Large-Scale Production of Human Adipose Tissue from Stem Cells: A New Tool for Regenerative Medicine and Tissue Banking

2008 ◽  
Vol 14 (3) ◽  
pp. 233-242 ◽  
Author(s):  
Francesco D'Andrea ◽  
Francesco De Francesco ◽  
Giuseppe A. Ferraro ◽  
Vincenzo Desiderio ◽  
Virginia Tirino ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Regenerative Medicine ◽  
Large Scale ◽  
Tissue Banking ◽  
Human Adipose Tissue ◽  
Scale Production ◽  
Large Scale Production

Large-Scale Production of Human Adipose Tissue from Stem Cells: A New Tool for Regenerative Medicine and Tissue Banking

2008 ◽  
pp. 110306231138043
Author(s):  
Francesco D'andrea ◽  
Francesco De Francesco ◽  
Giuseppe A. Ferraro ◽  
Vincenzo Desiderio ◽  
Virginia Tirino ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Regenerative Medicine ◽  
Large Scale ◽  
Tissue Banking ◽  
Human Adipose Tissue ◽  
Scale Production ◽  
Large Scale Production

Megakaryocytes and Platelets from Novel Human Adipose Tissue-derived Mesenchymal Stem Cells: Development of Cell-based Regenerative Medicine

2021 ◽  
pp. 989-1003
Author(s):  
Yukako Ono-Uruga ◽  
Keiichi Tozawa ◽  
Yasuo Ikeda ◽  
Yumiko Matsubara
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Regenerative Medicine ◽  
Human Adipose Tissue

scholarly journals Reproducible Large-Scale Isolation of Exosomes from Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells and Their Application in Acute Kidney Injury

2020 ◽  
Vol 21 (13) ◽  
pp. 4774 ◽  
Author(s):  
Jun Ho Lee ◽  
Dae Hyun Ha ◽  
Hyeon-kyu Go ◽  
Jinkwon Youn ◽  
Hyun-keun Kim ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Adipose Tissue ◽  
Stromal Cells ◽  
Large Scale ◽  
Kidney Diseases ◽  
Kidney Injury ◽  
Preclinical Studies ◽  
Scale Production ◽  
Positive Effects ◽  
Large Scale Production

Acute kidney injury (AKI) is a fatal medical episode caused by sudden kidney damage or failure, leading to the death of patients within a few hours or days. Previous studies demonstrated that exosomes derived from various mesenchymal stem/stromal cells (MSC-exosomes) have positive effects on renal injuries in multiple experimental animal models of kidney diseases including AKI. However, the mass production of exosomes is a challenge not only in preclinical studies with large animals but also for successful clinical applications. In this respect, tangential flow filtration (TFF) is suitable for good manufacturing practice (GMP)-compliant large-scale production of high-quality exosomes. Until now, no studies have been reported on the use of TFF, but rather ultracentrifugation has been almost exclusively used, to isolate exosomes for AKI therapeutic application in preclinical studies. Here, we demonstrated the reproducible large-scale production of exosomes derived from adipose tissue-derived MSC (ASC-exosomes) using TFF and the lifesaving effect of the ASC-exosomes in a lethal model of cisplatin-induced rat AKI. Our results suggest the possibility of large-scale stable production of ASC-exosomes without loss of function and their successful application in life-threatening diseases.

scholarly journals Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem Cells

Hepatology ◽  
2020 ◽  
Vol 72 (1) ◽  
pp. 257-270 ◽  
Author(s):  
Kerstin Schneeberger ◽  
Natalia Sánchez‐Romero ◽  
Shicheng Ye ◽  
Frank G. Steenbeek ◽  
Loes A. Oosterhoff ◽  
...  
Keyword(s):  
Stem Cells ◽  
Human Liver ◽  
Large Scale ◽  
Scale Production ◽  
Liver Stem Cells ◽  
Large Scale Production

scholarly journals Bioprocessing strategies for the large-scale production of human mesenchymal stem cells: a review

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Krishna M. Panchalingam ◽  
Sunghoon Jung ◽  
Lawrence Rosenberg ◽  
Leo A. Behie
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Large Scale ◽  
Human Mesenchymal Stem Cells ◽  
Scale Production ◽  
Large Scale Production

Human Adipose Tissue Possesses a Unique Population of Pluripotent Stem Cells with Nontumorigenic and Low Telomerase Activities: Potential Implications in Regenerative Medicine

2014 ◽  
Vol 23 (7) ◽  
pp. 717-728 ◽  
Author(s):  
Fumitaka Ogura ◽  
Shohei Wakao ◽  
Yasumasa Kuroda ◽  
Kenichiro Tsuchiyama ◽  
Mozhdeh Bagheri ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Regenerative Medicine ◽  
Pluripotent Stem Cells ◽  
Human Adipose Tissue

Large-scale production of human mesenchymal stem cells for clinical applications

2012 ◽  
Vol 59 (2) ◽  
pp. 106-120 ◽  
Author(s):  
Sunghoon Jung ◽  
Krishna M. Panchalingam ◽  
Reynold D. Wuerth ◽  
Lawrence Rosenberg ◽  
Leo A. Behie
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Large Scale ◽  
Human Mesenchymal Stem Cells ◽  
Clinical Applications ◽  
Scale Production ◽  
Large Scale Production

scholarly journals A cost-effective and efficient reprogramming platform for large-scale production of integration-free human induced pluripotent stem cells in chemically defined culture

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jeanette Beers ◽  
Kaari L. Linask ◽  
Jane A. Chen ◽  
Lauren I. Siniscalchi ◽  
Yongshun Lin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Large Scale ◽  
Cost Effective ◽  
Scale Production ◽  
Large Scale Production ◽  
Induced Pluripotent ◽  
Defined Culture
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