scholarly journals The influence of phytic acid in wheat bran on early biomarkers of colon carcinogenesis

1998 ◽  
Vol 19 (6) ◽  
pp. 1087-1092 ◽  
Author(s):  
M Jenab
2009 ◽  
Vol 37 (1) ◽  
pp. 621-627 ◽  
Author(s):  
Arvind Kumar ◽  
Nikhlesh Kumar Singh ◽  
Pushpalata Rabindra Sinha ◽  
Raj Kumar

2000 ◽  
Vol 21 (8) ◽  
pp. 1547-1552 ◽  
Author(s):  
Mazda Jenab ◽  
Lilian U. Thompson

2000 ◽  
Vol 84 (5) ◽  
pp. 635-643 ◽  
Author(s):  
Anne-Maria Pajari ◽  
Seija Oikarinen ◽  
Soile Gråsten ◽  
Marja Mutanen

The role of dietary fibres in colon carcinogenesis is controversial. To elucidate the mechanisms by which different dietary fibre sources may affect colonic tumour development, we studied the effects of diets enriched with cereal brans or inulin on protein kinase C (PKC) activity and isozyme expression in rat colon. Male Wistar rats (twelve per group) were fed one of the following AIN-93G-based diets () for 4 weeks: a non-fibre high-fat diet or one of the four high-fat diets supplemented with either rye, oat or wheat bran or inulin at 100 g/kg diet. The fat concentration (20 g/100 g) and fatty acid composition of the non-fibre high-fat diet was designed to approximate that in a typical Western-type diet. In the proximal colon, rats fed the inulin diet had a significantly higher membrane PKC activity and a higher membrane PKC δ level than rats fed the non-fibre diet (P<0·05). In the distal colon, rats fed the inulin and oat bran diets had a higher total PKC activity and a higher membrane PKC β2 level than rats fed the wheat-bran diet. Rats in the non-fibre and wheat-bran groups had the lowest concentrations of luminal diacylglycerol. In conclusion, feeding of wheat bran resulted in low distal PKC activity and expression of PKC β2, a PKC isozyme related to colonic cell proliferation and increased susceptibility for colon carcinogenesis, which may explain in part the protective effect of wheat bran against tumour development in a number of experimental colon cancer studies. The increase in PKC activity and PKC β2 expression by feeding inulin may be a drawback of inulin as a functional food.


1999 ◽  
Vol 141 (1-2) ◽  
pp. 139-146 ◽  
Author(s):  
Takuya Takahashi ◽  
Mikiko Satou ◽  
Nami Watanabe ◽  
Yukiko Sakaitani ◽  
Akimitsu Takagi ◽  
...  

2000 ◽  
Vol 130 (8) ◽  
pp. 2020-2025 ◽  
Author(s):  
Hubert W. Lopez ◽  
Franck Vallery ◽  
Marie-Anne Levrat-Verny ◽  
Charles Coudray ◽  
Christian Demigné ◽  
...  

2013 ◽  
Vol 9 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Mahsa Majzoobi ◽  
Safora Pashangeh ◽  
Asgar Farahnaky

AbstractTo increase the dietary fiber of sponge cake, it was enriched with wheat bran of different levels (0, 5, 10, 15, and 20%, w/w; flour basis) and particle sizes (90, 170, 280, and 420 μm). The results showed that both crude fiber and phytic acid contents of the bran decreased with the reduction in the particle size. Batter density increased whereas batter consistency decreased with increase in the particle size and the level of the bran. The crust and crumb color became darker, more reddish and less yellowish as the level and particle size of the bran increased. Density of the cakes decreased as higher percentages and coarser brans were included. Determination of the textural properties of the cakes using texture profile analysis technique showed that with increase in the percentage of wheat bran, hardness, gumminess, and chewiness increased whereas, cohesiveness and springiness decreased. According to the taste panel, using no more than 10% bran with particle size smaller than 170 μm resulted in cakes similar to the control. The total dietary fiber and phytic acid content of the resultant cakes was 5.95% and 2.90 (mg/g), respectively.


2012 ◽  
Vol 38 (3) ◽  
pp. 987-995 ◽  
Author(s):  
Mahsa Majzoobi ◽  
Safoora Pashangeh ◽  
Asgar Farahnaky

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