
Vol 57 (2) ◽  
pp. 184-194 ◽  
Author(s):  
Ali Fathi ◽  
Hassan Rasouli ◽  
Meghdad Yeganeh ◽  
Ghassem Hosseini Salekdeh ◽  
Hossein Baharvand
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Dopaminergic Neurons ◽  
Embryonic Stem

scholarly journals The transcription factor TFCP2L1 induces expression of distinct target genes and promotes self-renewal of mouse and human embryonic stem cells

2019 ◽  
Vol 294 (15) ◽  
pp. 6007-6016 ◽  
Author(s):  
Xiaohu Wang ◽  
Xiaoxiao Wang ◽  
Shuyuan Zhang ◽  
Hongwei Sun ◽  
Sijia Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Transcription Factor ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Target Genes ◽  
Embryonic Stem ◽  
Self Renewal
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