scholarly journals Aspiration Before Tissue Filler – An Exercise in Futility and Unsafe Practice

2021 ◽  
Author(s):  
Greg J Goodman ◽  
Mark D Magnusson ◽  
Peter Callan ◽  
Stefania Roberts ◽  
Sarah Hart ◽  
...  
Keyword(s):  
Bolus Injection ◽  
Intravascular Volume ◽  
Intravascular Injection ◽  
Pertinent Literature ◽  
Safety Measures ◽  
Pressure Injection ◽  
Filler Injections ◽  
Injection Techniques ◽  
Injection Location ◽  
Safety Advantage

Abstract Background Aesthetic physicians rely upon certain anecdotal beliefs regarding the safe practice of filler injections. These include a presumed safety advantage of bolus injection after a negative aspiration. Objectives The article aims to review and summarize the published literature on inadvertent intravascular injection of hyaluronic acid and to investigate whether the technique of aspiration confers any safety to the practitioner and the patient. Methods Pertinent literature was analyzed and our understanding of the safety of negative and positive aspiration outlined. Results The available studies demonstrate that aspiration cannot be relied upon and should not be used as a safety measure. It is safer to adopt injection techniques that will avoid injecting an intravascular volume with embolic potential than use an unreliable test to permit a risky injection. Conclusions To prevent intravascular injection, understanding “injection anatomy” and injection plane and techniques such as slow, low-pressure injection are important safety measures. Assurance of safety when delivering a bolus after negative aspiration, does not appear to be borne out by the available literature. If there is any doubt about the sensitivity or reliability of a negative aspiration, then there is no role for its use. Achieving a positive aspiration would just defer the risk to the next injection location where a negative aspiration would then be relied upon.

scholarly journals HA Filler Injection and Skin Quality–Literature Minireview and Injection Techniques

2020 ◽  
Vol 53 (02) ◽  
pp. 198-206
Author(s):  
Jui-Hui Peng ◽  
Peter Hsien-Li Peng
Keyword(s):  
Volume Loss ◽  
Quality Change ◽  
Facial Aging ◽  
Filler Injection ◽  
Quality Literature ◽  
The Face ◽  
Filler Injections ◽  
Injection Techniques ◽  
Injection Protocol ◽  
Skin Quality

AbstractAging of the face produces many changes in the structure and integrity of the skin and other anatomical aspects, the three major signs of which are volume loss, sagginess, and skin quality change. Through surgical or nonsurgical procedures, it is possible to slow or even reverse these mechanisms through artificial means, including thread lifting, radiofrequency, or filler injection. Filler injections are particularly popular in recent years, owing to their convenience, efficacy, and long-lasting results. In this minireview, the author outlines the basic mechanisms behind facial aging, discusses current literature on each aspect of facial aging, and offers injection protocol recommendations based on past literature and clinical experience.

scholarly journals Alopecia Induced by Autologous Fat Injection into the Temporal Area: Case Report and Review of the Literature

2019 ◽  
Vol 11 (2) ◽  
pp. 150-156 ◽  
Author(s):  
Saranya Khunkhet ◽  
Teerapong Rattananukrom ◽  
Wilai Thanasarnaksorn ◽  
Poonkiat Suchonwanit
Keyword(s):  
Fat Grafting ◽  
Intravascular Injection ◽  
Autologous Fat Grafting ◽  
External Compression ◽  
Temporal Area ◽  
Autologous Fat ◽  
First Case ◽  
Facial Filler ◽  
Vascular Compromise ◽  
Filler Injections

Alopecia secondary to facial filler injections is a highly unusual sequela. Only 2 cases of hyaluronic acid-induced alopecia have been reported to date. Accumulating evidence suggests vascular compromise as its etiology, which can be accidental intravascular injection or external compression by overfilled materials. We hereby present, to the best of our knowledge, the first case of localized nonscarring and scarring alopecia secondary to autologous fat grafting and review the literature regarding filler-induced alopecia.

Retro or PeriBulbar Injection Techniques to Reverse Visual Loss After Filler Injections

2015 ◽  
Vol 41 ◽  
pp. S354-S357 ◽  
Author(s):  
Jean Carruthers ◽  
Steven Fagien ◽  
Peter Dolman
Keyword(s):  
Visual Loss ◽  
Filler Injections ◽  
Injection Techniques

scholarly journals Evaluation of different contrast medium injection techniques in the Angio-CT study of the lower limbs in patients with obliterating arteriopathy

2021 ◽  
Author(s):  
Di Basilio Francesco ◽  
Canitano Stefano ◽  
Micheli Cinzia ◽  
Bifarini Roberta ◽  
Aguzzi Gilberto ◽  
...  
Keyword(s):  
Contrast Medium ◽  
Study Protocol ◽  
Bolus Injection ◽  
Lower Limbs ◽  
Injection Technique ◽  
Accurate Evaluation ◽  
Injection Techniques ◽  
Contrast Medium Injection ◽  
Angio Ct ◽  
Vital Parameters

The need to write this article was born with the aim of optimizing the Angio-CT study protocol of the lower limbs, comparing two Mdc injection techniques: standard and split bolus, performing a parameter check vital collected before and during injection of the Mdc in order to establish the plateau between reaching the peak of enhancement during the smartprep and the start of the scan. Then well defined parameters are assigned for the evaluation of the images obtained with the different techniques. In the study the inclusion or exclusion parameters of the patient are defined, recruiting 133 cases. The Split Bolus injection technique is optimal together with an accurate evaluation of the patient's vital parameters. Although appreciating the excellent results, the limits of this study are also described.

Permeability of Endometrial Blood Vessels to Exogenous Horse Radish Peroxidase in Mice. Electron Microscope Study

1973 ◽  
Vol 31 ◽  
pp. 562-563
Author(s):  
M.C. Castillo-Jessen ◽  
A. González-Angulo
Keyword(s):  
Electron Microscopy ◽  
Blood Vessels ◽  
Electron Microscope Study ◽  
Ultrastructural Level ◽  
Low Molecular Weight ◽  
Horse Radish Peroxidase ◽  
Intravascular Injection ◽  
Normal Morphology ◽  
Functional Implications ◽  
Low Molecular Weight Proteins

Information regarding the normal morphology of uterine blood vessels at ultrastructural level in mammals is scarce Electron microscopy studies dealing with endometrial vasculature despite the functional implications due to hormone priming are not available. Light microscopy observations with combined injection of dyes and microradiography along with histochemical studies does not enable us to know the detailed fine structure of the possible various types of blood vessels in this tissue. The present work has been designed to characterize the blood vessels of endometrium of mice as well as the behavior of the endothelium to injection of low molecular weight proteins during the normal estrous cycle in this animal. One hundred and forty female albino mice were sacrificed after intravascular injection of horse radish peroxidase (HRP) at 30 seconds, 5, 15, 30 and 60 minutes.

Pathophysiological function of the mitochondria as a calcium reservoir: Quantitative x-ray microanalysis

1990 ◽  
Vol 48 (2) ◽  
pp. 164-165
Author(s):  
K. Teraoka ◽  
N. Kaneko ◽  
Y. Horikawa ◽  
T. Uchida ◽  
R. Matsuda ◽  
...  
Keyword(s):  
Bolus Injection ◽  
Contact Method ◽  
X Ray

The aim of this study was to elucidate the role of the mitochondria as a store of calcium(Ca) under the condition of pathophysiological Ca overload induced by a rise in extracellular Ca concentration and the administration of isoproterenol.Eight rats were employed, and hearts were perfused as in the Langendorff method with Krebs-Henseleit solution gassed with 95% O2 and 5% CO2. Tow specimens were perfused with 2mM Ca for 30 min, and 2 were perfused with 5.5 mM Ca for 20 min. 4 specimens were perfused with 2 mM Ca for 5 min, and of these 4, 2 were infused with 10-7 mM/kg/min. isoproterenol for 5 min, and 2 were given a bolus injection of 3 x 10-7 mM isoproterenol. After rapid-cryofixation by the metal-mirror contact method with a Reichert-Jung KF80/MM80, and cryosectioning at -160 to -180° C with a Reichert-Jung Ultracut Fc-4E, ultrathin specimens (100nm) were free-ze-dreid for several hours at 10-5 Torr in the JEOL FD 7000, and mitochondrial Ca was determined by quantitative x-ray micranalysis (JEOL 1200EX, LINK AN 10000S).

Oxygen radicals participate in alloxan-induced pulmonary EDEMA

1990 ◽  
Vol 48 (3) ◽  
pp. 298-299
Author(s):  
Tomoo Kawada ◽  
Michio Arakawa ◽  
Kenjiro Kambara ◽  
Takashi Segawa ◽  
Fumio Ando ◽  
...  
Keyword(s):  
Pulmonary Edema ◽  
Oxygen Radicals ◽  
Bolus Injection ◽  
Physiological Saline ◽  
Baseline Period ◽  
Alveolar Epithelial Cells ◽  
Control Group ◽  
Intervention Period ◽  
Lung Water ◽  
Electron Microscopic

We know that alloxan causes increased-permeability pulmonary edema and that alloxan generates oxygen radicals (H2O2, O2−, ·OH) in blood. Therefore, we hypothesize that alloxan-generated oxygen radicals damage pulmonary capillary endothelial cells, and, possibly, alveolar epithelial cells as well. We examined whether oxygen radical scavengers, such as catalase or dimethylsulfoxide (DMSO), protected against alloxaninduced pulmonary edema.Five dogs in each following group were anesthetized: control group: physiological saline (20ml/kg/h); alloxan group: physiological saline + alloxan (75mg/kg) bolus injection at the beginning of the experiment; catalase group: physiological saline + catalase (150,000u/kg) bolus injection before injection of alloxan; DMSO group: physiological saline + DMSO (0.4mg/kg) bolus injection before alloxan. All dogs had 30-min baseline period and 3-h intervention period. Hemodynamics and circulating substances were measured at the specific points of time. At the end of intervention period, the dogs were killed and had the lungs removed for electron microscopic study and lung water measurement with direct destructive method.

Clinical and Scintigraphic Findings in Radiation Myositis Complicating the Intraperitoneal Administration of 198Au

1965 ◽  
Vol 05 (02) ◽  
pp. 188-196
Author(s):  
J. Němec ◽  
J. Kubalt ◽  
S. Vohnout ◽  
J. Schubert ◽  
J. Sudek ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Ascitic Fluid ◽  
Saline Solution ◽  
Intraperitoneal Administration ◽  
Clinical Findings ◽  
Safety Measures ◽  
Muscle Necrosis

SummaryPraeperitoneal administration of colloidal 198Au complicating the treatment of anascitic ovarian cancer is reported. Typical scintiscans and various clinical findings of muscle necrosis and radiation myositis are described. Administration of larger amount of saline solution preceding the radiogold instillation controlled by simultaneous scintiscanning are suggested as safety measures in patients when no ascitic fluid is present.

Demonstration and Quantitation of Pharmacological Inhibition of Pulmonary Uptake of N-lsopropyl-123l-p-lodoamphetamine by Propranolol

1989 ◽  
Vol 28 (03) ◽  
pp. 100-104 ◽  
Author(s):  
S. F. Akber
Keyword(s):  
Binding Sites ◽  
Bolus Injection ◽  
Cell Function ◽  
Lung Pathology ◽  
Lung Uptake ◽  
Pharmacological Inhibition ◽  
Sensitive Index ◽  
Pulmonary Uptake ◽  
First Pass

The first-pass pulmonary extraction values of N-lsopropyl-123l-p-lodoamphetamine (123I-IMP) in pretreated dogs decreases from 90 to 62% as the amount of propranolol increases from 0 to 20 mg. The first-pass pulmonary extraction values of 123I-IMP in dogs with a simultaneous bolus injection of propranolol decreases from 90 to 62% as the amount of propranolol increases from 0 to 10 mg. The pulmonary extraction of 123I-IMP with a simultaneous bolus injection of ketamine and 123I-IMP decreases from 90 to 64% as the ketamine dose increases from 0 to 100 mg. These results suggest that the pulmonary uptake of 123I-IMP may be at least partially mediated by receptors. They also indicate that endothelial metabolic cell function may be a useful index of early lung pathology. Furthermore, studies of the degree of lung uptake may be a sensitive index of pathologic states in which alterations of amine binding sites have occurred.

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