A Recent Review of Secondary Mobile Phase Modifiers Used to Enhance the Chromatographic Analysis of Pharmaceuticals

1988 ◽  
Vol 26 (8) ◽  
pp. 388-400 ◽  
Author(s):  
R. K. Gilpin ◽  
S. S. Yang ◽  
G. Werner
Keyword(s):  
Chromatographic Analysis ◽  
Mobile Phase ◽  
Mobile Phase Modifiers

Determination of Cymiazole Residues in Honey by Liquid Chromatography

1993 ◽  
Vol 76 (1) ◽  
pp. 92-94 ◽  
Author(s):  
Paolo Cabras ◽  
Marinella Melis ◽  
Lorenzo Spanedda
Keyword(s):  
Liquid Chromatography ◽  
Chromatographic Analysis ◽  
Mobile Phase ◽  
Chromatographic Method ◽  
Reversed Phase ◽  
Limit Of Determination ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic ◽  
Control Samples

Abstract A liquid chromatographic method is described for the determination of cymiazole residues in honey. This acaricide is determined on a reversed-phase (C18) column, with a CH3CN-O.OOIN HCI-NaCI mixture (950 mL + 50 mL + 0.3 g/L) as the mobile phase, and UV detection at 265 nm. Cymiazole is extracted with n-hexane from aqueous alkalinized (pH 9) honey solutions. No further cleanup of the honey extract was required before chromatographic analysis. Recoveries on control samples fortified with 0.01,0.10, and 1.00 ppm cymiazole ranged from 92 to 102%. The limit of determination was 0.01 ppm.

Liquid chromatographic analysis of disopyramide and its mono-N-dealkylated metabolite.

1979 ◽  
Vol 25 (3) ◽  
pp. 405-408 ◽  
Author(s):  
J J Lima
Keyword(s):  
Chromatographic Analysis ◽  
Mobile Phase ◽  
High Performance ◽  
Antiarrhythmic Drugs ◽  
Internal Standard ◽  
High Performance Liquid Chromatographic ◽  
Coefficients Of Variation ◽  
Liquid Chromatographic Analysis ◽  
Liquid Chromatographic ◽  
Lower Limits

Abstract We describe a rapid, sensitive, and specific "high performance" liquid chromatographic analysis for disopyramide and its mono-N-dealkylated metabolite in serum, urine, and saliva. We used a mu-Bondapak CN column and an acetate buffer mobile phase containing methanol. Retention times for the two compounds and the internal standard, p-chlorodisopyramide, were 3.4, 4.1, and 6.3 min, respectively. The lower limits of sensitivity for drug and metabolite were 50 and 80 micrograms/L, respectively, with maximum coefficients of variation of 4.6 and 12%, respectively. Currently used antiarrhythmic drugs did not interfere with the analysis of disopyramide, and the pharmacokinetics of the drug, obtained from studies of one subject, agree well with reported values.

Paper Chromatographic Analysis of Chlorophenoxy Acids and Esters in Wheat

1964 ◽  
Vol 47 (2) ◽  
pp. 343-345
Author(s):  
George Yip
Keyword(s):  
Liquid Chromatography ◽  
Paper Chromatography ◽  
Chromatographic Analysis ◽  
Mobile Phase ◽  
Mineral Oil ◽  
Gas Liquid Chromatography ◽  
Immobile Phase ◽  
Rf Values ◽  
Chlorophenoxy Acids

Abstract 2,4-D, MCP, 2,4-DB, 2,4,5-T, 2,4,5-TP, and esters of 2,4-D can be detected as residues on wheat by paper chromatography after cleanup. The cleaned up samples are also suitable for analysis by gas-liquid chromatography. Rf values are presented for each chlorophenoxy acid and ester. Dimethylformamide in ether (35%) as immobile phase and 2,2,4-trimethylpentane as mobile phase give better resolution of the methylated acids than 10% mineral oil in ether (immobile phase) and 50% acetonitrile in water (mobile phase).

scholarly journals The Role of Fluorinated Alcohols as Mobile Phase Modifiers for LC-MS Analysis of Oligonucleotides

2016 ◽  
Vol 28 (1) ◽  
pp. 190-199 ◽  
Author(s):  
Babak Basiri ◽  
Hilde van Hattum ◽  
William D. van Dongen ◽  
Mandi M. Murph ◽  
Michael G. Bartlett
Keyword(s):  
Mobile Phase ◽  
Mobile Phase Modifiers ◽  
Ms Analysis ◽  
Fluorinated Alcohols

scholarly journals 670. Probing the Stability of rAAV Capsids and Genomic Constructs Using Differential Scanning Calorimetry in Concert With Mobile Phase Modifiers

2015 ◽  
Vol 23 ◽  
pp. S267
Author(s):  
James D. Maratt ◽  
Samantha F. Povlich ◽  
Christopher J. Morrison ◽  
Gwendolyn M. Wilmes ◽  
Samuel C. Wadsworth ◽  
...  
Keyword(s):  
Differential Scanning Calorimetry ◽  
Mobile Phase ◽  
Scanning Calorimetry ◽  
Mobile Phase Modifiers ◽  
The Stability
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