scholarly journals 739 Pancreatic Cancer and Bariatric Surgery: Narrative Review

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
H Al-Saadi ◽  
H Malallah ◽  
T Al-Saadi
Keyword(s):  
Bariatric Surgery ◽  
Pancreatic Cancer ◽  
Weight Reduction ◽  
Narrative Review ◽  
Ductal Adenocarcinoma ◽  
Increase Cancer Risk ◽  
Epidemiological Evidence ◽  
Cochrane Database ◽  
Post Bariatric Surgery ◽  
Dose Dependent

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer with an estimated incidence of 8 per 100,000 person-years and mortality of 7 per 100,000 person-years worldwide. Method A narrative review of the literature was conducted. PubMed, Web of Science and Cochrane database were searched for all published papers in Pancreatic cancer post Bariatric surgery from 1990 to November 2020. Results Epidemiological evidence in the literature has shown that obesity as a risk factor for the development of PDAC is a dose dependent risk. The review found that the risk of developing pancreatic cancer in obese or overweight individuals is 1.5 times higher than individuals with a normal BMI. At the same time, evidence from literature demonstrated that weight reduction by dietary restriction, physical activities, pharmacotherapy or weight reduction surgery reduces risk of PDAC.A total of 24 cases of pancreatic cancer were identified in the literature reported post Bariatric Surgery. The average age at diagnosis was 57.2 years and onset from surgery to diagnosis ranged from 2 months to 25 years. Of the identified cases, 23 cases were post Roux-en-Y Gastric Bypass and one case post Duodenal Switch. The review found that PDAC was the commonest reported pancreatic cancer post bariatric surgery accounting for 85.3%, followed by Neuroendocrine Tumours (NET) 16.7%. Given the variation in onset of diagnosis, bariatric surgery did not increase cancer risk but rather accelerated the diagnosis of pancreatic cancer. Conclusions Along with weight reduction and improving comorbidities, Bariatric surgery reduces risk of obesity-related carcinogenesis.

scholarly journals Obesity and Biliopancreatic Cancers: Exploring Current Evidence

2021 ◽  
Vol 07 (09) ◽  
Author(s):  
Hatem Al-Saadi ◽  
Keyword(s):  
Bariatric Surgery ◽  
Pancreatic Cancer ◽  
Weight Reduction ◽  
Current Evidence ◽  
Medical Subject Headings ◽  
Manual Search ◽  
Mesh Terms ◽  
Post Bariatric Surgery ◽  
The Relationship ◽  
Dose Dependent

Background: Pancreatic cancer (PC) is among foremost causes of cancer related deaths worldwide due to generic symptoms and lack of screening. The risk of developing pancreatic cancer in obese or overweight individuals is 1.5 times higher than individuals with a normal BMI. Bariatric Surgery has been associated with a reduction of obesity- related cancer, however, the number of cases that developed pancreatic cancer post Bariatric surgery is not known. Aim: Examine the relationship between Bariatric Surgery and Pancreatic cancer and identify reported cases of pancreatic cancer after bariatric surgery. Materials and Methods: A narrative review of the literature was conducted. A MEDLINE database search was performed using the following Medical Subject Headings (MeSH) terms: pancreatic cancer, bariatric surgery, weight reduction surgery, pancreatic adenocarcinoma. These were combined with the following: postoperative, after surgery, and during surgery. A WebScience search was then performed using similar terms. Additional references were then identified by manual search of the articles obtained from the MEDLINE and Web of Science. Cancer cases that were identified at the pre-operative period or intra-operatively were excluded. The searches covered the period from January 2000 to November 2020. Results/Review: Epidemiological evidence has shown that obesity as a risk factor for the development of PC is a dose dependent risk. The review found that the risk of developing pancreatic cancer in obese or overweight individuals is 1.5 times higher than individuals with a normal BMI. At the same time, evidence from literature demonstrated that weight reduction by dietary restriction, physical activities, pharmacotherapy or weight reduction surgery reduces risk of PDAC. A total of 24 cases of pancreatic cancer were identified and reported post Bariatric Surgery in the literature. The average age at diagnosis was 57.2 years and onset from surgery to diagnosis ranged from 2 months to 25 years. Of the identified cases, 23 cases were post Roux-en-Y Gastric Bypass and one case post Duodenal Switch. The review found that PDAC was the commonest reported pancreatic cancer post bariatric surgery accounting for 58.3%, followed by Neuroendocrine Tumours (NET) 16.7%. Conclusions: Along with weight reduction and improving comorbidities, Bariatric surgery reduces risk of obesity-related carcinogenesis. Given the variation in onset of diagnosis, bariatric surgery did not increase cancer risk but rather accelerated the diagnosis of pancreatic cancer.

Changes in headache frequency in premenopausal obese women with migraine after bariatric surgery: A case series

Cephalalgia ◽  
2011 ◽  
Vol 31 (13) ◽  
pp. 1336-1342 ◽  
Author(s):  
V Novack ◽  
L Fuchs ◽  
L Lantsberg ◽  
S Kama ◽  
U Lahoud ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Reduction ◽  
Case Series ◽  
Control Group ◽  
Obese Women ◽  
Specific Effects ◽  
Migraine Frequency ◽  
Reduced Frequency ◽  
Causal Nature ◽  
Post Bariatric Surgery

Background: The association between migraine and obesity gives the clinician with an exciting possibility to alleviate migraine suffering through weight-reduction gastric-restrictive operations. We hypothesized that bariatric weight-reduction intervention (gastric banding) will be associated with reduction of migraine burden in this population. Methods: A total of 105 women between 18 and 50 years of age, admitted for bariatric surgery between April 2006 and February 2007, were screened for migraine. Twenty-nine with diagnosis of migraine were enrolled into the prospective phase. We followed the migraine pattern of these patients for 6 months post bariatric surgery. Results: Baseline median migraine frequency was six headache days a month. Post bariatric surgery, the migraine-suffering women reported of a lower frequency of migraine attacks ( p < 0.001), shorter duration of the attacks ( p = 0.02), lower medication use during the attack ( p = 0.005), less non-migraine pain (44.8 vs. 33%, p = 0.05), and post-bariatric surgery reduction in headache-related disability assessed by the MIDAS and HIT-6 scores. There was a reduction in migraine frequency among both episodic (from four to one episodes a month) and chronic (from 16.8 to 8.5 episodes per month) migraine patient cohorts separately and combined. Conclusions: Among migraine-suffering premenopausal obese women, we found a reduced frequency of migraine attacks and improvement of headache-related disability post bariatric surgery. Our findings should be interpreted cautiously. The absence of a control group and the non-blinded nature of our small study make it difficult to draw firm conclusions about the causal nature of the headache changes observed in this population. Further study is needed to evaluate the possible specific effects of surgical weight loss on migraine in obese women.

Liraglutide treatment in post-bariatric surgery patients who failed to maintain weight reduction

2017 ◽  
Vol 13 (10) ◽  
pp. S144 ◽  
Author(s):  
Naim shehadeh ◽  
Wisam Abo Zaid ◽  
Nehama Zuckerman Levin ◽  
Wasim Said ◽  
Sagit Zolotov ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Reduction ◽  
Post Bariatric Surgery

scholarly journals Chylous Ascites, Unusual Association with Ductal Pancreatic Adenocarcinoma with Plasmacytoid Morphology: A Case Report and Literature Review

2021 ◽  
Vol 07 (03) ◽  
pp. e158-e162
Author(s):  
Catalin Bogdan Satala ◽  
Ioan Jung ◽  
Tivadar Jr. Bara ◽  
Vlad Tudorache ◽  
Simona Gurzu
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Cells ◽  
Surgical Intervention ◽  
Chylous Ascites ◽  
Distal Portion ◽  
Ductal Adenocarcinoma ◽  
Lymph Vessels ◽  
Lymphangiosis Carcinomatosa ◽  
Ductal Pancreatic Adenocarcinoma ◽  
Tumor Emboli

AbstractChylous ascites represents a relatively uncommon condition. In this paper, we present a case of chyloperitoneum associated with pancreatic ductal adenocarcinoma (PDAC) and a review of literature regarding chylous ascites. A 76-year-old male patient was admitted in emergency department with acute abdomen. A pancreatic cancer was suspected. Subtotal spleno-pancreatectomy, for a nodular mass infiltrating the mild and distal portion of the pancreas, was necessary. During surgical intervention in the peritoneal cavity, a moderate quantity of whitish and thick consistency fluid with milk-like appearance was observed to be accumulated. After examination of the fluid, chyloperitoneum was diagnosed. The histologic examination showed a PDAC, with multiple emboli in lymph vessels, with tumor cells with plasmacytoid morphology, diagnosed as lymphangiosis carcinomatosa. The patient died at 3 weeks after surgical intervention. In patients with pancreatic cancer and chylous ascites, suspicion of tumor-related blockage of the lymphatic flow should be suspected. Prognosis of PDAC should be evaluated not only based on the number of lymph node metastases, but also considering the number of lymph vessels with tumor emboli and the architecture of tumor cells. This is the first reported case of a PDAC with plasmacytoid morphology of lymphangiosis carcinomatosa.

Sign in / Sign up

Export Citation Format

Share Document