scholarly journals Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries

PLoS Genetics ◽  
2016 ◽  
Vol 12 (2) ◽  
pp. e1005822 ◽  
Author(s):  
Ai Tian ◽  
Hassina Benchabane ◽  
Zhenghan Wang ◽  
Yashi Ahmed
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Wnt Signaling ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Stem Cell Proliferation

Stem Cell Fate Specification: Role of Master Regulatory Switch Transcription Factor PU.1 in Differential Hematopoiesis

2005 ◽  
Vol 14 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Gurudutta U. Gangenahalli ◽  
Pallavi Gupta ◽  
Daman Saluja ◽  
Yogesh K. Verma ◽  
Vimal Kishore ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Stem Cell Fate ◽  
Fate Specification

scholarly journals Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate

2011 ◽  
Vol 22 (13) ◽  
pp. 2409-2421 ◽  
Author(s):  
Yuri Fonar ◽  
Yoni E. Gutkovich ◽  
Heather Root ◽  
Anastasia Malyarova ◽  
Emil Aamar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wnt Signaling ◽  
Focal Adhesion Kinase ◽  
Cell Fate ◽  
Focal Adhesion ◽  
Control Cell ◽  
Focal Adhesions ◽  
Neural Plate ◽  
Cell Fate Specification ◽  
Fate Specification

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase protein localized to regions called focal adhesions, which are contact points between cells and the extracellular matrix. FAK protein acts as a scaffold to transfer adhesion-dependent and growth factor signals into the cell. Increased FAK expression is linked to aggressive metastatic and invasive tumors. However, little is known about its normal embryonic function. FAK protein knockdown during early Xenopus laevis development anteriorizes the embryo. Morphant embryos express increased levels of anterior neural markers, with reciprocally reduced posterior neural marker expression. Posterior neural plate folding and convergence-extension is also inhibited. This anteriorized phenotype resembles that of embryos knocked down zygotically for canonical Wnt signaling. FAK and Wnt3a genes are both expressed in the neural plate, and Wnt3a expression is FAK dependent. Ectopic Wnt expression rescues this FAK morphant anteriorized phenotype. Wnt3a thus acts downstream of FAK to balance anterior–posterior cell fate specification in the developing neural plate. Wnt3a gene expression is also FAK dependent in human breast cancer cells, suggesting that this FAK–Wnt linkage is highly conserved. This unique observation connects the FAK- and Wnt-signaling pathways, both of which act to promote cancer when aberrantly activated in mammalian cells.

scholarly journals Molecular Mechanisms of Stem Cell Pluripotency and Cell Fate Specification

2017 ◽  
Vol 429 (10) ◽  
pp. 1439-1440
Author(s):  
Greg M. Findlay ◽  
Laurent David ◽  
Tobias A. Beyer
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Molecular Mechanisms ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Stem Cell Pluripotency

Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration

2017 ◽  
Vol 147 (6) ◽  
pp. 749-758 ◽  
Author(s):  
Weiming Qiu ◽  
Mingxing Lei ◽  
Ling Zhou ◽  
Xiufeng Bai ◽  
Xiangdong Lai ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Wnt Signaling ◽  
Hair Follicle ◽  
Stem Cell Proliferation ◽  
Hair Follicle Stem Cell ◽  
Hair Regeneration ◽  
Signaling Activation

T1728 Role of ADAM10 Signaling in Cell Proliferation and Cell Fate Specification is Conserved Between the Developing and Adult Intestine

2010 ◽  
Vol 138 (5) ◽  
pp. S-566 ◽  
Author(s):  
Yu-Hwai Tsai ◽  
Kelli L. VanDussen ◽  
Howard C. Crawford ◽  
Linda C. Samuelson ◽  
Peter J. Dempsey
Keyword(s):  
Cell Proliferation ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals Wnt signaling activation : targets and therapeutic opportunities for stem cell therapy and regenerative medicine

2021 ◽  
Author(s):  
Clémence Bonnet ◽  
Anvi Brahmbhatt ◽  
Sophie Deng ◽  
Jie J. Zheng
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Wnt Signaling ◽  
Tissue Regeneration ◽  
Self Renewal ◽  
Stem Cell Proliferation ◽  
Wnt Proteins ◽  
Signaling Activation

Wnt proteins are secreted morphogens that play critical roles in embryonic development, stem cell proliferation, self-renewal, tissue regeneration and remodeling in adults. While aberrant Wnt signaling contributes to diseases such...

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