scholarly journals PSExplorer: whole parameter space exploration for molecular signaling pathway dynamics

2010 ◽  
Vol 26 (19) ◽  
pp. 2477-2479
Author(s):  
T. Q. Tung ◽  
D. Lee
Keyword(s):  
Signaling Pathway ◽  
Parameter Space ◽  
Space Exploration ◽  
Molecular Signaling ◽  
Molecular Signaling Pathway

scholarly journals New Tricks for an Old (Hedge)Hog: Sonic Hedgehog Regulation of Astrocyte Function

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1353
Author(s):  
A. Denise R. Garcia
Keyword(s):  
Signaling Pathway ◽  
Sonic Hedgehog ◽  
Synapse Formation ◽  
Inflammatory Responses ◽  
Molecular Signaling ◽  
Synaptic Organization ◽  
Shh Signaling ◽  
Broad Array ◽  
And Function ◽  
Molecular Signaling Pathway

The Sonic hedgehog (Shh) molecular signaling pathway is well established as a key regulator of neurodevelopment. It regulates diverse cellular behaviors, and its functions vary with respect to cell type, region, and developmental stage, reflecting the incredible pleiotropy of this molecular signaling pathway. Although it is best understood for its roles in development, Shh signaling persists into adulthood and is emerging as an important regulator of astrocyte function. Astrocytes play central roles in a broad array of nervous system functions, including synapse formation and function as well as coordination and orchestration of CNS inflammatory responses in pathological states. Neurons are the source of Shh in the adult, suggesting that Shh signaling mediates neuron–astrocyte communication, a novel role for this multifaceted pathway. Multiple roles for Shh signaling in astrocytes are increasingly being identified, including regulation of astrocyte identity, modulation of synaptic organization, and limitation of inflammation. This review discusses these novel roles for Shh signaling in regulating diverse astrocyte functions in the healthy brain and in pathology.

scholarly journals Raman observation of a molecular signaling pathway of apoptotic cells induced by photothermal therapy

2019 ◽  
Vol 10 (47) ◽  
pp. 10900-10910 ◽  
Author(s):  
Yingfang Xing ◽  
Zhewei Cai ◽  
Meijuan Xu ◽  
Wenzheng Ju ◽  
Xiaojun Luo ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Signaling Pathway ◽  
Photothermal Therapy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Apoptotic Cells ◽  
Molecular Signaling ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Molecular Signaling Pathway

A molecular signaling pathway of apoptosis induced by photothermal therapy was revealed by surface-enhanced Raman spectroscopy.

Molecular Signaling Pathway Governing GPR15 Expression

2017 ◽  
Vol 152 (5) ◽  
pp. S615
Author(s):  
Bryce Liao ◽  
Linh Nguyen ◽  
Aida Habtezion
Keyword(s):  
Signaling Pathway ◽  
Molecular Signaling ◽  
Molecular Signaling Pathway

ROS related enzyme levels and its association to molecular signaling pathway in the development of head and neck cancer

2018 ◽  
Vol 64 (7) ◽  
pp. 24
Author(s):  
Elif Sinem Iplik ◽  
Baris Ertugrul ◽  
Gonca Candan ◽  
Saim Pamuk ◽  
Levent Aydemir ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Signaling Pathway ◽  
Neck Cancer ◽  
Molecular Signaling ◽  
Related Enzyme ◽  
Molecular Signaling Pathway

scholarly journals Gene expression of components of the insulin/insulin-like signaling pathway in response to heat stress in the garter snake, Thamnophis elegans

2014 ◽  
Vol 121 (1-4) ◽  
pp. 1-4 ◽  
Author(s):  
Tonia S. Schwartz ◽  
Anne M. Bronikowski
Keyword(s):  
Gene Expression ◽  
Heat Stress ◽  
Signaling Pathway ◽  
External Stress ◽  
Garter Snake ◽  
Laboratory Model ◽  
Molecular Signaling ◽  
Thamnophis Elegans ◽  
Molecular Signaling Pathway ◽  
Normal Laboratory

The insulin/insulin-like signaling (IIS) pathway is an evolutionary conserved molecular signaling pathway that regulates growth, reproduction, stress resistance, and longevity in response to nutrition and external stress. While the constituents of this pathway and their functions are relatively well understood in laboratory model animals, they have not been explored in many other organisms, with notable exceptions in the fisheries literature. We tested for the gene expression of four key components of this pathway in the garter snake (Thamnophis elegans) liver, and determine how the transcription of these components responds to heat stress. We found that the two insulin-like growth factor ligands (IGF-1 and IGF-2) and the receptors (IGF-1 Receptor and M6P/IGF-2 Receptor, or IGF-1R and IGF-2R) are expressed in garter snake liver tissue. Under normal laboratory conditions, IGF-2 and IGF-2R are expressed at a higher level than IGF-1 and IGF-1R. In response to heat stress, IGF-1 expression remained the same, IGF-2 expression decreased, and the expression of both receptors increased. These results demonstrate that elements of the IIS pathway are responsive to heat stress in snakes. Further studies are needed to fully understand the biological consequences of this response.

Rapid Characterization and Parameter Space Exploration of Perovskites Using an Automated Routine

2019 ◽  
Vol 22 (1) ◽  
pp. 6-17 ◽  
Author(s):  
Elisabeth Reinhardt ◽  
Ahmed M. Salaheldin ◽  
Monica Distaso ◽  
Doris Segets ◽  
Wolfgang Peukert
Keyword(s):  
Parameter Space ◽  
Space Exploration ◽  
Rapid Characterization

scholarly journals Parameter space exploration of the minimal SU(5) unification

2021 ◽  
Vol 104 (1) ◽  
Author(s):  
Ilja Doršner ◽  
Emina Džaferović-Mašić ◽  
Shaikh Saad
Keyword(s):  
Parameter Space ◽  
Space Exploration
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