scholarly journals Obesity and Biliopancreatic Cancers: Exploring Current Evidence

2021 ◽  
Vol 07 (09) ◽  
Author(s):  
Hatem Al-Saadi ◽  
Keyword(s):  
Bariatric Surgery ◽  
Pancreatic Cancer ◽  
Weight Reduction ◽  
Current Evidence ◽  
Medical Subject Headings ◽  
Manual Search ◽  
Mesh Terms ◽  
Post Bariatric Surgery ◽  
The Relationship ◽  
Dose Dependent

Background: Pancreatic cancer (PC) is among foremost causes of cancer related deaths worldwide due to generic symptoms and lack of screening. The risk of developing pancreatic cancer in obese or overweight individuals is 1.5 times higher than individuals with a normal BMI. Bariatric Surgery has been associated with a reduction of obesity- related cancer, however, the number of cases that developed pancreatic cancer post Bariatric surgery is not known. Aim: Examine the relationship between Bariatric Surgery and Pancreatic cancer and identify reported cases of pancreatic cancer after bariatric surgery. Materials and Methods: A narrative review of the literature was conducted. A MEDLINE database search was performed using the following Medical Subject Headings (MeSH) terms: pancreatic cancer, bariatric surgery, weight reduction surgery, pancreatic adenocarcinoma. These were combined with the following: postoperative, after surgery, and during surgery. A WebScience search was then performed using similar terms. Additional references were then identified by manual search of the articles obtained from the MEDLINE and Web of Science. Cancer cases that were identified at the pre-operative period or intra-operatively were excluded. The searches covered the period from January 2000 to November 2020. Results/Review: Epidemiological evidence has shown that obesity as a risk factor for the development of PC is a dose dependent risk. The review found that the risk of developing pancreatic cancer in obese or overweight individuals is 1.5 times higher than individuals with a normal BMI. At the same time, evidence from literature demonstrated that weight reduction by dietary restriction, physical activities, pharmacotherapy or weight reduction surgery reduces risk of PDAC. A total of 24 cases of pancreatic cancer were identified and reported post Bariatric Surgery in the literature. The average age at diagnosis was 57.2 years and onset from surgery to diagnosis ranged from 2 months to 25 years. Of the identified cases, 23 cases were post Roux-en-Y Gastric Bypass and one case post Duodenal Switch. The review found that PDAC was the commonest reported pancreatic cancer post bariatric surgery accounting for 58.3%, followed by Neuroendocrine Tumours (NET) 16.7%. Conclusions: Along with weight reduction and improving comorbidities, Bariatric surgery reduces risk of obesity-related carcinogenesis. Given the variation in onset of diagnosis, bariatric surgery did not increase cancer risk but rather accelerated the diagnosis of pancreatic cancer.

scholarly journals 739 Pancreatic Cancer and Bariatric Surgery: Narrative Review

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
H Al-Saadi ◽  
H Malallah ◽  
T Al-Saadi
Keyword(s):  
Bariatric Surgery ◽  
Pancreatic Cancer ◽  
Weight Reduction ◽  
Narrative Review ◽  
Ductal Adenocarcinoma ◽  
Increase Cancer Risk ◽  
Epidemiological Evidence ◽  
Cochrane Database ◽  
Post Bariatric Surgery ◽  
Dose Dependent

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer with an estimated incidence of 8 per 100,000 person-years and mortality of 7 per 100,000 person-years worldwide. Method A narrative review of the literature was conducted. PubMed, Web of Science and Cochrane database were searched for all published papers in Pancreatic cancer post Bariatric surgery from 1990 to November 2020. Results Epidemiological evidence in the literature has shown that obesity as a risk factor for the development of PDAC is a dose dependent risk. The review found that the risk of developing pancreatic cancer in obese or overweight individuals is 1.5 times higher than individuals with a normal BMI. At the same time, evidence from literature demonstrated that weight reduction by dietary restriction, physical activities, pharmacotherapy or weight reduction surgery reduces risk of PDAC.A total of 24 cases of pancreatic cancer were identified in the literature reported post Bariatric Surgery. The average age at diagnosis was 57.2 years and onset from surgery to diagnosis ranged from 2 months to 25 years. Of the identified cases, 23 cases were post Roux-en-Y Gastric Bypass and one case post Duodenal Switch. The review found that PDAC was the commonest reported pancreatic cancer post bariatric surgery accounting for 85.3%, followed by Neuroendocrine Tumours (NET) 16.7%. Given the variation in onset of diagnosis, bariatric surgery did not increase cancer risk but rather accelerated the diagnosis of pancreatic cancer. Conclusions Along with weight reduction and improving comorbidities, Bariatric surgery reduces risk of obesity-related carcinogenesis.

Changes in headache frequency in premenopausal obese women with migraine after bariatric surgery: A case series

Cephalalgia ◽  
2011 ◽  
Vol 31 (13) ◽  
pp. 1336-1342 ◽  
Author(s):  
V Novack ◽  
L Fuchs ◽  
L Lantsberg ◽  
S Kama ◽  
U Lahoud ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Reduction ◽  
Case Series ◽  
Control Group ◽  
Obese Women ◽  
Specific Effects ◽  
Migraine Frequency ◽  
Reduced Frequency ◽  
Causal Nature ◽  
Post Bariatric Surgery

Background: The association between migraine and obesity gives the clinician with an exciting possibility to alleviate migraine suffering through weight-reduction gastric-restrictive operations. We hypothesized that bariatric weight-reduction intervention (gastric banding) will be associated with reduction of migraine burden in this population. Methods: A total of 105 women between 18 and 50 years of age, admitted for bariatric surgery between April 2006 and February 2007, were screened for migraine. Twenty-nine with diagnosis of migraine were enrolled into the prospective phase. We followed the migraine pattern of these patients for 6 months post bariatric surgery. Results: Baseline median migraine frequency was six headache days a month. Post bariatric surgery, the migraine-suffering women reported of a lower frequency of migraine attacks ( p < 0.001), shorter duration of the attacks ( p = 0.02), lower medication use during the attack ( p = 0.005), less non-migraine pain (44.8 vs. 33%, p = 0.05), and post-bariatric surgery reduction in headache-related disability assessed by the MIDAS and HIT-6 scores. There was a reduction in migraine frequency among both episodic (from four to one episodes a month) and chronic (from 16.8 to 8.5 episodes per month) migraine patient cohorts separately and combined. Conclusions: Among migraine-suffering premenopausal obese women, we found a reduced frequency of migraine attacks and improvement of headache-related disability post bariatric surgery. Our findings should be interpreted cautiously. The absence of a control group and the non-blinded nature of our small study make it difficult to draw firm conclusions about the causal nature of the headache changes observed in this population. Further study is needed to evaluate the possible specific effects of surgical weight loss on migraine in obese women.

Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis

2018 ◽  
Vol 105 (2) ◽  
pp. 225-228 ◽  
Author(s):  
Ujwal Kariholu ◽  
Paolo Montaldo ◽  
Theodora Markati ◽  
Peter J Lally ◽  
Russell Pryce ◽  
...  
Keyword(s):  
Usual Care ◽  
Therapeutic Hypothermia ◽  
Data Extraction ◽  
Meta Analysis ◽  
Adverse Outcomes ◽  
Whole Body ◽  
Current Evidence ◽  
Neonatal Encephalopathy ◽  
Medical Subject Headings ◽  
Manual Search

ObjectivesTo examine if therapeutic hypothermia reduces the composite outcome of death, moderate or severe disability at 18 months or more after mild neonatal encephalopathy (NE).Data sourceMEDLINE, Cochrane database, Scopus and ISI Web of Knowledge databases, using ‘hypoxic ischaemic encephalopathy’, ‘newborn’ and ‘hypothermia’, and ‘clinical trials’ as medical subject headings and terms. Manual search of the reference lists of all eligible articles and major review articles and additional data from the corresponding authors of selected articles.Study selectionRandomised and quasirandomised controlled trials comparing therapeutic hypothermia with usual care.Data extractionSafety and efficacy data extracted independently by two reviewers and analysed.ResultsWe included the data on 117 babies with mild NE inadvertently recruited to five cooling trials (two whole-body cooling and three selective head cooling) of moderate and severe NE, in the meta-analysis. Adverse outcomes occurred in 11/56 (19.6%) of the cooled babies and 12/61 (19.7%) of the usual care babies (risk ratio 1.11 (95% CIs 0.55 to 2.25)).ConclusionsCurrent evidence is insufficient to recommend routine therapeutic hypothermia for babies with mild encephalopathy and significant benefits or harm cannot be excluded.

scholarly journals Medical subject headings for the scientific groups evolution analysis on the example of academician A.I. Archakov's scientific school

2020 ◽  
Vol 66 (1) ◽  
pp. 7-17
Author(s):  
E.V. Ilgisonis ◽  
O.I. Kiseleva ◽  
A.V. Lisitsa ◽  
E.V. Poverennaya ◽  
M.N. Toporkova ◽  
...  
Keyword(s):  
Relative Frequency ◽  
Semantic Network ◽  
Scientific School ◽  
Frequency Of Occurrence ◽  
Medical Subject Headings ◽  
Evolution Analysis ◽  
Mesh Terms ◽  
Academic School ◽  
Key Terms ◽  
The Relationship

This paper proposes a method of comparative analysis of scientific trajectories based on bibliographic profiles. The bibliographic profile (“meshprint”) is a list of MeSH terms (key terms used to index articles in the PubMed), indicating the relative frequency of occurrence of each term in the scientist's articles. Comparison of personalized bibliographic profiles can be represented in the form of a semantic network, where the nodes are the names of scientists, and the relationships are proportional to the calculated measures of similarity of bibliographic profiles. The proposed method was used to analyze the semantic network of scientists united by the academic school of the academician A.I. Archakov. The results of the work allowed us to show the relationship between the scientific trajectories of one scientific school and to correlate the results with world trends.

Liraglutide treatment in post-bariatric surgery patients who failed to maintain weight reduction

2017 ◽  
Vol 13 (10) ◽  
pp. S144 ◽  
Author(s):  
Naim shehadeh ◽  
Wisam Abo Zaid ◽  
Nehama Zuckerman Levin ◽  
Wasim Said ◽  
Sagit Zolotov ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Reduction ◽  
Post Bariatric Surgery

Loeys–Dietz syndrome pathology and aspects of cardiovascular management: A systematic review

Vascular ◽  
2020 ◽  
pp. 170853812093458 ◽  
Author(s):  
Rizwan Iqbal ◽  
Samiha Alom ◽  
Jalal BinSaeid ◽  
Amer Harky
Keyword(s):  
Autosomal Dominant ◽  
Genetic Disorder ◽  
Aortic Aneurysms ◽  
Current Evidence ◽  
Medical Subject Headings ◽  
Genetic Studies ◽  
Mesh Terms ◽  
Life Threatening ◽  
History Of ◽  
Systemic Manifestations

Loeys–Dietz syndrome is an autosomal dominant genetic disorder which is associated with significant and often crucial vascular manifestations. This review is aimed to examine current evidence on pathophysiology and management of Loeys–Dietz syndrome in current era. A comprehensive electronic search was done to identify the articles that discussed all the aspects of Loeys–Dietz syndrome, combined key words and Medical Subject Headings (MeSH) terms were used. Relevant articles have been summarized in each relevant section. Loeys–Dietz syndrome is an autosomal dominant genetic disorder which has combined and multi-systemic manifestations. The increased breakdown of extracellular matrix predisposes an individual to developing aneurysms in the aortic tree which is undoubtedly the most significant complication of this disorder. Understanding the pathophysiology and natural history of Loeys–Dietz syndrome and regular surveillance is important to plan prophylactic interventions to prevent life-threatening aortic emergencies which can be fatal. Loeys–Dietz syndrome is an aggressive genetic condition that predisposes an individual to the development of life-threatening aortic aneurysms. Our understanding of Loeys–Dietz syndrome remains ever-changing and it is likely that the knowledge regarding its diagnosis and treatment will become more clearly defined in the coming years with deeper genetic studies.

Relationship Between Hormonal Mechanisms of Diabetes Mellitus and Hypothyroidism Post-Bariatric Surgery

2020 ◽  
Vol 16 (3) ◽  
pp. 200-203
Author(s):  
Lucas G. Goes ◽  
Camila da Luz Eltchechem ◽  
Jessica Wouk ◽  
Carlos R.M. Malfatti ◽  
Luiz A. da Silva
Keyword(s):  
Diabetes Mellitus ◽  
Bariatric Surgery ◽  
Thyroid Hormones ◽  
Literature Search ◽  
Pharmacological Action ◽  
Health Maintenance ◽  
Physiological Capacity ◽  
Beneficial Action ◽  
Post Bariatric Surgery ◽  
The Relationship

Background: Obesity, diabetes mellitus may be related to the health, the relationship and the physiological capacity of the production of thyroid hormones (TH), triiodothyronine (T3) and thyroxine (T4). Objectives: The main aims of this review are to describe the relationship between obesity, appetite, weight management, hormonal mechanisms of diabetes mellitus and hypothyroidism post-bariatric surgery. Methodology: An in-depth literature search was conducted to identify scientific studies, which analyzed the correlation between diabetes mellitus and hypothyroidism post-bariatric surgery. Results: Bariatric surgery decreases hypothyroidism, reduces the need for pharmacological action (such as levothyroxine), controls the weight and body fat and increases the sensitivity to leptin and insulin. Conclusion: The reduction of the stomach and intestine by bariatric surgery is an evolutionary and beneficial action, because it may lead to a drastic decrease on numbers of conditions such as diabetes, obesity, hypothyroidism, and others. Thus, new studies should also focus on patients’ post-operatory conditions, such as lifetime, regulation and functioning of organs after reduced nutrition, and consumption and delivery of nutrients to health maintenance.

scholarly journals Mapping the biomedical sciences using Medical Subject Headings: a comparison between MeSH co-assignments and MeSH citation pairs

2021 ◽  
Vol 109 (3) ◽  
Author(s):  
Fei Shu ◽  
Junping Qiu ◽  
Vincent Larivière
Keyword(s):  
Web Of Science ◽  
Mesh Term ◽  
Biomedical Science ◽  
Journal Articles ◽  
Biomedical Sciences ◽  
Medical Subject Headings ◽  
Mesh Terms ◽  
Subject Headings ◽  
Direct Citation ◽  
The Relationship

Objective: This study compares two maps of biomedical sciences using Medical Subject Headings (MeSH) term co-assignments versus MeSH terms of citing/cited articles and reveals similarities and differences between the two approaches. Methods: MeSH terms assigned to 397,475 journal articles published in 2015, as well as their 4,632,992 cited references, were retrieved from Web of Science and MEDLINE databases, respectively, which formed over 7 million MeSH co-assignments and nearly 18 million direct citation pairs. We generated six network visualizations of biomedical science at three levels using Gephi software based on these MeSH co-assignments and citation pairs.Results: The MeSH co-assignment map contained more nodes and edges, as MeSH co-assignments cover all medical topics discussed in articles. By contrast, the MeSH citation map contained fewer but larger nodes and wider edges, as citation links indicate connections to two similar medical topics. Conclusion: These two types of maps emphasize different aspects of biomedical sciences, with MeSH co-assignment maps focusing on the relationship between topics in different categories and MeSH direct citation maps providing insights into relationships between topics in the same or similar category.

scholarly journals Bariatric Surgery as Potential Treatment for Nonalcoholic Fatty Liver Disease: A Future Treatment by Choice or by Chance?

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Shuja Hafeez ◽  
Mohamed H. Ahmed
Keyword(s):  
Bariatric Surgery ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Weight Reduction ◽  
Fatty Liver Disease ◽  
Current Evidence ◽  
Future Research ◽  
Lifestyle Modifications ◽  
Nonalcoholic Fatty Liver

Morbid obesity is strongly associated with nonalcoholic fatty liver disease (NAFLD) which is one of the most common causes of chronic liver disease worldwide. The current best treatment of NAFLD and NASH is weight reduction through life style modifications, antiobesity medication, and bariatric surgery. Importantly, bariatric surgery is the best alternative option for weight reduction if lifestyle modifications and pharmacological therapy have not yielded long-term success. Bariatric surgery is an effective treatment option for individuals who are grossly obese and associated with marked decrease in obesity-related morbidity and mortality. The most common performed bariatric surgery is Roux-en-Y gastric bypass (RYGB). The current evidence suggests that bariatric surgery in these patients will decrease the grade of steatosis, hepatic inflammation, and fibrosis. NAFLDper seis not an indication for bariatric surgery. Further research is urgently needed to determine (i) the benefit of bariatric surgery in NAFLD patients at high risk of developing liver cirrhosis (ii) the role of bariatric surgery in modulation of complications of NAFLD like diabetes and cardiovascular disease. The outcomes of the future research will determine whether bariatric surgery will be one of the recommended choice for treatment of the most progressive type of NAFLD.

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