scholarly journals The role of endothelial filtration for locoregional targeting of hepatic tumours with endothelium-specific antibodies and nanoparticles

2018 ◽  
Vol 29 ◽  
pp. v5
Author(s):  
N. Winkler ◽  
F. Strübing ◽  
D. Kyuno ◽  
B. Qian ◽  
Z. Wang ◽  
...  
Keyword(s):  
Specific Antibodies ◽  
Hepatic Tumours

Mixed cryoglobulinemia: the role of HCV and organ-specific antibodies

1996 ◽  
pp. 283-293
Author(s):  
S. Bombardieri ◽  
A. Tavoni ◽  
M. Mosca ◽  
L. La Civita ◽  
M. P. Dolcher ◽  
...  
Keyword(s):  
Mixed Cryoglobulinemia ◽  
Specific Antibodies ◽  
Organ Specific

scholarly journals PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle

1989 ◽  
Vol 9 (9) ◽  
pp. 3710-3719
Author(s):  
J Banroques ◽  
J N Abelson
Keyword(s):  
Essential Role ◽  
Mrna Splicing ◽  
Ribonucleoprotein Particle ◽  
Specific Antibodies ◽  
Small Nuclear Ribonucleoprotein ◽  
Assembly Pathway ◽  
Nuclear Ribonucleoprotein ◽  
Small Nuclear Ribonucleoprotein Particle

The Saccharomyces cerevisiae prp mutants (prp2 through prp11) are known to be defective in pre-mRNA splicing at nonpermissive temperatures. We have sequenced the PRP4 gene and shown that it encodes a 52-kilodalton protein. We obtained PRP4 protein-specific antibodies and found that they inhibited in vitro pre-mRNA splicing, which confirms the essential role of PRP4 in splicing. Moreover, we found that PRP4 is required early in the spliceosome assembly pathway. Immunoprecipitation experiments with anti-PRP4 antibodies were used to demonstrate that PRP4 is a protein of the U4/U6 small nuclear ribonucleoprotein particle (snRNP). Furthermore, the U5 snRNP could be immunoprecipitated through snRNP-snRNP interactions in the large U4/U5/U6 complex.

Examination of the role of Mycoplasma bovis in bovine pneumonia and a mathematical model for its evaluation

2004 ◽  
Vol 52 (4) ◽  
pp. 445-456 ◽  
Author(s):  
M. Tenk ◽  
L. Stipkovits ◽  
L. Hufnagel
Keyword(s):  
Mathematical Model ◽  
Probability Model ◽  
Mycoplasma Bovis ◽  
Seropositivity Rate ◽  
Lung Lesions ◽  
Specific Antibodies ◽  
Cattle Herds ◽  
The Relationship

The authors screened 34 large cattle herds for the presence of Mycoplasma bovis infection by examining slaughtered cattle for macroscopic lung lesions, by culturing M. bovis from lung lesions and at the same time by testing sera for the presence of antibodies against M. bovis. Among the 595 cattle examined, 33.9% had pneumonic lesions, mycoplasmas were isolated from 59.9% of pneumonic lung samples, and 10.9% of sera from those animals contained antibodiesto M. bovis. In 25.2% of the cases M. bovis was isolated from lungs with no macroscopic lesions. The proportion of seropositive herds was 64.7%. The average seropositivity rate of individuals was 11.3% but in certain herds it exceeded 50%. A probability model was developed for examining the relationship among the occurrence of pneumonia, the isolation of M. bovis from the lungs and the presence of M. bovis specific antibodies in sera.

scholarly journals Antibodies Induced by Lipoarabinomannan in Bovines: Characterization and Effects on the Interaction betweenMycobacterium aviumSubsp.paratuberculosisand MacrophagesIn Vitro

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Ana Jolly ◽  
Silvia Beatriz Colavecchia ◽  
Bárbara Fernández ◽  
Eloy Fernández ◽  
Silvia Leonor Mundo
Keyword(s):  
Immune Response ◽  
Mycobacterium Avium ◽  
Active Role ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Specific Antibodies ◽  
Humoral Immune ◽  
Bovine Macrophage

Lipoarabinomannan (LAM) is a major glycolipidic antigen on the mycobacterial envelope. The aim of this study was to characterize the humoral immune response induced by immunization with a LAM extract in bovines and to evaluate the role of the generated antibodies in thein vitroinfection of macrophages withMycobacterium aviumsubsp.paratuberculosis(MAP). Sera from fourteen calves immunized with LAM extract or PBS emulsified in Freund's Incomplete Adjuvant and from five paratuberculosis-infected bovines were studied. LAM-immunized calves developed specific antibodies with IgG1 as the predominant isotype. Serum immunoglobulins were isolated and their effect was examined in MAP ingestion and viability assays using a bovine macrophage cell line. Our results show that the antibodies generated by LAM immunization significantly increase MAP ingestion and reduce its intracellular viability, suggesting an active role in this model.

scholarly journals Critical role of CD4 T cells in PF4/heparin antibody production in mice

Blood ◽  
2015 ◽  
Vol 125 (11) ◽  
pp. 1826-1829 ◽  
Author(s):  
Yongwei Zheng ◽  
Mei Yu ◽  
Anand Padmanabhan ◽  
Richard H. Aster ◽  
Liudi Yuan ◽  
...  
Keyword(s):  
T Cells ◽  
Antibody Production ◽  
Cd4 T Cells ◽  
Critical Role ◽  
Specific Antibodies ◽  
Key Points

Key Points CD4 T cells play a critical role in controlling production of PF4/heparin-specific antibodies.

scholarly journals Correlation between IL-36α and IL-17 and Activity of the Disease in Selected Autoimmune Blistering Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Agnieszka Żebrowska ◽  
Anna Woźniacka ◽  
Katarzyna Juczyńska ◽  
Kamila Ociepa ◽  
Elżbieta Waszczykowska ◽  
...  
Keyword(s):  
Dermatitis Herpetiformis ◽  
Tissue Injury ◽  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Control Group ◽  
Specific Antibodies ◽  
Relevant Role ◽  
Skin Conditions ◽  
Autoimmune Blistering Diseases

Dermatitis herpetiformis (DH), bullous pemphigoid (BP), and pemphigus vulgaris (PV) are autoimmune bullous skin conditions with eosinophilic and neutrophilic infiltrations. While cytokines are crucial for the affinity and activation of different leukocyte cells in the inflammation and blister formation, there are no studies concerning a role of IL-36. The goal of the study was to analyze whether interleukin 36 is involved in pathogenesis of DH, BP, and PV. And the second aim of the study was the estimation of correlation between IL-36 and IL-17 and titers of specific antibodies in these diseases. Expression of IL-36 and IL-17 was detected in serum in all DH, BP, and PV samples. Serum levels of IL-36 and IL-17α were statistically higher in DH, BP, and PV groups as compared to the control group. IL-36α levels were statistically higher in DH patients, as compared to patients with PV and BP. Our results showed that IL-36 may be helpful in the diagnostic and monitoring of the activity of the disease. IL-36 may play a relevant role of enrolling eosinophils and neutrophils in DH, BP, and PV and finally provoke tissue injury.

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