scholarly journals Nephelometric determination of carbohydrate deficient transferrin

1996 ◽  
Vol 42 (4) ◽  
pp. 551-557 ◽  
Author(s):  
F Schellenberg ◽  
M Martin ◽  
E Cacès ◽  
J Y Bénard ◽  
J Weill
Keyword(s):  
Sialic Acid ◽  
Characteristic Curve ◽  
Anion Exchange Chromatography ◽  
Receiver Operator Characteristic Curve ◽  
Exchange Chromatography ◽  
Treatment Center ◽  
Serum Transferrin ◽  
Receiver Operator Characteristic ◽  
Carbohydrate Deficient Transferrin

Abstract We describe a technique for measuring carbohydrate-deficient transferrin (CDT) in serum. Serum transferrin fractions are separated by anion-exchange chromatography on microcolumns. Sialic acid-deficient transferrin fractions are collected in the eluate, and transferrin is then quantified by a rate-nephelometric technique. Imprecision (CV) was 4-5% within-run and 7-9% between runs (n = 15). Comparison with an isoelectric focusing-immunofixation method for transferrin index (x) yielded y = 761x + 7, Sy/x = 39 mg/L. Assay of sera from 90 abstainers or moderate consumers of alcohol showed that 81 (90%) had CDT concentrations between 30 and 70 mg/L. Among 74 alcoholics admitted to an alcohol treatment center, 54 (73%) had CDT > 70 mg/L, i.e., the diagnostic sensitivity was 73% at a specificity of 90% (area under receiver-operator characteristic curve = 0.891).

AVALIAÇÃO DE UM INSTRUMENTO DE MENSURAÇÃO DE MORBIDADE PSÍQUICA: ESTUDO DE VALIDAÇÃO DO SELF-REPORTING QUESTIONNAIRE (SRQ-20)

1970 ◽  
Vol 34 (3) ◽  
pp. 544 ◽  
Author(s):  
Kionna Oliveira Bernardes Santos ◽  
Tânia Maria de Araújo ◽  
Paloma de Sousa Pinho ◽  
Ana Cláudia Conceição Silva
Keyword(s):  
Characteristic Curve ◽  
Receiver Operator Characteristic Curve ◽  
Clinical Interview ◽  
Receiver Operator Characteristic ◽  
Interview Schedule ◽  
Para Determinar ◽  
Self Reporting Questionnaire

O Self-Reporting Questionnaire (SRQ-20), desenvolvido pela Organização Mundial de Saúde, tem sido utilizado para mensuração de nível de suspeição de transtornos mentais em estudos brasileiros, especialmente em grupos de trabalhadores. O objetivo deste estudo foi avaliar o desempenho do SRQ-20, com base em indicadores de validade (sensibilidade, especificidade, taxa de classificação incorreta e valores preditivos), e determinar o melhor ponto de corte para classificação dos transtornos mentais comuns na população estudada. O estudo incluiu 91 indivíduos selecionados aleatoriamente de um estudo de corte transversal realizado com população residente em áreas urbanas de Feira de Santana (BA). Entrevistas clínicas, realizadas por psicólogas, utilizando o Revised Clinical Interview Schedule (CIS-R), foi adotada como padrão-ouro. Na avaliação do desempenho do SRQ-20 foram estimados indicadores de validade (sensibilidade e especificidade). A curva Receiver Operator Characteristic Curve (ROC) foi utilizada para determinar o melhor ponto de corte para classificação de suspeitos/não suspeitos. O ponto de corte de melhor desempenho foi de 6/7 para a população investigada, revelando desempenho razoável com área sob a curva de 0,789. Os resultados indicam que o SRQ-20 possui característica discriminante regular.

scholarly journals Haemoconcentration as a predictor of severity in acute pancreatitis

2016 ◽  
Vol 4 (1) ◽  
pp. 3-7
Author(s):  
Tanka Prasad Bohara ◽  
Dimindra Karki ◽  
Anuj Parajuli ◽  
Shail Rupakheti ◽  
Mukund Raj Joshi
Keyword(s):  
Acute Pancreatitis ◽  
Pearson Correlation ◽  
Characteristic Curve ◽  
Scoring Systems ◽  
Cost Effective ◽  
Receiver Operator Characteristic Curve ◽  
First Episode ◽  
P Value ◽  
Receiver Operator Characteristic ◽  
Chi Square

Background: Acute pancreatitis is usually a mild and self-limiting disease. About 25 % of patients have severe episode with mortality up to 30%. Early identification of these patients has potential advantages of aggressive treatment at intensive care unit or transfer to higher centre. Several scoring systems are available to predict severity of acute pancreatitis but are cumbersome, take 24 to 48 hours and are dependent on tests that are not universally available. Haematocrit has been used as a predictor of severity of acute pancreatitis but some have doubted its role.Objectives: To study the significance of haematocrit in prediction of severity of acute pancreatitis.Methods: Patients admitted with first episode of acute pancreatitis from February 2014 to July 2014 were included. Haematocrit at admission and 24 hours of admission were compared with severity of acute pancreatitis. Mean, analysis of variance, chi square, pearson correlation and receiver operator characteristic curve were used for statistical analysis.Results: Thirty one patients were included in the study with 16 (51.61%) male and 15 (48.4%) female. Haematocrit at 24 hours of admission was higher in severe acute pancreatitis (P value 0.003). Both haematocrit at admission and at 24 hours had positive correlation with severity of acute pancreatitis (r: 0.387; P value 0.031 and r: 0.584; P value 0.001) respectively.Area under receiver operator characteristic curve for haematocrit at admission and 24 hours were 0.713 (P value 0.175, 95% CI 0.536 - 0.889) and 0.917 (P value 0.008, 95% CI 0.813 – 1.00) respectively.Conclusion: Haematocrit is a simple, cost effective and widely available test and can predict severity of acute pancreatitis.Journal of Kathmandu Medical College, Vol. 4(1) 2015, 3-7

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