scholarly journals 427 The Effect of Malnutrition on Early Outcomes after Cancer Surgery: An International Prospective Cohort Study in 82 Countries

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
A Riad ◽  
S Knight ◽  
E Harrison
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Elective Surgery ◽  
Final Analysis ◽  
Cancer Surgery ◽  
Postoperative Outcomes ◽  
Disease Stage ◽  
Severe Malnutrition ◽  
Colorectal Cancer Surgery ◽  
After Cancer

Abstract Background Malnutrition is a state linked to worse postoperative outcomes, and cancer patients are particularly vulnerable due to cachexia. We aimed to explore the effect of malnutrition on 30-day mortality following gastric and colorectal cancer surgery. Method GlobalSurg3 was multicentre international cohort study which collected data from consecutive patients undergoing emergency or elective surgery for gastric and colorectal cancer. Malnutrition was defined using the Global Leadership Initiative on Malnutrition (GLIM) criteria. Multilevel variable regression approaches determined the relationship between malnutrition and early postoperative outcomes. Results 6438 patients were included in the final analysis (1184 gastric cancer; 5254 colorectal cancer). Severe malnutrition was common across all income-strata, affecting 1 in 4 patients overall, with a higher burden in low and lower-middle income countries (64%). In patients undergoing elective surgery (n = 5709), severe malnutrition was independently associated with increased mortality (aOR = 1.62 (1.07-2.48, P = 0.024) after accounting for patient factors, disease stage and country effects. Conclusions Severe malnutrition represents a high global burden in cancer surgery, particularly within lower income settings. Malnutrition is an independent risk-factor for 30-day mortality following elective surgery for gastric and colorectal cancer, suggesting perioperative nutritional interventions may improve outcomes after cancer surgery.

scholarly journals O19 The effect of malnutrition on early outcomes after elective cancer surgery: an international prospective cohort study in 82 countries

2021 ◽  
Vol 108 (Supplement_5) ◽  
Author(s):  
Aya M Riad ◽  
Stephen R Knight ◽  
M Ewen ◽  
Keyword(s):  
Gastric Cancer ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Elective Surgery ◽  
Cancer Surgery ◽  
Postoperative Outcomes ◽  
Severe Malnutrition ◽  
Middle Income ◽  
Middle Income Countries

Abstract Introduction Malnutrition is a key priority on the global health agenda, yet the impact of nutritional state on cancer surgery across income strata remains poorly described. This study aimed to determine the effect of malnutrition on early postoperative outcomes following elective surgery for colorectal or gastric cancer. Method Multicentre, international prospective cohort study of consecutive patients undergoing elective surgery for colorectal or gastric cancer. Malnutrition was defined using the Global Leadership Initiative on Malnutrition (GLIM) criteria. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression and three-way mediation analysis determined the relationship between country income group, nutritional status and early postoperative outcomes. Result This study included 5709 patients (4593 colorectal; 1116 gastric) from 381 hospitals in 75 countries. Severe malnutrition was present in one third of patients, with a disproportionate burden in upper middle (44%) and low/lower-middle income countries (64%). After adjustment for patient and hospital risk factors, severe malnutrition (aOR 1.62, 95% confidence interval 1.07 to 2.48; P = 0.024) was an independent predictor of 30-day mortality. However, major postoperative complications and surgical site infection rates were similar. Conclusion Severe malnutrition represents a high global burden in cancer surgery, particularly within low-income settings. Malnutrition is an independent risk-factor for 30-day mortality following elective surgery for colorectal or gastric cancer, suggesting perioperative nutritional interventions may improve early outcomes following cancer surgery. Take-home Message Severe malnutrition affects a large proportion of elective surgical oncology patients, with a significantly higher burden in low and middle income countries. Severe malnutrition is independently associated with increased 30-day mortality after cancer surgery.

scholarly journals Early Inflammatory Biomarkers as Predictive Factors for Freedom from Infection after Colorectal Cancer Surgery: A Prospective Cohort Study

2018 ◽  
Vol 19 (4) ◽  
pp. 446-450 ◽  
Author(s):  
André Goulart ◽  
Carla Ferreira ◽  
Alexandra Estrada ◽  
Fernanda Nogueira ◽  
Sandra Martins ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Predictive Factors ◽  
Prospective Cohort ◽  
Cancer Surgery ◽  
Inflammatory Biomarkers ◽  
Colorectal Cancer Surgery

A multicentre comparison of a fast track or conventional postoperative protocol following laparoscopic or open elective surgery for colorectal cancer surgery

2014 ◽  
Vol 16 (2) ◽  
pp. 134-140 ◽  
Author(s):  
F. Esteban ◽  
F. J. Cerdan ◽  
M. Garcia-Alonso ◽  
R. Sanz-Lopez ◽  
A. Arroyo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fast Track ◽  
Elective Surgery ◽  
Cancer Surgery ◽  
Colorectal Cancer Surgery

scholarly journals Preliminary Results of an Exercise Program After Laparoscopic Resective Colorectal Cancer Surgery in Non-Metastatic Adenocarcinoma: A Pilot Study of a Randomized Control Trial

Medicina ◽  
2020 ◽  
Vol 56 (2) ◽  
pp. 78
Author(s):  
Gabriele Mascherini ◽  
Maria Novella Ringressi ◽  
Jorge Castizo-Olier ◽  
Georgian Badicu ◽  
Alfredo Irurtia ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fat Mass ◽  
Elective Surgery ◽  
Cell Mass ◽  
Exercise Program ◽  
Cancer Surgery ◽  
Lower Limbs ◽  
Control Group ◽  
Colorectal Cancer Surgery ◽  
Preliminary Results

Background and objectives: Performing physical exercise after a colorectal cancer diagnosis is associated with lower mortality related to the tumor itself. In order to improve physical recovery after elective surgery, there are no specific exercise protocols after discharge from the hospital. The purpose of this study is to show the preliminary results of an exercise program after colorectal cancer surgery. Materials and Methods: Six patients with non-metastatic colorectal adenocarcinoma addressed to respective laparoscopic were randomly assigned to a mixed supervised/home-based exercise program for six months and compared to a control group without exercise. To assess the effectiveness of the program, functional and body composition parameters were evaluated. Results: Three months after surgery, the exercise group increased flexibility (p <0.01, ES = 0.33), strength of lower limbs (p <0.01, ES = 0.42) and aerobic capacity (p <0.01, ES = 0.28). After surgery, the six patients experienced a significant reduction in body mass index (BMI) and free fat mass. More specifically, fat mass reached the lowest values, with a concomitant increase in cell mass after six months (p <0.01, ES = 0.33). This did not occur in the control group. Conclusions: Colorectal cancer treatment induces a reduction in physical function, particularly during the first six months after treatment. A mixed exercise approach appears promising in countering this process after colorectal cancer surgery.

scholarly journals Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study

2018 ◽  
Vol 27 (10) ◽  
pp. 2427-2435 ◽  
Author(s):  
Amanda Cummings ◽  
Chloe Grimmett ◽  
Lynn Calman ◽  
Mubarak Patel ◽  
Natalia Vadimovna Permyakova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cohort Study ◽  
Well Being ◽  
Cancer Surgery ◽  
Colorectal Cancer Surgery

scholarly journals Liver disease and 30-day mortality after colorectal cancer surgery: a Danish population-based cohort study

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Jonathan Montomoli ◽  
Rune Erichsen ◽  
Christian Fynbo Christiansen ◽  
Sinna Pilgaard Ulrichsen ◽  
Lars Pedersen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Liver Disease ◽  
Population Based ◽  
Cancer Surgery ◽  
Danish Population ◽  
Colorectal Cancer Surgery
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