The Significance of Interleukin-6 in the Early Detection of Surgical Site Infections after Definitive Operation for Gastrointestinal Fistulae

2018 ◽  
Vol 19 (5) ◽  
pp. 523-528 ◽  
Author(s):  
Dongming Zhang ◽  
Jianan Ren ◽  
Mohamed-Omar Arafeh ◽  
Robert G. Sawyer ◽  
Qiongyuan Hu ◽  
...  
Keyword(s):  
Early Detection ◽  
Interleukin 6 ◽  
Surgical Site Infections ◽  
Definitive Operation

scholarly journals Concentration standardization improves the capacity of drainage CRP and IL-6 to predict surgical site infections

2020 ◽  
Vol 245 (16) ◽  
pp. 1513-1517
Author(s):  
Xiaoqin Bi ◽  
Yan Li ◽  
Jie Lin ◽  
Chunjie Li ◽  
Jiping Li ◽  
...  
Keyword(s):  
Early Detection ◽  
Interleukin 6 ◽  
Surgical Site Infections ◽  
Inflammatory Factors ◽  
C Reactive Protein ◽  
Diagnostic Efficacy ◽  
Translational Study ◽  
Reactive Protein ◽  
Baseline Levels ◽  
Absolute Concentrations

The early detection of surgical site infection (SSI) remains an unsolved problem. Inflammatory factors in fluids drained from surgical sites may be a promising tool for predicting SSI. Previous attempts to predict SSI via such factors have not taken baseline concentrations into account. However, this may have comprised predictive efficacy. In the current study, concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6) in fluid samples drained from surgical sites in 20 patients with SSI and 60 matched controls were assessed, and concentrations from day 2 to day 4 were divided by the concentration at day 1 to achieve concentration standardization. There were no significant differences of CRP or IL-6 concentrations at day 1 or day 2 ( p >  0.05), but there were significant differences at day 3 and day 4 ( p <  0.05). The areas under the curve (AUCs) for SSI of standardized concentrations were higher than those of the corresponding absolute concentrations of CRP and IL-6 in fluid drained at days 3 and 4. Standardized concentrations of CRP at day 4 yielded the highest AUC (0.92; 95% confidence interval: 0.84–0.97), with a sensitivity of 90% and specificity of 80% at the best cutoff. Concentration standardization may improve the efficacy of predicting SSI via CRP and IL-6 in fluids drained from surgical sites. Although the sample size was small, the study demonstrated the feasibility of non-invasive, accurate, and early detection of postoperative SSI in a diverse real population. Further studies are needed to validate the results of the present study and investigate their broader applicability. Impact statement The ability to predict surgical site infections (SSIs) early would be advantageous. Previous studies have investigated the use of inflammatory factors in fluids drained from surgical sites to predict SSI, but the diagnostic efficacy of this method requires improvement. Baseline levels of inflammatory factors vary between individuals, but this variation tends to differ in patients with and without SSIs. Therefore, we standardized subsequently acquired concentrations of interleukin 6 and C-reactive protein in fluids drained from surgical sites by dividing them by the concentrations determined at day 1 to preclude the confounding effects of differences in baseline levels. The standardized concentrations had higher predictive efficacy than the absolute concentrations. Standardizing the data rendered SSI prediction more precise and practical in a diverse group of real patients. This translational study suggests that inflammatory factors in fluid drained from injury sites are promising tools for the prediction of SSI in the clinic.

Early detection of severe sepsis in the emergency room: Diagnostic value of plasma C-reactive protein, procalcitonin, and interleukin-6

2011 ◽  
Vol 43 (11-12) ◽  
pp. 883-890 ◽  
Author(s):  
Raija Uusitalo-Seppälä ◽  
Pertti Koskinen ◽  
Aila Leino ◽  
Heikki Peuravuori ◽  
Tero Vahlberg ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Early Detection ◽  
Emergency Room ◽  
Interleukin 6 ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals The Role of C-reactive Protein and Interleukin 6 in the Cases of Preeclampsia Associated with Obesity

2019 ◽  
Vol 70 (3) ◽  
pp. 805-808 ◽  
Author(s):  
Izabella Petre ◽  
Marius Craina ◽  
Nicolae Suciu ◽  
Alina Sisu ◽  
Radu Dumitru Moleriu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Early Detection ◽  
Pregnant Women ◽  
Interleukin 6 ◽  
Inflammatory Markers ◽  
Inflammatory Condition ◽  
European Level ◽  
C Reactive Protein ◽  
Reactive Protein

In the management of preeclampsia/eclampsia, it would be useful at least at European level, to have clear protocols for early detection and approach of cases with hypertension, as well as to create an algorithm to identify the predisposition to hypertensive pregnancy pathology. The aim has been to identify the favorable factors and the evolution of the pregnancy in the 100 patients admitted to the obstetrics clinic between January 2014 and December 2018, aged between 15-44 years, who have been diagnosed with preeclampsia. In recent years, the management of pregnant women with preeclampsia has improved a lot due to a better understanding of the pathogenesis and a refinement of adequate pregnancy monitoring. Obesity has been shown to be a risk factor in preeclampsia. Several studies have identified preeclampsia as an inflammatory condition. A large number of inflammatory markers, such as C-reactive protein (PCR) and Interleukin 6 (IL-6), have been shown to be elevated in pregnant women with preeclampsia.

scholarly journals C-Reactive Protein and Interleukin-6 Levels in the Early Detection of Infection after Open Fractures

2012 ◽  
Vol 20 (3) ◽  
pp. 381-385 ◽  
Author(s):  
Balaji Douraiswami ◽  
Patro K Dilip ◽  
BN Harish ◽  
Menon Jagdish
Keyword(s):  
Early Detection ◽  
Interleukin 6 ◽  
Open Fractures ◽  
C Reactive Protein ◽  
Reactive Protein

Early detection of infection in pigs based on interleukin-6 dynamics

2013 ◽  
Vol 28 (6) ◽  
pp. e35
Author(s):  
Tim Tambuyzer ◽  
Tine De Waele ◽  
Daniel Berckmans ◽  
Bruno Goddeeris ◽  
Jean-Marie Aerts
Keyword(s):  
Early Detection ◽  
Interleukin 6

scholarly journals Peritoneal interleukin-6 and tumor necrosis factor-alpha as markers for early detection of anastomotic dehiscence following surgery for colorectal cancer

2019 ◽  
Vol 2 (2) ◽  
pp. 28-32
Author(s):  
Blazenka Ladika Davidovic ◽  
Dubravka Muzina Misic ◽  
Ivan Samija
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Surgery ◽  
Early Detection ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Anastomotic Dehiscence ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

Anastomotic dehiscence is one of the most serious complications following surgery for colorectal cancer, and early detection of anastomotic dehiscence is critical to minimize mortality and morbidity. The aim of this study was to determine the value of peritoneal interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) as markers for preclinical detection of anastomosis dehiscence following colorectal surgery. Concentrations of IL-6 and TNF-α were measured in drain fluid obtained from 58 patients on days 1 to 4 following surgery for colorectal cancer. Five out of 58 patients developed anastomosis dehiscence. Patients who developed anastomosis dehiscence had significantly higher concentration of IL-6 on day 1 after surgery, and TNF-α on day 1, 2 and 4 after surgery. Interleukin-6 on day 1 was predictive for anastomosis dehiscence with specificity of 83%, sensitivity of 80%, positive predictive value (PPV) of 31% and negative predictive value (NPV) of 98%. TNF-α was predictive for anastomosis dehiscence on day 1 (specificity 92%, sensitivity 80%, PPV 50%, NPV 98%), day 2 (specificity 94%, sensitivity 80%, PPV 57%, NPV 98%), and day 4 (specificity 83%, sensitivity 100%, PPV 27%, NPV 100%). Our study indicates the potential use of peritoneal cytokines IL-6 and TNF-α as additional diagnostic tool for early detection of anastomosis dehiscence following colorectal surgery.

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