scholarly journals Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B1 in human lung: differential cellular distribution and lack of significance of the GSTM1 genetic polymorphism

1999 ◽  
Vol 20 (10) ◽  
pp. 1971-1977 ◽  
Author(s):  
Richard K. Stewart ◽  
Graeme B.J. Smith ◽  
Patty J. Donnelly ◽  
Ken R. Reid ◽  
Dimitri Petsikas ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Aflatoxin B1 ◽  
Human Lung ◽  
Cellular Distribution ◽  
Glutathione S Transferase

Chemoprotective Effects of Propolis on Aflatoxin B1-Induced Hepatotoxicity in Rats: Oxidative Damage and Hepatotoxicity by Modulating TP53, Oxidative Stress

2020 ◽  
Vol 17 (3) ◽  
pp. 191-199
Author(s):  
Seval Yilmaz ◽  
Fatih Mehmet Kandemir ◽  
Emre Kaya ◽  
Mustafa Ozkaraca
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Oxidative Damage ◽  
Aflatoxin B1 ◽  
Tp53 Gene ◽  
Control Group ◽  
Glutathione S Transferase ◽  
Gene Expressions ◽  
Cat Gene ◽  
Gst Activity

Objective: This study aimed to detect hepatic oxidative damage caused by aflatoxin B1 (AFB1), as well as to examine how propolis protects against hepatotoxic effects of AFB1. Method: Rats were split into four groups as control group, AFB1 group, propolis group, AFB1+ propolis group. Results: There was significant increase in malondialdehyde (MDA) level and tumor suppressor protein (TP53) gene expression, Glutathione (GSH) level, Catalase (CAT) activity, CAT gene expression decreased in AFB1 group in blood. MDA level and Glutathione-S-Transferase (GST) activity, GST and TP53 gene expressions increased in AFB1 group, whereas GSH level and CAT activity alongside CAT gene expression decreased in liver. AFB1+propolis group showed significant decrease in MDA level, GST activity, TP53 and GST gene expressions, GSH level and CAT activity and CAT gene expression increased in liver compared to AFB1 group. Conclusion: These results suggest that propolis may potentially be natural agent that prevents AFB1- induced oxidative stress and hepatotoxicity.

scholarly journals Genetic polymorphism of epoxide hydrolase and glutathione S-transferase in COPD

2004 ◽  
Vol 23 (6) ◽  
pp. 818-824 ◽  
Author(s):  
S‐L. Cheng ◽  
C‐J. Yu ◽  
C‐J. Chen ◽  
P‐C. Yang
Keyword(s):  
Genetic Polymorphism ◽  
Epoxide Hydrolase ◽  
Glutathione S Transferase

scholarly journals Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma

1996 ◽  
Vol 17 (9) ◽  
pp. 1855-1859 ◽  
Author(s):  
Takahiko Katoh ◽  
Naoki Nagata ◽  
Yusuke Kuroda ◽  
Hideaki Itoh ◽  
Akio Kawahara ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Colorectal Adenocarcinoma ◽  
Glutathione S Transferase

Inhibition of microsome-mediated binding of aflatoxin B1 to DNA by glutathione S-transferase

1980 ◽  
Vol 9 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Prabhaker D. Lotlikar ◽  
Susan M. Insetta ◽  
Paula R. Lyons ◽  
Eun-Chung Jhee
Keyword(s):  
Aflatoxin B1 ◽  
Glutathione S Transferase

Changes in hepatic cytosolic glutathione S-transferase activity and expression of its class-P during prenatal and postnatal period in rats treated with aflatoxin B1

2006 ◽  
Vol 80 (9) ◽  
pp. 572-579 ◽  
Author(s):  
Faezeh Fatemi ◽  
Abdolamir Allameh ◽  
Abolfazl Dadkhah ◽  
Mehdi Forouzandeh ◽  
Somayeh Kazemnejad ◽  
...  
Keyword(s):  
Aflatoxin B1 ◽  
Postnatal Period ◽  
Transferase Activity ◽  
Glutathione S Transferase ◽  
Cytosolic Glutathione

Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: Mechanisms of inducible resistance to aflatoxin B1

1998 ◽  
Vol 111-112 ◽  
pp. 51-67 ◽  
Author(s):  
John D Hayes ◽  
David J Pulford ◽  
Elizabeth M Ellis ◽  
Ronald McLeod ◽  
Roger F.L James ◽  
...  
Keyword(s):  
Aflatoxin B1 ◽  
Glutathione S Transferase ◽  
Chemopreventive Agents ◽  
Inducible Resistance
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