scholarly journals Centrosomes are required for proper β-catenin processing and Wnt response

2020 ◽  
Vol 31 (17) ◽  
pp. 1951-1961
Author(s):  
Setu M. Vora ◽  
Jan S. Fassler ◽  
Bryan T. Phillips
Keyword(s):  
Cell Signaling ◽  
Wnt Signaling ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Signaling Components

The Wnt/β-catenin pathway is a key cell signaling module utilized in cell fate specification. Recent studies suggest an interplay between Wnt/β-catenin signaling components and centrosome function. This study explores the net effects of centrosome loss on Wnt signaling and posttranslational β-catenin regulation.

scholarly journals Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate

2011 ◽  
Vol 22 (13) ◽  
pp. 2409-2421 ◽  
Author(s):  
Yuri Fonar ◽  
Yoni E. Gutkovich ◽  
Heather Root ◽  
Anastasia Malyarova ◽  
Emil Aamar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wnt Signaling ◽  
Focal Adhesion Kinase ◽  
Cell Fate ◽  
Focal Adhesion ◽  
Control Cell ◽  
Focal Adhesions ◽  
Neural Plate ◽  
Cell Fate Specification ◽  
Fate Specification

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase protein localized to regions called focal adhesions, which are contact points between cells and the extracellular matrix. FAK protein acts as a scaffold to transfer adhesion-dependent and growth factor signals into the cell. Increased FAK expression is linked to aggressive metastatic and invasive tumors. However, little is known about its normal embryonic function. FAK protein knockdown during early Xenopus laevis development anteriorizes the embryo. Morphant embryos express increased levels of anterior neural markers, with reciprocally reduced posterior neural marker expression. Posterior neural plate folding and convergence-extension is also inhibited. This anteriorized phenotype resembles that of embryos knocked down zygotically for canonical Wnt signaling. FAK and Wnt3a genes are both expressed in the neural plate, and Wnt3a expression is FAK dependent. Ectopic Wnt expression rescues this FAK morphant anteriorized phenotype. Wnt3a thus acts downstream of FAK to balance anterior–posterior cell fate specification in the developing neural plate. Wnt3a gene expression is also FAK dependent in human breast cancer cells, suggesting that this FAK–Wnt linkage is highly conserved. This unique observation connects the FAK- and Wnt-signaling pathways, both of which act to promote cancer when aberrantly activated in mammalian cells.

scholarly journals Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1

2017 ◽  
Vol 430 (1) ◽  
pp. 142-155 ◽  
Author(s):  
Kathleen Hübner ◽  
Kathrin S. Grassme ◽  
Jyoti Rao ◽  
Nina K. Wenke ◽  
Cordula L. Zimmer ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Wnt Signaling ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals rBMP represses Wnt signaling and influences skeletal progenitor cell fate specification during bone repair

2010 ◽  
Vol 25 (6) ◽  
pp. 1196-1207 ◽  
Author(s):  
Steve Minear ◽  
Philipp Leucht ◽  
Samara Miller ◽  
Jill A Helms
Keyword(s):  
Wnt Signaling ◽  
Cell Fate ◽  
Progenitor Cell ◽  
Bone Repair ◽  
Cell Fate Specification ◽  
Fate Specification

Sox proteins: regulators of cell fate specification and differentiation

Development ◽  
2013 ◽  
Vol 140 (20) ◽  
pp. 4129-4144 ◽  
Author(s):  
Y. Kamachi ◽  
H. Kondoh
Keyword(s):  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Sox Proteins
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