Objective:
This study aimed to detect hepatic oxidative damage caused by aflatoxin B1
(AFB1), as well as to examine how propolis protects against hepatotoxic effects of AFB1.
Method:
Rats were split into four groups as control group, AFB1 group, propolis group, AFB1+
propolis group.
Results:
There was significant increase in malondialdehyde (MDA) level and tumor suppressor protein
(TP53) gene expression, Glutathione (GSH) level, Catalase (CAT) activity, CAT gene expression
decreased in AFB1 group in blood. MDA level and Glutathione-S-Transferase (GST) activity, GST
and TP53 gene expressions increased in AFB1 group, whereas GSH level and CAT activity alongside
CAT gene expression decreased in liver. AFB1+propolis group showed significant decrease in MDA
level, GST activity, TP53 and GST gene expressions, GSH level and CAT activity and CAT gene
expression increased in liver compared to AFB1 group.
Conclusion:
These results suggest that propolis may potentially be natural agent that prevents AFB1-
induced oxidative stress and hepatotoxicity.
Potent protective effect of isoimperatorin against aflatoxin B1-inducible cytotoxicity in H4IIE cells: bifunctional effects on glutathione S-transferase and CYP1A
