Essential Thrombocytosis and Hepatocellular Carcinoma: A Mechanistic Challenge

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S106-S106
Author(s):  
S Mohammed
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Concentration ◽  
Large Mass ◽  
Essential Thrombocytosis ◽  
Ethanol Abuse ◽  
History Of ◽  
Right Lobe ◽  
Alpha Feto Protein ◽  
Second Wave

Abstract Introduction/Objective Thrombocytosis has been reported in 8.2% of patients with Hepatocellular carcinoma [HCC] and has been attributed to increased Thrombopoietin [TPO] production by the tumor. Methods/Case Report We present a case of a 68-year-old male with a history of Hepatitis C and ethanol abuse presented with complaints of headache and chills. Imaging studies revealed a large mass in the liver [right lobe] suggesting an HCC of fibrolamellar type. His platelet count [PC] was 965 K/mcL. The serum AFP [Alpha feto protein] concentration was >51,800 ng/ml. There was no evidence of metastatic disease and the patient was started on Capecitabine and radiation therapy targeting the liver mass. Lung metastasis became evident and Sorafenib was added. His PCs and AFP concentrations however continued decreasing to 306 K/mcL and 460.7 ng/ml respectively. His PC then increased to a peak of 1.32 million/mcL 10 months later. The molecular workup done at our reference lab was positive for CALR [Calreticulin] mutation. The patient was started on Hydroxyurea and his PC decreased to 323 K/mcL at the time of writing. His AFP has remained stable. This case illuminates the complicated relationship between HCC and thrombocytosis. The therapy directed against the HCC did decrease PC and AFP concentration in our case. The second wave of thrombocytosis led to the discovery of CALR mutation, and the patient was diagnosed with Essential Thrombocytosis [ET]. Treatment with Hydroxyurea again decreased the PC while AFP concentration was increased but stable. Thrombopoietin levels have remained stable for the patient after treatment with Hydroxyurea. Results (if a Case Study enter NA) NA Conclusion Although the question of which mechanism(or possibly both) was at work in this case cannot be resolved definitely, two points are worth noting. The first is that- the assumption that the thrombocytosis was related to the HCC delayed testing for mutations associated with Essential Thrombocytosis. The second is that the TPO assay that may have yielded useful information in sorting out the alternatives was not ordered early enough before starting hydroxyurea.

Patient with Liver Failure Presenting for Transjugular Intrahepatic Portosystemic Shunt

2018 ◽  
pp. 215-222
Author(s):  
Marina Moguilevitch
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transjugular Intrahepatic Portosystemic Shunt ◽  
Portosystemic Shunt ◽  
Intractable Ascites ◽  
Technical Advances ◽  
Intrahepatic Portosystemic Shunt ◽  
History Of ◽  
Complications Of Cirrhosis

This chapter presents a case study of a 66-year-old man with a history of hepatitis C and cirrhosis complicated by intractable ascites who presents for an elective transjugular intrahepatic portosystemic shunt (TIPS) procedure. TIPS remains an important tool for the management of the complications of portal hypertension. Technical advances and clinical studies provide the evidence to define the best indications for the procedure. Patients who were successfully treated by TIPS still need regular follow up with a hepatologist. These patients remain at risk for development of other complications of cirrhosis such as hepatocellular carcinoma. This chapter discusses these issues and other concepts related to anesthetics for a liver transplant patient presenting for TIPS.

Press Propaganda and Subaltern Agents of Pan-Islamic Networks in the Muslim Mediterranean World prior to World War I

2018 ◽  
Author(s):  
Odile Moreau
Keyword(s):  
Middle East ◽  
World War I ◽  
North Africa ◽  
World War ◽  
Subaltern Studies ◽  
Resistance Movements ◽  
The Press ◽  
Mediterranean World ◽  
History Of

This chapter explores movement and circulation across the Mediterranean and seeks to contribute to a history of proto-nationalism in the Maghrib and the Middle East at a particular moment prior to World War I. The discussion is particularly concerned with the interface of two Mediterranean spaces: the Middle East (Egypt, Ottoman Empire) and North Africa (Morocco), where the latter is viewed as a case study where resistance movements sought external allies as a way of compensating for their internal weakness. Applying methods developed by Subaltern Studies, and linking macro-historical approaches, namely of a translocal movement in the Muslim Mediterranean, it explores how the Egypt-based society, al-Ittihad al-Maghribi, through its agent, Aref Taher, used the press as an instrument for political propaganda, promoting its Pan-Islamic programme and its goal of uniting North Africa.

Turning Aliens into Socialists

2010 ◽  
Vol 1 (1) ◽  
pp. 75-93
Author(s):  
Jessica Moberg
Keyword(s):  
Outer Space ◽  
The United States ◽  
Second World War ◽  
World War ◽  
History Of ◽  
Swedish History ◽  
Second World ◽  
The Universe ◽  
Highly Evolved

Immediately after the Second World War Sweden was struck by a wave of sightings of strange flying objects. In some cases these mass sightings resulted in panic, particularly after authorities failed to identify them. Decades later, these phenomena were interpreted by two members of the Swedish UFO movement, Erland Sandqvist and Gösta Rehn, as alien spaceships, or UFOs. Rehn argued that ‘[t]here is nothing so dramatic in the Swedish history of UFOs as this invasion of alien fly-things’ (Rehn 1969: 50). In this article the interpretation of such sightings proposed by these authors, namely that we are visited by extraterrestrials from outer space, is approached from the perspective of myth theory. According to this mythical theme, not only are we are not alone in the universe, but also the history of humankind has been shaped by encounters with more highly-evolved alien beings. In their modern day form, these kinds of ideas about aliens and UFOs originated in the United States. The reasoning of Sandqvist and Rehn exemplifies the localization process that took place as members of the Swedish UFO movement began to produce their own narratives about aliens and UFOs. The question I will address is: in what ways do these stories change in new contexts? Texts produced by the Swedish UFO movement are analyzed as a case study of this process.

A Case Study on the Process of Creating Interests in History of History-Deokhu

2019 ◽  
Vol 58 (1) ◽  
pp. 147-159
Author(s):  
Young-Seok Seo ◽  
Bong-Seok Kim
Keyword(s):  
History Of

Scales and Units

2018 ◽  
Author(s):  
Kathryn M. de Luna
Keyword(s):  
Language Change ◽  
Historical Linguistics ◽  
Bantu Languages ◽  
The North ◽  
First Case ◽  
Linguistic Evidence ◽  
River Region ◽  
History Of ◽  
Alternative Approaches

This chapter uses two case studies to explore how historians study language movement and change through comparative historical linguistics. The first case study stands as a short chapter in the larger history of the expansion of Bantu languages across eastern, central, and southern Africa. It focuses on the expansion of proto-Kafue, ca. 950–1250, from a linguistic homeland in the middle Kafue River region to lands beyond the Lukanga swamps to the north and the Zambezi River to the south. This expansion was made possible by a dramatic reconfiguration of ties of kinship. The second case study explores linguistic evidence for ridicule along the Lozi-Botatwe frontier in the mid- to late 19th century. Significantly, the units and scales of language movement and change in precolonial periods rendered visible through comparative historical linguistics bring to our attention alternative approaches to language change and movement in contemporary Africa.

Case Study: Rome's House of Memory and History: The Politics of Memory and Public Institutions

2012 ◽  
Author(s):  
Alessandro Portelli
Keyword(s):  
Oral History ◽  
Cultural Policy ◽  
Public Institutions ◽  
Politics Of Memory ◽  
Political Events ◽  
History Of ◽  
Ambitious Program ◽  
The City

This article centers around the case study of Rome's House of Memory and History to understand the politics of memory and public institutions. This case study is about the organization and politics of public memory: the House of Memory and History, established by the city of Rome in 2006, in the framework of an ambitious program of cultural policy. It summarizes the history of the House's conception and founding, describes its activities and the role of oral history in them, and discusses some of the problems it faces. The idea of a House of Memory and History grew in this cultural and political context. This article traces several political events that led to the culmination of the politics of memory and its effect on public institutions. It says that the House of Memory and History can be considered a success. A discussion on a cultural future winds up this article.

The Wolf Man’s Glückshaube: Rereading Sergei Pankejeff’s Memoir

2019 ◽  
Vol 67 (5) ◽  
pp. 789-814
Author(s):  
Anat Tzur Mahalel
Keyword(s):  
Complex Matrix ◽  
Neurotic Symptom ◽  
History Of ◽  
The Veil ◽  
Wolf Man

A comparative reading of Freud’s canonical case study “From the History of an Infantile Neurosis” (1918) and the memoir written by the protagonist of that study, Sergei Pankejeff, known as the Wolf Man (1971a), centers on the complex matrix of meanings embodied in the act of lifting the veil. The neurotic symptom of a veil seemingly in front of the analysand’s eyes is interpreted by Freud as a repetition of his birth in a Glückshaube (German for “caul,” literally a “lucky hood”). The veil is represented as an ambivalent object both for Freud and for Pankejeff, who are enticed by the sense of a final truth behind the veil yet constantly doubt the possibility of grasping it. For Freud, psychoanalysis is the very process of lifting the veil, yet his analysand remained for him an unsolved riddle. Pankejeff, in a volume dedicated to his identity as the Wolf Man (Gardiner 1971a), created an autobiographical text that deliberately avoids telling the story of the analysand, thus drawing a veil over his story. The paradox embodied in lifting the veil is discussed in relation to Walter Benjamin’s distinction between materiality and truth and his notion of the inherent unity of the veil and the veiled (1925).

Progressive Law, Activism, and Lawyering in an Age of Preemption

2021 ◽  
Vol 46 (1) ◽  
pp. 252-267
Author(s):  
Rashmi Dyal-Chand
Keyword(s):  
Working Conditions ◽  
Local Level ◽  
Global Supply Chain ◽  
Environmental Movements ◽  
Improve Working ◽  
Detailed History ◽  
History Of ◽  
State And Local ◽  
Core Questions

Preemption is one of the most important legal doctrines for today’s progressives to understand because of its power to constrain progressive policymaking and social movement lawyering at the state and local level. By examining the detailed history of a decades-long campaign by the labor and environmental movements to improve working conditions in an industry at the heart of the global supply chain, Scott L. Cummings’s Blue and Green: The Drive for Justice at America’s Port (2018) provides a case study about the doctrine and impacts of preemption. The study also inspires lawyers and activists alike to reexamine core questions of factual relevance, representation and voice, and precedent.

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