Electrophoretic examination of proteinuria in Lowe's syndrome and other causes of renal tubular Fanconi syndrome.

1989 ◽  
Vol 35 (11) ◽  
pp. 2231-2233 ◽  
Author(s):  
N M Papadopoulos ◽  
R Costello ◽  
L Charnas ◽  
M D Adamson ◽  
W A Gahl
Keyword(s):  
Metabolic Disorders ◽  
Fanconi Syndrome ◽  
Gamma Globulin ◽  
Urine Samples ◽  
Agarose Gel ◽  
Urinary Proteins ◽  
Urine Protein ◽  
Zone Electrophoresis ◽  
Idiopathic Fanconi Syndrome ◽  
Renal Tubular

Abstract Urine samples from 26 patients with five different causes of renal tubular Fanconi syndrome were examined by zone electrophoresis on agarose gel and immunofixation. The tubular disorders associated with Lowe's syndrome, cystinosis, and idiopathic Fanconi syndrome exhibited urine protein electrophoretic characteristics that differentiated them from normal and from each other. In particular, Lowe's syndrome urine exhibited four discrete bands in the gamma globulin zone. Electrophoresis of urinary proteins may be useful in distinguishing among the different metabolic disorders causing renal tubular Fanconi syndrome.

Comparison of several methods for semiquantitative determination of urinary protein.

1977 ◽  
Vol 23 (5) ◽  
pp. 876-879 ◽  
Author(s):  
W L Gyure
Keyword(s):  
Serum Albumin ◽  
Salt Concentration ◽  
Urine Samples ◽  
Urine Protein ◽  
Sulfosalicylic Acid ◽  
Green Method ◽  
Semiquantitative Determination ◽  
Acid Method ◽  
Bromcresol Green

Abstract Two types of urine protein dipsticks and the sulfosalicylic acid method were compared for their accuracy and specificity, with use of urine samples supplemented with various proteins. Dipsticks yield accurate results when the protein under consideration is restricted to albumin; the sulfosalicylic acid method accurately determines many kinds of proteins in addition to albumin. Detergents affect each of the methods, but changes in salt concentration only affect results by dipstick procedures. Dipsticks, which are based on the protein-error principle for indicators, are subject to some of the conditions that apply to the bromcresol green method for serum albumin determination.

scholarly journals Autophagy activation reduces renal tubular injury induced by urinary proteins

Autophagy ◽  
2013 ◽  
Vol 10 (2) ◽  
pp. 243-256 ◽  
Author(s):  
Wei Jing Liu ◽  
Mian-Na Luo ◽  
Jin Tan ◽  
Wei Chen ◽  
Lei-zhao Huang ◽  
...  
Keyword(s):  
Tubular Injury ◽  
Urinary Proteins ◽  
Renal Tubular

scholarly journals Acute Lymphoblastic Leukemia Presenting as Fanconi Syndrome

2018 ◽  
Vol 11 (1) ◽  
pp. 63-67
Author(s):  
Tatsunori Yoshida ◽  
Hiroshi Tsujimoto ◽  
Takayuki Ichikawa ◽  
Shinji Kounami ◽  
Hiroyuki Suzuki
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Renal Tubular Acidosis ◽  
Fanconi Syndrome ◽  
Blood Smear ◽  
Lymphoblastic Leukemia ◽  
Peripheral Blood Smear ◽  
Leukemic Cells ◽  
Laboratory Examinations ◽  
Renal Tubular ◽  
Electrolyte Abnormalities

Acute lymphoblastic leukemia (ALL) presenting as Fanconi syndrome (FS) is extremely rare. Here, we report a case of ALL presenting as bilateral nephromegaly following FS. A 2-year-old girl was unexpectedly diagnosed with bilateral nephromegaly. After 2 weeks, she developed general fatigue, thirst, and polyuria. Laboratory examinations revealed renal tubular acidosis, hypokalemia, hypophosphatemia, and aminoaciduria, and FS was diagnosed. Replacement of bicarbonate and potassium did not improve her condition. Two weeks after the onset of FS, leukemic cells appeared on a peripheral blood smear, and the patient was diagnosed with precursor B-cell ALL presenting as nephromegaly and FS. Chemotherapy brought about a prompt resolution of acidosis and electrolyte abnormalities, without renal dysfunction. The patient remains well 4 years after the onset of the disease. Although extremely rare, FS should be recognized as one of the emerging renal complications of ALL.

DISEASES OF THE RENAL TUBULES IN CHILDHOOD

PEDIATRICS ◽  
1957 ◽  
Vol 20 (2) ◽  
pp. 337-357
Author(s):  
Carolyn F. Piel
Keyword(s):  
Fanconi Syndrome ◽  
Storage Disease ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Renal Tubules ◽  
Hyperchloremic Acidosis ◽  
Renal Glycosuria ◽  
Vitamin D Resistant Rickets ◽  
Renal Tubular ◽  
Resistant Rickets

As indicated in the preceding sections of this review, it seems evident that renal diabetes insipidus, renal glycosuria, "cystinuria" and renal hyperchloremic acidosis are unquestionably renal tubular diseases. Vitamin D resistant rickets has tentatively been placed in the same category although it is recognized that the evidence for this classification is not yet thoroughly convincing. All of the findings of the Fanconi syndrome seem actually to represent a summation of the single tubular diseases, except "cystinosis." Known renal tubular dysfunction fails to explain the cystine-storage disease, cystinosis.

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