Role of Prion Protein During Normal Physiology and Disease

2009 ◽  
pp. 3-20
Author(s):  
Adriana Simon Coitinho ◽  
Glaucia N. M. Hajj
Keyword(s):  
Prion Protein

scholarly journals The Role of Cellular Prion Protein in Cancer Biology: A Potential Therapeutic Target

2021 ◽  
Vol 11 ◽  
Author(s):  
Manqiu Ding ◽  
Yongqiang Chen ◽  
Yue Lang ◽  
Li Cui
Keyword(s):  
Stem Cells ◽  
Nervous System ◽  
Cell Survival ◽  
Cancer Cells ◽  
Prion Protein ◽  
Therapeutic Target ◽  
Cancer Biology ◽  
Cellular Prion Protein ◽  
Potential Therapeutic Target

Prion protein has two isoforms including cellular prion protein (PrPC) and scrapie prion protein (PrPSc). PrPSc is the pathological aggregated form of prion protein and it plays an important role in neurodegenerative diseases. PrPC is a glycosylphosphatidylinositol (GPI)-anchored protein that can attach to a membrane. Its expression begins at embryogenesis and reaches the highest level in adulthood. PrPC is expressed in the neurons of the nervous system as well as other peripheral organs. Studies in recent years have disclosed the involvement of PrPC in various aspects of cancer biology. In this review, we provide an overview of the current understanding of the roles of PrPC in proliferation, cell survival, invasion/metastasis, and stem cells of cancer cells, as well as its role as a potential therapeutic target.

scholarly journals The role of cellular prion protein in lipid metabolism in the liver

Prion ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 95-108
Author(s):  
Amandeep Singh Arora ◽  
Saima Zafar ◽  
Umair Latif ◽  
Franc Llorens ◽  
Sabine Mihm ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Prion Protein ◽  
Cellular Prion Protein

scholarly journals Physiological role of prion protein in copper homeostasis and angiogenic mechanisms of endothelial cells

2019 ◽  
Vol 305 ◽  
pp. S26
Author(s):  
F. Rizzo ◽  
L. De Riccardis ◽  
V. Garzarelli ◽  
C. Intini ◽  
M. Greco ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Prion Protein ◽  
Physiological Role ◽  
Copper Homeostasis

724 The Functional Role of Cellular Prion Protein in the Enteric Nervous System

2010 ◽  
Vol 138 (5) ◽  
pp. S-97
Author(s):  
Gary R. Martin ◽  
Mohammad Bashashati ◽  
Catherine M. Keenan ◽  
Wallace K. MacNaughton ◽  
Frank Jirik ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Prion Protein ◽  
Functional Role ◽  
Cellular Prion Protein

scholarly journals The Role of the Octarepeat Region in Neuroprotective Function of the Cellular Prion Protein

2007 ◽  
Vol 17 (2) ◽  
pp. 174-183 ◽  
Author(s):  
Gerda Mitteregger ◽  
Milan Vosko ◽  
Bjarne Krebs ◽  
Wei Xiang ◽  
Veronika Kohlmannsperger ◽  
...  
Keyword(s):  
Prion Protein ◽  
Cellular Prion Protein ◽  
Neuroprotective Function

scholarly journals PrPSc in Salivary Glands of Scrapie-Affected Sheep

2007 ◽  
Vol 81 (9) ◽  
pp. 4872-4876 ◽  
Author(s):  
Marta Vascellari ◽  
Romolo Nonno ◽  
Franco Mutinelli ◽  
Michela Bigolaro ◽  
Michele Angelo Di Bari ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Prion Protein ◽  
Western Blotting ◽  
Horizontal Transmission ◽  
Infected Sheep ◽  
Healthy Controls

ABSTRACT The salivary glands of scrapie-affected sheep and healthy controls were investigated for the presence of the pathological prion protein (PrPSc). PrPSc was detected in major (parotid and mandibular) and minor (buccal, labial, and palatine) salivary glands of naturally and experimentally infected sheep. Using Western blotting, the PrPSc concentration in glands was estimated to be 0.02 to 0.005% of that in brain. Immunohistochemistry revealed intracellular depositions of PrPSc in ductal and acinar epithelia and occasional labeling in the lumina of salivary ducts. The presence of PrPSc in salivary glands highlights the possible role of saliva in the horizontal transmission of scrapie.

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