Use of the serum copper/zinc ratio in the differential diagnosis of ovarian malignancy.

1986 ◽  
Vol 32 (1) ◽  
pp. 101-103 ◽  
Author(s):  
A Lightman ◽  
J M Brandes ◽  
N Binur ◽  
A Drugan ◽  
O Zinder
Keyword(s):  
Malignant Tumor ◽  
Ovarian Tumor ◽  
Tumor Tissue ◽  
Pelvic Mass ◽  
Serum Copper ◽  
Copper And Zinc ◽  
Malignant Ovarian Tumor ◽  
Copper Zinc ◽  
The Mean ◽  
Benign Group

Abstract We measured copper and zinc in serum (n = 82) and tumor tissue (n = 41) from women with a palpable pelvic mass, admitted for suspected ovarian tumor. In serum, copper was increased and zinc decreased in the group (n = 40) subsequently proven to have a malignant ovarian tumor. The mean copper/zinc ratio in this group was 2.30 (SD 0.41), significantly (p less than 0.001) higher than for the benign group (n = 42), 1.43 (SD 0.22). In tumor tissue the concentrations of copper and zinc followed the same pattern, the copper/zinc ratio being significantly (p less than 0.001) higher in the malignant (0.158, SD 0.065) tumors than in the benign tissue (0.093, SD 0.04). We conclude that the Cu/Zn ratio in serum reliably (specifically) indicates the presence of advanced ovarian malignant tumor. The decreased concentrations of zinc and the increased concentrations of copper in serum do not seem to result from a shift of zinc into or release of copper out of the malignant tumor tissue.

Serum copper and zinc levels and copper/zinc ratio in patients with breast cancer

1994 ◽  
Vol 40 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Idris Yücel ◽  
Fikret Arpaci ◽  
Ahmet Özet ◽  
Bülent Döner ◽  
Turan Karayilanoĝlu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Serum Copper ◽  
Copper And Zinc ◽  
Copper Zinc ◽  
Zinc Levels

scholarly journals Ovarian fibrothecoma: An uncommon cause of a large pelvic mass

2016 ◽  
Author(s):  
Nikita Kumari ◽  
Reenu Kanwar ◽  
Bindu Bajaj ◽  
Garima Kapoor
Keyword(s):  
Ovarian Tumor ◽  
Histopathological Examination ◽  
Wide Spectrum ◽  
Pelvic Mass ◽  
Mass Effect ◽  
Left Ovary ◽  
Cystic Tumor ◽  
Normal Limits ◽  
Malignant Ovarian Tumor ◽  
Cystic Changes

Introduction: Ovarian fibrothecomas represent an ovarian stromal neoplasm developing in a wide spectrum of clinical settings. These tumors have been described as rare ovarian neoplasm, accounting for about 4% of all ovarian tumors. We report a case whose clinical presentation was highly deceptive and was clinically and radiologically diagnosed as malignant ovarian tumor. Ascitic fluid cytology revealed absence of malignant cells. On histopathological examination, it was diagnosed as benign fibrothecoma with cystic changes. Postoperative follow-up for about six months was uneventful. Case: A 45 year old female presented to the gynae emergency with large abdominal lump of 20 weeks size with acute pain abdomen. She was admitted for initial management and thorough evaluation. Hematological and biochemical parameters were within normal limits. USG revealed a large multilocular, predominantly cystic lesion 20.9x9.6x11.4 cm in pelvis. CECT revealed ovarian cystadencarcinoma left ovary with locoregional mass effect, mild ascites and suspicious metastasis to internal iliac lymph nodes. Radiological and preoperative clinical diagnosis was malignant ovarian tumor. Panhysterectomy and omentectomy was performed. On gross examination, a well encapsulated, multinodular cystic tumor of left ovary about 17x14x7 cm was identified. Cut surface was mostly solid with few cystic areas. Uterus, cervix, right ovary and both tubes were unremarkable. On microscopic examination, multiple sections showed spindle shaped cells in storiform and palisading pattern. No mitotic activity was identified. On special staining, it was positive for vimentin, which is a characteristic feature of ovarian fibrothecoma. Conclusion: The accurate preoperative diagnosis of ovarian fibrothecoma with cystic changes could have prevented the extensive surgical intervention such as bilateral salpingo- oopherectomy with hysterectomy.

scholarly journals Estimation of Serum Copper and Zinc Levels in Oral Submucous Fibrosis: An Atomic Absorption Spectroscopic Study

2013 ◽  
Vol 14 (5) ◽  
pp. 801-805 ◽  
Author(s):  
H Neethi
Keyword(s):  
Spectroscopic Study ◽  
Atomic Absorption ◽  
Oral Submucous Fibrosis ◽  
Serum Copper ◽  
Stage I ◽  
Healthy Controls ◽  
Copper And Zinc ◽  
Submucous Fibrosis ◽  
The Mean ◽  
Zinc Levels

ABSTRACT Background and objectives Biochemical derangements of microelements although reported in oral cancer is poorly understood in oral submucous fibrosis (OSMF). Hence, the present study was carried out to estimate and compare the serum copper and zinc levels among different histopathological stages of OSMF with that of healthy controls. Materials and methods Thirty histopathologically diagnosed cases of OSMF and 30 healthy controls reporting to MS Ramaiah Dental College and Hospital (MSRDCH), Bengaluru, were included in the study. The histopathological staging of OSMF was done as per criteria given by Pindborg and Sirsat (1966). Blood samples were collected and the serum copper and zinc levels were estimated using atomic absorption spectroscopy. The results were statistically analyzed using independent t-test and Kruskal-Wallis test. Results The mean serum copper levels were increased (p < 0.0005) and zinc levels were decreased (p < 0.01) in OSMF patients when compared to that of controls. The mean serum copper levels showed an increasing trend from stage I to IV (p = 0.004) while zinc levels showed a decreasing trend from stage I to IV (p = 0.04) in OSMF patients. Conclusion The serum copper and zinc levels in OSMF showed a significant difference in comparison to that of controls and between the histopathological stages. These findings indicate that serum copper and zinc may have a contributory role in the etiopathogenesis of OSMF. Clinical relevance Although the role of the trace elements as etiological factors is minor, derangements noted in the serum copper and zinc levels could be correlated with diseased progression and possibly explain the transformation of OSMF into malignancy. Thus, they can be used as prognostic markers and can be of value for proactive intervention. How to cite this article Neethi H, Patil S, Rao RS. Estimation of Serum Copper and Zinc Levels in Oral Submucous Fibrosis: An Atomic Absorption Spectroscopic Study. J Contemp Dent Pract 2013;14(5):801-805.

scholarly journals Copper-To-Zinc Ratio as an Inflammatory Marker in Patients with Sickle Cell Disease

Sci ◽  
2020 ◽  
Vol 2 (4) ◽  
pp. 89
Author(s):  
Mathias Abiodun Emokpae ◽  
Emmanuel Bamidele Fatimehin
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Serum Levels ◽  
Serum Copper ◽  
The Body ◽  
Zinc Homeostasis ◽  
Clinical State ◽  
Cell Disease ◽  
Copper And Zinc ◽  
Copper Zinc

Sickle cell disease (SCD) is an inherited disorder and a major health challenge in Nigeria. Micronutrient deficiencies often associated with the disorder may cause inflammation and abnormal metabolism in the body. The copper-to-zinc ratio is a more relevant diagnostic measure than the concentration of either metal alone in clinical practice. This study seeks to evaluate serum levels of c-reactive protein (CRP), copper, zinc and the copper-to-zinc ratio, and to correlate the latter with CRP in adult subjects with SCD. Serum copper, zinc, CRP and plasma fibrinogen were assayed in 100 confirmed SCD patients in steady clinical state and 100 age- and sex-matched subjects with normal hemoglobin. Serum copper and zinc were assayed by the colorimetric method using reagents supplied by Centronic, Germany, while CRP and fibrinogen were assayed using reagents supplied by Sigma (St. Louis, MO, USA) and Anogen (Ontario, Canada), respectively. The copper-to-zinc ratio was calculated from serum levels of copper and zinc. The measured parameters were compared between the groups using the Students t-test, and the Pearson correlation coefficient was used to relate CRP with the other parameters. Serum copper, CRP, fibrinogen and the copper-to-zinc ratio were significantly higher (p < 0.001), while zinc level was lower in SCD patients than in controls. Serum CRP concentration correlated with copper (r = 0.10; p < 0.02), zinc (r = −0.199; p < 0.05) and the copper-to-zinc ratio (r = 0.312; p < 0.002), but the correlation between CRP and fibrinogen was not significant. Inflammation may modulate copper and zinc homeostasis, and the copper-to-zinc ratio may be used as a marker of nutritional deficiency and inflammation in SCD patients.

scholarly journals Sclerosing Stromal Tumor of Ovary: A Case Report

2017 ◽  
Vol 1 (1) ◽  
pp. 83-86
Author(s):  
R. Rana ◽  
S.U. Kafle ◽  
K.K. Jha ◽  
M. Singh ◽  
P. Gautam
Keyword(s):  
Ovarian Tumor ◽  
Past History ◽  
Young Patients ◽  
Pelvic Mass ◽  
Stromal Tumor ◽  
Histopathological Diagnosis ◽  
Malignant Ovarian Tumor ◽  
History Of ◽  
Sclerosing Stromal Tumor ◽  
Sex Cord Stromal Tumors

A case of 32 year old female of pelvic pain for one month and with past history of hysterectomy performed two year back. Clinical examination revealed palpable abdominal pelvic mass. Ultrasonography showed right pelvic mass arising from right adnexa measuring 15cm x 15 cm, predominantly solid with some cystic areas. The patient was suspected of having a malignant ovarian tumor and hence operated. A histopathological diagnosis revealed sclerosing stromal tumor of ovary. Sex cord-stromal tumors account for approximately 8% of all ovarian tumor and prevalence of sclerosing stromal tumor of ovary is 1.5% to 6% .This rare neoplasm is not always possible to predict pre-operatively on the basis of clinical and radiological findings. Histologically, it is characterized by several unique features including pseudolobulation, sclerosis, and prominent vascularity. Sclerosing stromal tumor is rare but possibility of this tumor should be considered in young patients with ovarian mass having the characteristic histopathological morphology.Birat Journal of Health Sciences 2016 1(1): 83-86

scholarly journals Serum Copper and Zinc Levels and Risk of Hepatocellular Carcinoma: A 1:1 Matched Case-Control Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1397-1397
Author(s):  
Aiping Fang ◽  
Huilian Zhu
Keyword(s):  
Serum Zinc ◽  
Serum Levels ◽  
Case Control ◽  
Serum Copper ◽  
Copper And Zinc ◽  
Copper Zinc ◽  
Matched Case ◽  
Zinc Levels ◽  
Control Study ◽  
Serum Zinc Levels

Abstract Objectives Copper and zinc have been involved in the development of liver cancer in laboratory models, yet data from epidemiological studies are limited. We investigated the association of serum levels of copper and zinc and their ratio with the risk of hepatocellular carcinoma (HCC) in a Chinese population. Methods This is a 1:1 matched case-control study conducted between September 2013 and February 2017. Each case with newly diagnosed HCC from the Guangdong Liver Cancer Cohort (GLCC) was matched to one healthy control from the Guangzhou Nutrition and Health Study by age (±1 years) and sex. Serum copper and zinc levels were quantified using inductively coupled plasma mass spectrometry. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age, sex, body mass index, hepatitis infection, smoking status, alcohol drinking status, diabetes, and chronic inflammation. Serum levels of copper and zinc and their ratio were included in models in tertiles with cutpoints based on the distribution of the control participants. Results A total of 556 case-control pairs were included in this study. Mean (SD) age was 60.3 (7.1) years and 83.8% of the participants were men. HCC cases had significantly higher copper and lower zinc levels, and thus higher copper/zinc, than controls. Higher serum zinc levels were associated with a lower risk of HCC (ORT3 vs T1 = 0.21; 95% CI: 0.07–0.64, P for trend = 0.005). However, there was no association between serum copper levels and HCC risk (ORT3 vs T1 = 1.53; 95% CI: 0.62–3.76, P for trend = 0.375). Higher copper/zinc ratio was associated with increased risk of HCC (ORT3 vs T1 = 3.06; 95% CI: 1.08–8.70, P for trend = 0.049). Conclusions Serum zinc levels were inversely associated with the risk of HCC, suggesting a protective role of zinc in preventing HCC development. Funding Sources This work was supported by the National Natural Science Foundation of China.

Copper-to-Zinc Ratio Correlates with an Inflammatory Marker in Patients with Sickle Cell Disease (Version 1)

Sci ◽  
2019 ◽  
Vol 1 (2) ◽  
pp. 34
Author(s):  
Mathias Abiodun Emokpae ◽  
Emmanuel Babatunde Fatimehin
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Serum Levels ◽  
Serum Copper ◽  
The Body ◽  
Zinc Homeostasis ◽  
Clinical State ◽  
Cell Disease ◽  
Copper And Zinc ◽  
Copper Zinc

Sickle cell disease (SCD) is an inherited disorder of major health challenge in Nigeria. Micronutrients deficiencies often associated with the disorder may cause inflammation and abnormal metabolisms in the body. The copper-to-zinc ratio is a more important assessment than the concentrations of either of the metals in clinical practice. This study seeks to evaluate serum levels of c-reactive protein (CRP), copper, zinc and copper-to-zinc ratio and to correlate copper-to-zinc ratio with CRP in adult subjects with SCD. Serum copper, zinc, CRP and plasma fibrinogen were assayed in 100 confirmed SCD patients in steady clinical state and 100 age and sex matched subjects with normal haemoglobin. Serum copper and zinc were assayed by colorimetric method using reagents supplied by Centronic, Germany while CRP and fibrinogen were assayed using reagents supplied by Sigma (St. Louis, MO, USA) and Anogen (Ontario, Canada), respectively. The copper to zinc ratio was calculated from serum levels of copper and zinc. The measured parameters were compared between the groups using Students t-test and Pearson correlation coefficient was used to relate CRP with the other parameters. Serum copper, CRP, fibrinogen and copper-to-zinc ratio were significantly higher (p < 0.001) while zinc level was lower in SCD patients than controls. Serum CRP concentration correlated with copper (r = 0.10; p < 0.02), zinc (r = −0.199; p < 0.05) and Copper-to-zinc ratio (r = 0.312; p < 0.002) but the correlation between CRP and fibrinogen was not significant. Inflammatory condition may modulate copper and zinc homeostasis and copper-to-zinc ratio may be used as marker of nutritional deficiency and inflammation in SCD patients.

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