Reference intervals for plasma lipoperoxides: age-, sex-, and specimen-related variations.

1987 ◽  
Vol 33 (12) ◽  
pp. 2289-2291 ◽  
Author(s):  
J A Knight ◽  
S E Smith ◽  
V E Kinder ◽  
H B Anstall
Keyword(s):  
Older Women ◽  
Young Women ◽  
Blood Donors ◽  
Sodium Citrate ◽  
Older Men ◽  
Reference Intervals ◽  
Female Adult ◽  
Experimental Animals ◽  
Age Related ◽  
Younger Men

Abstract We measured lipoperoxides, as malondialdehyde (MDA), by liquid chromatography in plasma from 230 male and 148 female adult blood donors, to establish reliable reference values and to compare possible sex-, age-, and specimen-related differences. Our studies show that mean have higher MDA concentrations in plasma than do women (P less than 0.05), older men have higher values than younger men (P less than 0.05), and older women have higher values than young women (P less than 0.001). These age-related results support earlier studies in experimental animals that lipid peroxidation increases with increasing age. In addition, plasma from liquid EDTA-anti-coagulated blood has significantly lower MDA concentrations than does serum or plasma from blood treated with lithium heparin, sodium citrate, or CPDA-1 (P less than 0.001).

Age and gender interactions on verbal memory performance

2003 ◽  
Vol 9 (1) ◽  
pp. 97-102 ◽  
Author(s):  
JOEL H. KRAMER ◽  
KRISTINE YAFFE ◽  
JEANNE LENGENFELDER ◽  
DEAN C. DELIS
Keyword(s):  
Older Women ◽  
Verbal Memory ◽  
Memory Performance ◽  
Older Men ◽  
Age And Gender ◽  
Younger Women ◽  
Age Related ◽  
Younger Men ◽  
And Gender ◽  
Gender Interactions

Age and gender effects on verbal episodic memory are well established. However, the possibility of interactions between age and gender has been raised by studies linking estrogen and verbal memory performance, and by research suggesting gender differences in age-related cortical atrophy. We evaluated whether age by gender interactions in verbal memory were present. Subjects within three years of the median age of menopause were excluded from a large cohort of normal subjects, resulting in a younger sample (16–47 years) of 288 men and 285 women, and an older sample (55–89 years) of 201 men and 245 women. All subjects were administered the CVLT-2, a multiple-trial list-learning task. Verbal memory was negatively correlated with age for younger men, older men, and older women, but not for younger women. Multivariate analyses indicated age by gender interactions on memory for the younger group but not the older group. Results indicate that verbal memory declines with age for younger men but not younger women, whereas both older men and older women show age-related declines. These findings are consistent with hypotheses linking estrogen and verbal memory performance, and with imaging data suggesting that age-related hippocampal atrophy is found in younger men but not younger women. The role of estrogen on cognition in normal aging warrants further study. (JINS, 2003, 9, 97–102.)

Wife Killing: Risk to Women as a Function of Age

2000 ◽  
Vol 15 (3) ◽  
pp. 273-282 ◽  
Author(s):  
Todd K. Shackelford ◽  
David M. Buss ◽  
Jay Peters
Keyword(s):  
Older Women ◽  
Young Women ◽  
Older Men ◽  
Elevated Risk ◽  
Excess Risk ◽  
Reproductive Age ◽  
Reproductive Value ◽  
Younger Women ◽  
Reproductive Age Women ◽  
Younger Men

Younger women, relative to older women, incur elevated risk of uxoricide—being murdered by their husbands. Some evolutionary theorists attribute this pattern to men’s evolved sexual proprietariness, which inclines them to use violence to control women, especially those high in reproductive value. Other evolutionary theorists propose an evolved homicide module for wife killing. An alternative to both explanations is that young women experience elevated uxoricide risk as an incidental byproduct of marriage to younger men who commit the majority of acts of violence. We used a sample of 13,670 uxoricides to test these alternative explanations. Findings show that (a) reproductive-age women incur an elevated risk of uxoricide relative to older women; (b) younger men are overrepresented among uxoricide perpetrators; and (c) younger women, even when married to older men, still incur excess risk of uxoricide. Discussion examines competing explanations for uxoricide in light of these findings.

Influences of age and gender on human thermoregulatory responses to cold exposures

1985 ◽  
Vol 58 (1) ◽  
pp. 180-186 ◽  
Author(s):  
J. A. Wagner ◽  
S. M. Horvath
Keyword(s):  
Older Women ◽  
Body Fat ◽  
Young Women ◽  
Cold Exposure ◽  
Physiological Responses ◽  
Metabolic Cost ◽  
Older Men ◽  
Age And Gender ◽  
Younger Women ◽  
And Gender

To delineate age- and gender-related differences in physiological responses to cold exposure, men and women between the ages of 20 and 29 yr and 51 and 72 yr, wearing minimal clothing, were exposed at rest for 2 h to 28, 20, 15, and 10 degrees C room temperatures with 40% relative humidity. During the coldest exposure, the rates of increase in metabolic rate (W X m-2 or ml X kg lean body mass-1 X min-1 were similar for all groups. However, older women (n = 7) may have benefited from a larger (P less than 0.05) early metabolic (M) increase (40% within 15 min) than young men (18%) (n = 10), young women (5%) (n = 10), or older men (5%) (n = 10). A similar rapid M response in older women occurred during the 15 degrees C exposure. During all cold exposures, older women maintained constant rectal temperature (Tre) and young women maintained Tre only during the 20 degrees C exposures, whereas Tre of the men declined during all cold exposures (P less than 0.01). Changes in Tre and mean skin temperature (Ts) during cold exposure were largely related to body fat, although age and surface area/mass modified the changes in men. The data suggest that older men are more susceptible to cold ambients than younger people, since they did not prevent a further decline in their initially relatively low Tre. Despite greater insulation from body fat, the older women maintained a constant Tre at greater metabolic cost than men or younger women.

scholarly journals Age-Related Differences in Muscle Synergy Organization during Step Ascent at Different Heights and Directions

2020 ◽  
Vol 10 (6) ◽  
pp. 1987 ◽  
Author(s):  
Remco J. Baggen ◽  
Jaap H. van Dieën ◽  
Evelien Van Roie ◽  
Sabine M. Verschueren ◽  
Georgios Giarmatzis ◽  
...  
Keyword(s):  
Motor Control ◽  
Older Women ◽  
Young Women ◽  
Age Groups ◽  
Neuromuscular Control ◽  
Significant Negative Correlation ◽  
Community Dwelling ◽  
Step Height ◽  
Muscle Synergy ◽  
Age Related

The aim of this study was to explore the underlying age-related differences in dynamic motor control during different step ascent conditions using muscle synergy analysis. Eleven older women (67.0 y ± 2.5) and ten young women (22.5 y ± 1.6) performed stepping in forward and lateral directions at step heights of 10, 20 and 30 cm. Surface electromyography was obtained from 10 lower limb and torso muscles. Non-negative matrix factorization was used to identify sets of (n) synergies across age groups and stepping conditions. In addition, variance accounted for (VAF) by the detected number of synergies was compared to assess complexity of motor control. Finally, correlation coefficients of muscle weightings and between-subject variability of the temporal activation patterns were calculated and compared between age groups and stepping conditions. Four synergies accounted for >85% VAF across age groups and stepping conditions. Age and step height showed a significant negative correlation with VAF during forward stepping but not lateral stepping, with lower VAF indicating higher synergy complexity. Muscle weightings showed higher similarity across step heights in older compared to young women. Neuromuscular control of young and community-dwelling older women could not be differentiated based on the number of synergies extracted. Additional analyses of synergy structure and complexity revealed subtle age- and step-height-related differences, indicating that older women rely on more complex neuromuscular control strategies.

scholarly journals The interaction of age and gender in illness narratives

2008 ◽  
Vol 28 (7) ◽  
pp. 1025-1045 ◽  
Author(s):  
CLIVE SEALE ◽  
JONATHAN CHARTERIS-BLACK
Keyword(s):  
Older Women ◽  
Medical Information ◽  
Elderly Care ◽  
Age Groups ◽  
Older Men ◽  
Family Networks ◽  
Emotional Dimension ◽  
Younger Men ◽  
Research Interviews ◽  
And Gender

ABSTRACTRecognition of the greater capacity of older women to draw on supportive social networks has now supplemented an earlier focus of research into gender and ageing which portrayed older men as a ‘privileged gerontocracy’ because of their greater access to financial resources and spousal care. This study of the experiences of cancer among people of three different age groups conducted a comparative keyword analysis of their narratives to consider the gender differentiation of a third resource: access to medical information and personnel. The analysed narratives were sampled from a large archive of research interviews. It was found that older men with cancer demonstrated a greater involvement with medicine as an expert system than younger men or women or older women. This stemmed from their social confidence when interacting with doctors and their interest in treating their illness as a ‘problem’ to be fixed with medico-scientific solutions. Compared with younger men and women of all ages, older men were less likely to draw on informal social and family networks for support, or to discuss in a direct style the emotional dimension of illness experience. Our findings contrast with other studies that have reported linguistic disadvantage in older people in elderly care settings, which underlines the importance of context for linguistic studies.

Temperament and Personality as Functions of Age

1996 ◽  
Vol 42 (4) ◽  
pp. 251-269 ◽  
Author(s):  
Albert Mehrabian ◽  
Jeffrey S. Blum
Keyword(s):  
Older Women ◽  
Psychological Adjustment ◽  
Older Persons ◽  
Older Men ◽  
Men And Women ◽  
Age Related ◽  
Older Men And Women ◽  
Temperament Trait

Age-related differences in three temperament (Trait Pleasure-displeasure, Trait Arousability, Trait-Dominance-submissiveness), and four personality (Achieving Tendency, Conformity, Shyness, Loneliness), scales were explored in three studies. Results, generally, were consistent with the hypothesis that scores on Trait Dominance and on trait measures that correlated positively with Trait Dominance (e.g., achievement) were lower for older persons. Achieving Tendency (assessed in Studies One and Three) was lower for older persons. Trait Dominance (assessed in 2 studies) was lower for older men and women in Study Two and lower for older women only in Study Three. In Study Three, two strong negative correlates of Trait Dominance (Conformity, Shyness) were higher for older women. Based on a consistent absence of age/Trait Pleasure relationships, no age-related differences in psychological adjustment-maladjustment were implied by the findings.

scholarly journals A Content Analysis of Testosterone Websites: Sex, Muscle, and Male Age-Related Thematic Differences

2017 ◽  
Vol 12 (2) ◽  
pp. 388-397 ◽  
Author(s):  
Nicholas Ivanov ◽  
Jimmy Vuong ◽  
Peter B. Gray
Keyword(s):  
Life History ◽  
Well Being ◽  
Older Men ◽  
The United States ◽  
Home Pages ◽  
Behavioral Endocrinology ◽  
Online Sales ◽  
Age Related ◽  
Younger Men ◽  
Over 40 Years

Male testosterone supplementation is a large and growing industry. How is testosterone marketed to male consumers online? The present exploratory study entailed a content coding analysis of the home pages of 49 websites focused on testosterone supplementation for men in the United States. Four hypotheses concerning anticipated age-related differences in content coding were also tested: more frequent longevity content toward older men, and more frequent social dominance/physical formidability, muscle, and sex content toward younger men. Codes were created based on inductive observations and drawing upon the medical, life history, and human behavioral endocrinology literatures. Approximately half ( n = 24) of websites were oriented toward younger men (estimated audience of men 40 years of age or younger) and half ( n = 25) toward older men (estimated audience over 40 years of age). Results indicated that the most frequent content codes concerned online sales (e.g., product and purchasing information). Apart from sales information, the most frequent codes concerned, in order, muscle, sex/sexual functioning, low T, energy, fat, strength, aging, and well-being, with all four hypotheses also supported. These findings are interpreted in the light of medical, evolutionary life history, and human behavioral endocrinology approaches.

scholarly journals Effect of aging on carotid baroreflex control of blood pressure and leg vascular conductance in women

2014 ◽  
Vol 306 (10) ◽  
pp. H1417-H1425 ◽  
Author(s):  
Daniel P. Credeur ◽  
Seth W. Holwerda ◽  
Leryn J. Boyle ◽  
Lauro C. Vianna ◽  
Areum K. Jensen ◽  
...  
Keyword(s):  
Older Women ◽  
Young Women ◽  
Vascular Changes ◽  
Vascular Conductance ◽  
Response Latencies ◽  
Baroreflex Control ◽  
Age Related ◽  
Carotid Baroreflex ◽  
Duplex Doppler ◽  
Neck Pressure

Recent work suggests that β-adrenergic vasodilation offsets α-adrenergic vasoconstriction in young women, but this effect is lost after menopause. Given these age-related vascular changes, we tested the hypothesis that older women would exhibit a greater change in vascular conductance following baroreflex perturbation compared with young women. In 10 young (21 ± 1 yr) and 10 older (62 ± 2 yr) women, mean arterial pressure (MAP; Finometer), heart rate (HR), cardiac output (CO; Modelflow), total vascular conductance (TVC), and leg vascular conductance (LVC, duplex-Doppler ultrasound) were continuously measured in response to 5-s pulses of neck suction (NS; −60 Torr) and neck pressure (NP; +40 Torr) to simulate carotid hypertension and hypotension, respectively. Following NS, decreases in MAP were similar between groups; however, MAP peak response latency was slower in older women ( P < 0.05). Moreover, at the time of peak MAP, increases in LVC (young, −11.5 ± 3.9%LVC vs. older, +19.1 ± 7.0%LVC; P < 0.05) and TVC were greater in older women, whereas young women exhibited larger decreases in HR and CO (young, −10 ± 3% CO vs. older, +0.8 ± 2% CO; P < 0.05). Following NP, increases in MAP were blunted (young, +14 ± 1 mmHg vs. older, +8 ± 1 mmHg; P < 0.05) in older women, whereas MAP response latencies were similar. Interestingly, decreases in LVC and TVC were similar between groups, but HR and CO (young, +7.0 ± 2% CO vs. older, −4.0 ± 2% CO; P < 0.05) responses were attenuated in older women. These findings suggest that older women have greater reliance on vascular conductance to modulate MAP via carotid baroreflex, whereas young women rely more on cardiac responsiveness. Furthermore, older women demonstrate a blunted ability to increase MAP to hypotensive stimuli.

Oropharyngeal Swallow in Younger and Older Women

2002 ◽  
Vol 45 (3) ◽  
pp. 434-445 ◽  
Author(s):  
Jeri A. Logemann ◽  
Barbara Roa Pauloski ◽  
Alfred W. Rademaker ◽  
Peter J. Kahrilas
Keyword(s):  
Range Of Motion ◽  
Older Women ◽  
Young Women ◽  
Kinematic Analysis ◽  
Slow Motion ◽  
Older Men ◽  
Published Data ◽  
Aging Effects ◽  
Swallowing Function ◽  
Effects Of Aging

Much of the initial research on normal swallowing has been conducted in young men. Recently, there has been increasing interest in determining whether there are differences between the sexes in swallowing function and in the effects of aging on swallowing in both sexes. This investigation examined the swallowing ability of 8 healthy young women between the ages of 21 and 29 and 8 healthy older women between the ages of 80 and 93 during two swallows each of 1 ml and 10 ml liquid boluses. Videofluoroscopic studies of these swallows were reviewed in slow motion and real time to confirm the absence of swallowing disorders. Kinematic analysis of each swallow was completed. Data on range of motion of pharyngeal structures and coordination characteristics of the oropharyngeal swallow were taken from this kinematic analysis. Position of the larynx at rest and length of neck were compared between the two groups. Data from this study were compared with previously published data on younger and older men. Interestingly, the range of motion of the older women was often greater than that of the young women. Only tongue base movement diminished significantly with age in women. Volume effects observed in duration and extent of movement during the 1 ml and 10 ml swallows were similar to those in earlier studies. Older women also exhibited an increased range of motion relative to the old men. This increase may indicate a compensation for aging effects not seen in older men.

Hemodynamics and brain blood flow during posture change in younger women and postmenopausal women compared with age-matched men

2012 ◽  
Vol 112 (9) ◽  
pp. 1482-1493 ◽  
Author(s):  
H. Edgell ◽  
A. D. Robertson ◽  
R. L. Hughson
Keyword(s):  
Older Women ◽  
Young Women ◽  
Stroke Volume Index ◽  
Older Men ◽  
Volume Index ◽  
Men And Women ◽  
Younger Women ◽  
End Tidal ◽  
Older Men And Women ◽  
Forearm Vascular Resistance

Increased incidence of orthostatic hypotension and presyncopal symptoms in young women could be related to hormonal factors that might be isolated by comparing cardiovascular and cerebrovascular responses to postural change in young and older men and women. Seven young women, 11 young men, 10 older women (>1 yr postmenopausal, no hormone therapy), and 9 older men participated in a supine-to-sit-to-stand test while measuring systemic hemodynamics, end-tidal Pco2, and blood flow velocity of the middle cerebral artery (MCA). Women had a greater reduction in stroke volume index compared with age-matched men (change from supine to standing: young women: −22.9 ± 1.6 ml/m2; young men: −14.4 ± 2.4 ml/m2; older women: −17.4 ± 3.3 ml/m2; older men: −13.8 ± 2.2 ml/m2). This was accompanied by offsetting changes in heart rate, particularly in young women, resulting in no age or sex differences in cardiac output index. Mean arterial pressure (MAP) was higher in older subjects and increased with movement to upright postures. Younger men and women had higher forearm vascular resistance that increased progressively in the upright posture compared with older men and women. There was no difference between sexes or ages in total peripheral resistance index. Women had higher MCA velocity, but both sexes had reduced MCA velocity while upright, which was a function of reduced blood pressure at the MCA and a significant reduction in end-tidal Pco2. The reductions in stroke volume index suggested impaired venous return in women, but augmented responses of heart rate and forearm vascular resistance protected MAP in younger women. Overall, these results showed significant sex and age-related differences, but compensatory mechanisms preserved MAP and MCA velocity in young women.

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