Deficits in inferior frontal cortex activation in euthymic bipolar disorder patients during a response inhibition task

This pre-registered experiment sought to uncover the temporal relationship between the inferior frontal cortex (IFC) and the pre-supplementary motor area (pre-SMA) during stopping of an ongoing action. Both regions have previously been highlighted as being central to cognitive control of actions, particularly response inhibition. Here we tested which area is activated first during the stopping process using magnetoencephalography, before assessing the relative chronometry of each region using functionally localized transcranial magnetic stimulation. Both lines of evidence pointed towards simultaneous activity across both regions, suggesting that parallel, mutually interdependent processing may form the cortical basis of stopping. Additional exploratory analysis, however, provided weak evidence in support of previous suggestions that the pre-SMA may provide an ongoing drive of activity to the IFC.

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Dissociable recruitment of rostral anterior cingulate and inferior frontal cortex in emotional response inhibition

NeuroImage ◽

10.1016/j.neuroimage.2008.04.248 ◽

2008 ◽

Vol 42 (2) ◽

pp. 988-997 ◽

Cited By ~ 71

Author(s):

Pearl H. Chiu ◽

Avram J. Holmes ◽

Diego A. Pizzagalli

Keyword(s):

Frontal Cortex ◽

Response Inhibition ◽

Emotional Response ◽

Anterior Cingulate ◽

Inferior Frontal Cortex

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Functional Organization for Response Inhibition in the Right Inferior Frontal Cortex of Individual Human Brains

Cerebral Cortex ◽

10.1093/cercor/bhaa188 ◽

2020 ◽

Vol 30 (12) ◽

pp. 6325-6335 ◽

Cited By ~ 1

Author(s):

Akimitsu Suda ◽

Takahiro Osada ◽

Akitoshi Ogawa ◽

Masaki Tanaka ◽

Koji Kamagata ◽

...

Keyword(s):

Frontal Cortex ◽

Functional Properties ◽

Response Inhibition ◽

Functional Organization ◽

Inferior Frontal Gyrus ◽

Inferior Frontal Cortex ◽

Functional Features ◽

The Right ◽

Human Brains ◽

Individual Human

Abstract The right inferior frontal cortex (IFC) is critical to response inhibition. The right IFC referred in the human studies of response inhibition is located in the posterior part of the inferior frontal gyrus and the surrounding regions and consists of multiple areas that implement distinct functions. Recent studies using resting-state functional connectivity have parcellated the cerebral cortex and revealed across-subject variability of parcel-based cerebrocortical networks. However, how the right IFC of individual brains is functionally organized and what functional properties the IFC parcels possess regarding response inhibition remain elusive. In the present functional magnetic resonance imaging study, precision functional mapping of individual human brains was adopted to the parcels in the right IFC to evaluate their functional properties related to response inhibition. The right IFC consisted of six modules or subsets of subregions, and the spatial organization of the modules varied considerably across subjects. Each module revealed unique characteristics of brain activity and its correlation to behavior related to response inhibition. These results provide updated functional features of the IFC and demonstrate the importance of individual-focused approaches in studying response inhibition in the right IFC.

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