Cytoplasmic Localization of the Paired Box Gene, Pax-8, is Found in Pediatric Thyroid Cancer and May Be Associated With a Greater Risk of Recurrence

Thyroid ◽  
2004 ◽  
Vol 14 (12) ◽  
pp. 1037-1046 ◽  
Author(s):  
William T. Scouten ◽  
Aneeta Patel ◽  
Richard Terrell ◽  
Henry B. Burch ◽  
Victor J. Bernet ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cytoplasmic Localization ◽  
Risk Of Recurrence ◽  
Pediatric Thyroid Cancer

scholarly journals Ablation rate after radioactive iodine therapy in patients with differentiated thyroid cancer at intermediate or high risk of recurrence: a systematic review and a meta-analysis

2021 ◽  
Author(s):  
Michele Klain ◽  
Carmela Nappi ◽  
Emilia Zampella ◽  
Valeria Cantoni ◽  
Roberta Green ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Cancer ◽  
High Risk ◽  
Differentiated Thyroid Cancer ◽  
Meta Analysis ◽  
Ablation Rate ◽  
Intermediate Risk ◽  
Risk Of Recurrence ◽  
Successful Ablation ◽  
Risk Patients

Abstract Purpose We performed a systematic review and a meta-analysis to investigate the successful ablation rate after radioiodine (RAI) administration in patients with differentiated thyroid cancer (DTC) at intermediate-high risk of recurrence. Methods A comprehensive literature search of the PubMed, Scopus, and Web of Science databases was conducted according to the PRISMA statement. Results The final analysis included 9 studies accounting for 3103 patients at intermediate-high risk of recurrence. In these patients, the successful ablation rates ranged from 51 to 94% with a 71% pooled successful ablation and were higher in intermediate (72%) than in high (52%)-risk patients. Despite the rigorous inclusion standards, a significant heterogeneity among the evaluated studies was observed. Higher administered RAI activities are associated with a lower successful ablation rate in the whole population and in the subgroup of high-risk patients. Furthermore, pooled recurrence rate in intermediate-risk patients achieving successful ablation was only 2% during the subsequent 6.4-year follow-up while the pooled recurrence rate was 14% in patients who did not achieve a successful ablation. Conclusion In a large sample of 3103 patients at intermediate-high risk of persistent/recurrent disease, 71% of patients achieved a successful ablation. In these intermediate-risk patients, the probability of subsequent recurrence is low and most recurrence occurred in those with already abnormal findings at the first control.

scholarly journals Simulation of Post-Thyroidectomy Treatment Alternatives for Triiodothyronine or Thyroxine Replacement in Pediatric Thyroid Cancer Patients

Thyroid ◽  
2012 ◽  
Vol 22 (6) ◽  
pp. 595-603 ◽  
Author(s):  
Rotem Ben-Shachar ◽  
Marisa Eisenberg ◽  
Stephen A. Huang ◽  
Joseph J. DiStefano
Keyword(s):  
Thyroid Cancer ◽  
Cancer Patients ◽  
Thyroxine Replacement ◽  
Treatment Alternatives ◽  
Pediatric Thyroid Cancer

Clinical Analysis of Pediatric Thyroid Cancer: A Single Medical Institution Experience of 18 Years

2019 ◽  
Vol 128 (12) ◽  
pp. 1152-1157 ◽  
Author(s):  
Hyung Kwon Byeon ◽  
Sang Bin Kim ◽  
Hyeon Seok Oh ◽  
Hong Kyu Kim ◽  
In Hak Choi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Thyroid Carcinoma ◽  
Medical Center ◽  
Disease Recurrence ◽  
Clinical Analysis ◽  
Lateral Lymph Node ◽  
Node Metastasis ◽  
Pediatric Thyroid Cancer

Objective: The incidence of pediatric thyroid cancer is relatively low compared to the disease in adults. This study aims to present the data in our institution on pediatric thyroid cancer patients, with particular emphasis on the risk factors of recurrence together with treatment outcomes. Subjects and Methods: Between January 2000 and July 2018, patients <20 years who were diagnosed with thyroid carcinoma and primarily treated with surgery at a major large-volume tertiary medical center specializing in thyroid cancer were enrolled. A total of 83 patients were eligible for this study. Results: The majority of the studied patients were girls and adolescents (age ≥13 years). Papillary thyroid carcinoma (PTC) was the most common pathology (n = 74). PTC tumors >1 cm showed higher rate of lymph node metastasis and extrathyroidal extension than tumors ≤1 cm. All patients survived with nine PTC patients who displayed treatment failure. Age, tumor size, multifocality, lateral lymph node metastasis, and postoperative thyroglobulin levels were significant prognosticators for disease recurrence. Conclusion: Pediatric thyroid cancer is relatively rare and should be considered a specific disease entity with respect to the thyroid cancer in adults, since there are several distinctive characteristics.

A National Perspective of the Risk, Presentation, and Outcomes of Pediatric Thyroid Cancer

2016 ◽  
Vol 142 (5) ◽  
pp. 472 ◽  
Author(s):  
Zaid Al-Qurayshi ◽  
Adam Hauch ◽  
Sudesh Srivastav ◽  
Rizwan Aslam ◽  
Paul Friedlander ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
National Perspective ◽  
Pediatric Thyroid Cancer

Pediatric Thyroid Cancer

2017 ◽  
pp. 125-133
Author(s):  
Melanie Goldfarb ◽  
Trevan Fischer
Keyword(s):  
Thyroid Cancer ◽  
Pediatric Thyroid Cancer

scholarly journals Thyroid Cancer in the Pediatric Population

Genes ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 723 ◽  
Author(s):  
Vera A. Paulson ◽  
Erin R. Rudzinski ◽  
Douglas S. Hawkins
Keyword(s):  
Thyroid Cancer ◽  
Pediatric Population ◽  
Medullary Carcinoma ◽  
High Rate ◽  
Molecular Characteristics ◽  
Thyroid Tumors ◽  
Molecular Alterations ◽  
Stage Disease ◽  
Therapeutic Recommendations ◽  
Pediatric Thyroid Cancer

Thyroid cancer is rare in the pediatric population, but thyroid carcinomas occurring in children carry a unique set of clinical, pathologic, and molecular characteristics. In comparison to adults, children more often present with aggressive, advanced stage disease. This is at least in part due to the underlying biologic and molecular differences between pediatric and adult thyroid cancer. Specifically, papillary thyroid carcinoma (which accounts for approximately 90% of pediatric thyroid cancer) has a high rate of gene fusions which influence the histologic subtypes encountered in pediatric thyroid tumors, are associated with more extensive extrathyroidal disease, and offer unique options for targeted medical therapies. Differences are also seen in pediatric follicular thyroid cancer, although there are few studies of non-papillary pediatric thyroid tumors published in the literature due to their rarity, and in medullary carcinoma, which is most frequently diagnosed in the pediatric population in the setting of prophylactic thyroidectomies for known multiple endocrine neoplasia syndromes. The overall shift in the spectrum of histotypes and underlying molecular alterations common in pediatric thyroid cancer is important to recognize as it may directly influence diagnostic test selection and therapeutic recommendations.

Early postoperative stimulated serum thyroglobulin quantifies risk of recurrence in papillary thyroid cancer

Surgery ◽  
2020 ◽  
Vol 167 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Jayani Jayasekara ◽  
Pascal Jonker ◽  
Jia Feng Lin ◽  
Anton F. Engelsman ◽  
Man-Shun Wong ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Serum Thyroglobulin ◽  
Risk Of Recurrence
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