scholarly journals Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells

Development ◽  
2009 ◽  
Vol 136 (23) ◽  
pp. 4055-4063 ◽  
Author(s):  
X.-J. Li ◽  
X. Zhang ◽  
M. A. Johnson ◽  
Z.-B. Wang ◽  
T. LaVaute ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Sonic Hedgehog ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem

scholarly journals Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells

Stem Cells ◽  
2019 ◽  
Vol 38 (3) ◽  
pp. 352-368 ◽  
Author(s):  
Wenbin Liang ◽  
Pengcheng Han ◽  
Elizabeth H. Kim ◽  
Jordan Mak ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Pacemaker Cell ◽  
Canonical Wnt Signaling ◽  
Cell Specification ◽  
Canonical Wnt

scholarly journals Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells

Blood ◽  
2008 ◽  
Vol 111 (1) ◽  
pp. 122-131 ◽  
Author(s):  
Petter S. Woll ◽  
Julie K. Morris ◽  
Matt S. Painschab ◽  
Rebecca K. Marcus ◽  
Aimee D. Kohn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Endothelial Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Human Embryonic Stem Cells ◽  
Stromal Cells ◽  
Hematopoietic Cells ◽  
Embryonic Stem ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

Human embryonic stem cells (hESCs) provide an important means to effectively study soluble and cell-bound mediators that regulate development of early blood and endothelial cells in a human model system. Here, several complementary methods are used to demonstrate canonical Wnt signaling is important for development of hESC-derived cells with both hematopoietic and endothelial potential. Analyses using both standard flow cy-tometry, as well the more detailed high-throughput image scanning flow cytometry, characterizes sequential development of distinct early developing CD34brightCD31+Flk1+ cells and a later population of CD34dimCD45+ cells. While the CD34brightCD31+Flk1+ have a more complex morphology and can develop into both endothelial cells and hematopoietic cells, the CD34dimCD45+ cells have a simpler morphology and give rise to only hematopoietic cells. Treatment with dickkopf1 to inhibit Wnt signaling results in a dramatic decrease in development of cells with hematoendothelial potential. In addition, activation of the canonical Wnt signaling pathway in hESCs by coculture with stromal cells that express Wnt1, but not use of noncanonical Wnt5-expressing stromal cells, results in an accelerated differentiation and higher percentage of CD34brightCD31+Flk1+ cells at earlier stages of differentiation. These studies effectively demonstrate the importance of canonical Wnt signaling to mediate development of early hematoendothelial progenitors during human development.

Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFβ and Wnt signaling

Development ◽  
2015 ◽  
Vol 142 (19) ◽  
pp. 3294-3306 ◽  
Author(s):  
Shufeng Zhou ◽  
Anthony Flamier ◽  
Mohamed Abdouh ◽  
Nicolas Tétreault ◽  
Andrea Barabino ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cone Photoreceptors ◽  
Simultaneous Inhibition

The effect of multivalent Sonic hedgehog on differentiation of human embryonic stem cells into dopaminergic and GABAergic neurons

Biomaterials ◽  
2014 ◽  
Vol 35 (3) ◽  
pp. 941-948 ◽  
Author(s):  
Tandis Vazin ◽  
Randolph S. Ashton ◽  
Anthony Conway ◽  
Nikhil A. Rode ◽  
Susan M. Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Sonic Hedgehog ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Gabaergic Neurons

Enhanced Production of Neuroprogenitors, Dopaminergic Neurons, and Identification of Target Genes by Overexpression of Sonic Hedgehog in Human Embryonic Stem Cells

2012 ◽  
Vol 21 (5) ◽  
pp. 729-741 ◽  
Author(s):  
Selena Meiyun Wu ◽  
Ker Sin Tan ◽  
Huishan Chen ◽  
Thian Thian Beh ◽  
Hock Chuan Yeo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Sonic Hedgehog ◽  
Human Embryonic Stem Cells ◽  
Dopaminergic Neurons ◽  
Target Genes ◽  
Embryonic Stem ◽  
Enhanced Production

scholarly journals Noncanonical Wnt Signaling Orchestrates Early Developmental Events toward Hematopoietic Cell Fate from Human Embryonic Stem Cells

2009 ◽  
Vol 4 (3) ◽  
pp. 248-262 ◽  
Author(s):  
Kausalia Vijayaragavan ◽  
Eva Szabo ◽  
Marc Bossé ◽  
Veronica Ramos-Mejia ◽  
Randall T. Moon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Cell Fate ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Hematopoietic Cell ◽  
Early Developmental

scholarly journals A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells

Development ◽  
2019 ◽  
Vol 146 (6) ◽  
pp. dev172791 ◽  
Author(s):  
Iain Martyn ◽  
Ali H. Brivanlou ◽  
Eric D. Siggia
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Primitive Streak
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