scholarly journals Functional Organization for Response Inhibition in the Right Inferior Frontal Cortex of Individual Human Brains

2020 ◽  
Vol 30 (12) ◽  
pp. 6325-6335 ◽  
Author(s):  
Akimitsu Suda ◽  
Takahiro Osada ◽  
Akitoshi Ogawa ◽  
Masaki Tanaka ◽  
Koji Kamagata ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Functional Properties ◽  
Response Inhibition ◽  
Functional Organization ◽  
Inferior Frontal Gyrus ◽  
Inferior Frontal Cortex ◽  
Functional Features ◽  
The Right ◽  
Human Brains ◽  
Individual Human

Abstract The right inferior frontal cortex (IFC) is critical to response inhibition. The right IFC referred in the human studies of response inhibition is located in the posterior part of the inferior frontal gyrus and the surrounding regions and consists of multiple areas that implement distinct functions. Recent studies using resting-state functional connectivity have parcellated the cerebral cortex and revealed across-subject variability of parcel-based cerebrocortical networks. However, how the right IFC of individual brains is functionally organized and what functional properties the IFC parcels possess regarding response inhibition remain elusive. In the present functional magnetic resonance imaging study, precision functional mapping of individual human brains was adopted to the parcels in the right IFC to evaluate their functional properties related to response inhibition. The right IFC consisted of six modules or subsets of subregions, and the spatial organization of the modules varied considerably across subjects. Each module revealed unique characteristics of brain activity and its correlation to behavior related to response inhibition. These results provide updated functional features of the IFC and demonstrate the importance of individual-focused approaches in studying response inhibition in the right IFC.

scholarly journals Function and Structure of the Right Inferior Frontal Cortex Predict Individual Differences in Response Inhibition: A Model-Based Approach

2008 ◽  
Vol 28 (39) ◽  
pp. 9790-9796 ◽  
Author(s):  
B. U. Forstmann ◽  
S. Jahfari ◽  
H. S. Scholte ◽  
U. Wolfensteller ◽  
W. P. M. van den Wildenberg ◽  
...  
Keyword(s):  
Individual Differences ◽  
Frontal Cortex ◽  
Response Inhibition ◽  
Model Based ◽  
Inferior Frontal Cortex ◽  
The Right

The right inferior frontal cortex in response inhibition: A tDCS–ERP co-registration study

NeuroImage ◽  
2016 ◽  
Vol 140 ◽  
pp. 66-75 ◽  
Author(s):  
Toni Cunillera ◽  
Debora Brignani ◽  
David Cucurell ◽  
Lluís Fuentemilla ◽  
Carlo Miniussi
Keyword(s):  
Frontal Cortex ◽  
Response Inhibition ◽  
Inferior Frontal Cortex ◽  
The Right

scholarly journals Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach

2018 ◽  
Vol 33 (3) ◽  
pp. 335-346 ◽  
Author(s):  
A Correas ◽  
E López-Caneda ◽  
L Beaton ◽  
S Rodríguez Holguín ◽  
LM García-Moreno ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Frontal Cortex ◽  
Binge Drinking ◽  
Target Detection ◽  
Attentional Control ◽  
Theta Power ◽  
Inferior Frontal Cortex ◽  
Binge Drinkers ◽  
The Right ◽  
Integrative Processing

Background: The prevalence of binge drinking has risen in recent years. It is associated with a range of neurocognitive deficits among adolescents and young emerging adults who are especially vulnerable to alcohol use. Attention is an essential dimension of executive functioning and attentional disturbances may be associated with hazardous drinking. The aim of the study was to examine the oscillatory neural dynamics of attentional control during visual target detection in emerging young adults as a function of binge drinking. Method: In total, 51 first-year university students (18 ± 0.6 years) were assigned to light drinking ( n = 26), and binge drinking ( n = 25) groups based on their alcohol consumption patterns. A high-density magnetoencephalography signal was combined with structural magnetic resonance imaging in an anatomically constrained magnetoencephalography model to estimate event-related source power in a theta (4–7 Hz) frequency band. Phase-locked co-oscillations were further estimated between the principally activated regions during task performance. Results: Overall, the greatest event-related theta power was elicited by targets in the right inferior frontal cortex and it correlated with performance accuracy and selective attention scores. Binge drinkers exhibited lower theta power and dysregulated oscillatory synchrony to targets in the right inferior frontal cortex, which correlated with higher levels of alcohol consumption. Conclusions: These results confirm that a highly interactive network in the right inferior frontal cortex subserves attentional control, revealing the importance of theta oscillations and neural synchrony for attentional capture and contextual maintenance. Attenuation of theta power and synchronous interactions in binge drinkers may indicate early stages of suboptimal integrative processing in young, highly functioning binge drinkers.

scholarly journals Task-Dependent Modulation of Regions in the Left Inferior Frontal Cortex during Semantic Processing

2001 ◽  
Vol 13 (6) ◽  
pp. 829-843 ◽  
Author(s):  
A. L. Roskies ◽  
J. A. Fiez ◽  
D. A. Balota ◽  
M. E. Raichle ◽  
S. E. Petersen
Keyword(s):  
Frontal Cortex ◽  
Language Processing ◽  
Semantic Processing ◽  
Semantic Analysis ◽  
Lexical Processing ◽  
Temporal Cortex ◽  
Dependent Manner ◽  
Inferior Frontal Cortex ◽  
Semantic Judgment ◽  
The Right

To distinguish areas involved in the processing of word meaning (semantics) from other regions involved in lexical processing more generally, subjects were scanned with positron emission tomography (PET) while performing lexical tasks, three of which required varying degrees of semantic analysis and one that required phonological analysis. Three closely apposed regions in the left inferior frontal cortex and one in the right cerebellum were significantly active above baseline in the semantic tasks, but not in the nonsemantic task. The activity in two of the frontal regions was modulated by the difficulty of the semantic judgment. Other regions, including some in the left temporal cortex and the cerebellum, were active across all four language tasks. Thus, in addition to a number of regions known to be active during language processing, regions in the left inferior frontal cortex were specifically recruited during semantic processing in a task-dependent manner. A region in the right cerebellum may be functionally related to those in the left inferior frontal cortex. Discussion focuses on the implications of these results for current views regarding neural substrates of semantic processing.

Activation of Right Inferior Frontal Gyrus during Response Inhibition across Response Modalities

2007 ◽  
Vol 19 (1) ◽  
pp. 69-80 ◽  
Author(s):  
Junichi Chikazoe ◽  
Seiki Konishi ◽  
Tomoki Asari ◽  
Koji Jimura ◽  
Yasushi Miyashita
Keyword(s):  
Response Inhibition ◽  
Inferior Frontal Gyrus ◽  
Imaging Study ◽  
Task Structure ◽  
Antisaccade Task ◽  
Preparatory Set ◽  
Different Response ◽  
The Right ◽  
Meta Analyses ◽  
Modality Difference

The go/no-go task, which effectively taps the ability to inhibit prepotent response tendency, has consistently activated the lateral prefrontal cortex, particularly the right inferior frontal gyrus (rIFG). On the other hand, rIFG activation has rarely been reported in the antisaccade task, seemingly an oculomotor version of the manual go/no-go task. One possible explanation for the variable IFG activation is the modality difference of the two tasks: The go/no-go task is performed manually, whereas the antisaccade task is performed in the oculomotor modality. Another explanation is that these two tasks have different task structures that require different cognitive processes: The traditional antisaccade task requires (i) configuration of a preparatory set prior to antisaccade execution and (ii) response inhibition at the time of antisaccade execution, whereas the go/no-go task requires heightened response inhibition under a minimal preparatory set. To test these possibilities, the traditional antisaccade task was modified in the present functional magnetic resonance imaging study such that it required heightened response inhibition at the time of antisaccade execution under a minimal preparatory set. Prominent activation related to response inhibition was observed in multiple frontoparietal regions, including the rIFG. Moreover, meta-analyses revealed that the rIFG activation in the present study was observed in the go/no-go tasks but not in the traditional antisaccade task, indicating that the rIFG activation was sensitive to the task structure difference, but not to the response modality difference. These results suggest that the rIFG is part of a network active during response inhibition across different response modalities.

Effect of an electrical stimulation session on the right inferior frontal gyrus on the response inhibition

2019 ◽  
Vol 12 (2) ◽  
pp. 556
Author(s):  
A. Abdorahimi ◽  
A. Sohrabi
Keyword(s):  
Electrical Stimulation ◽  
Response Inhibition ◽  
Inferior Frontal Gyrus ◽  
The Right

scholarly journals Healthy women with severe early life trauma show altered neural facilitation of emotion inhibition under acute stress

2019 ◽  
Vol 50 (12) ◽  
pp. 2075-2084
Author(s):  
Sabrina Golde ◽  
Katja Wingenfeld ◽  
Antje Riepenhausen ◽  
Nina Schröter ◽  
Juliane Fleischer ◽  
...  
Keyword(s):  
Response Inhibition ◽  
Early Life ◽  
Acute Stress ◽  
Clinical Symptoms ◽  
Inferior Frontal Gyrus ◽  
History Of Or ◽  
Fearful Faces ◽  
Early Life Trauma ◽  
History Of ◽  
The Right

AbstractBackgroundAcross psychopathologies, trauma-exposed individuals suffer from difficulties in inhibiting emotions and regulating attention. In trauma-exposed individuals without psychopathology, only subtle alterations of neural activity involved in regulating emotions have been reported. It remains unclear how these neural systems react to demanding environments, when acute (non-traumatic but ordinary) stress serves to perturbate the system. Moreover, associations with subthreshold clinical symptoms are poorly understood.MethodsThe present fMRI study investigated response inhibition of emotional faces before and after psychosocial stress situations. Specifically, it compared 25 women (mean age 31.5 ± 9.7 years) who had suffered severe early life trauma but who did not have a history of or current psychiatric disorder, with 25 age- and education-matched trauma-naïve women.ResultsUnder stress, response inhibition related to fearful faces was reduced in both groups. Compared to controls, trauma-exposed women showed decreased left inferior frontal gyrus (IFG) activation under stress when inhibiting responses to fearful faces, while activation of the right anterior insula was slightly increased. Also, groups differed in brain–behaviour correlations. Whereas stress-induced false alarm rates on fearful stimuli negatively correlated with stress-induced IFG signal in controls, in trauma-exposed participants, they positively correlated with stress-induced insula activation.ConclusionNeural facilitation of emotion inhibition during stress appears to be altered in trauma-exposed women, even without a history of or current psychopathology. Decreased activation of the IFG in concert with heightened bottom-up salience of fear related cues may increase vulnerability to stress-related diseases.

Insula and Orbital Frontal Cortex Activity Underlying Emotion Interference Resolution in Working Memory

2010 ◽  
Vol 22 (12) ◽  
pp. 2790-2803 ◽  
Author(s):  
Sara M. Levens ◽  
Elizabeth A. Phelps
Keyword(s):  
Working Memory ◽  
Conflict Resolution ◽  
Frontal Cortex ◽  
Inferior Frontal Gyrus ◽  
Anterior Insula ◽  
Orbital Frontal Cortex ◽  
Emotional Information ◽  
Interference Resolution ◽  
Emotional Interference ◽  
The Right

Previous research has shown that emotional information aids conflict resolution in working memory [WM; Levens, S. M., & Phelps, E. A. Emotion processing effects on interference resolution in working memory. Journal of Emotion, 8, 267–280, 2008]. Using a recency-probes WM paradigm, it was found that positive and negative emotional stimuli reduced the amount of interference created when information that was once relevant conflicted with currently relevant information. To explore the neural mechanisms behind these facilitation effects, an event-related fMRI version of the recency-probes task was conducted using neutral and arousing positive and negative words as stimuli. Results replicate previous findings showing that the left and right inferior frontal gyrus (IFG) is involved in the interference resolution of neutral information and reveal that the IFG is involved in the interference resolution of emotional information as well. In addition, ROIs in the right and left anterior insula and in the right orbital frontal cortex (OFC) were identified that appear to underlie emotional interference resolution in WM. We conclude that the IFG underlies neutral and emotional interference resolution, and that additional regions of the anterior insula and OFC may contribute to the facilitation of interference resolution for emotional information. These findings clarify the role of the insula and OFC in affective and executive processing, specifically in WM conflict resolution.

scholarly journals Deficits in inferior frontal cortex activation in euthymic bipolar disorder patients during a response inhibition task

2012 ◽  
Vol 14 (4) ◽  
pp. 442-450 ◽  
Author(s):  
Jennifer D Townsend ◽  
Susan Y Bookheimer ◽  
Lara C Foland-Ross ◽  
Teena D Moody ◽  
Naomi I Eisenberger ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Frontal Cortex ◽  
Response Inhibition ◽  
Inferior Frontal Cortex
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