Cytokine Production and Fatigue in Patients with Chronic Fatigue Syndrome and Healthy Control Subjects in Response to Exercise

1994 ◽  
Vol 18 (Supplement_1) ◽  
pp. S142-S146 ◽  
Author(s):  
Andrew Lloyd ◽  
Simon Gandevia ◽  
Alan Brockman ◽  
John Hales ◽  
Denis Wakefield
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Cytokine Production ◽  
Chronic Fatigue ◽  
Control Subjects ◽  
Fatigue Syndrome ◽  
Healthy Control ◽  
Response To Exercise

Clinical and Biochemical Characteristics Differentiating Chronic Fatigue Syndrome from Major Depression and Healthy Control Populations

2004 ◽  
Vol 12 (1) ◽  
pp. 5-35 ◽  
Author(s):  
Robert J. Suhadolnik ◽  
Daniel L. Peterson ◽  
Nancy L. Reichenbach ◽  
Gail Roen ◽  
Melodie Metzger ◽  
...  
Keyword(s):  
Major Depression ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Biochemical Characteristics ◽  
Fatigue Syndrome ◽  
Healthy Control

Neuropsychological deficits in patients with chronic fatigue syndrome

2004 ◽  
Vol 10 (2) ◽  
pp. 278-285 ◽  
Author(s):  
KIM BUSICHIO ◽  
LANA A. TIERSKY ◽  
JOHN DELUCA ◽  
BENJAMIN H. NATELSON
Keyword(s):  
Information Processing ◽  
Chronic Fatigue Syndrome ◽  
Executive Functioning ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Motor Speed ◽  
Neuropsychological Dysfunction ◽  
Speed Of Information Processing ◽  
Fatigue Syndrome ◽  
Healthy Control

The degree of neuropsychological dysfunction across multiple domains was examined in individuals suffering from chronic fatigue syndrome (CFS). In this descriptive study, a similar series of neuropsychological tests was administered to a group of CFS patients and healthy participants. More specifically, CFS patients (n = 141) who met the 1994 Case Definition criteria were compared to 76 healthy control participants on tests of memory, attention (concentration), speed of information processing, motor speed, and executive functioning. On the 18 measures administered, CFS patients scored 1 standard deviation below the healthy mean on nine measures and scored 2 standard deviations below the healthy mean on four of the measures. Moreover, results indicated that CFS patients were more likely than healthy controls to fail (1.6 SD below the healthy mean) at least one test in each of the following domains: attention, speed of information processing, and motor speed, but not on measures of memory and executive functioning. Finally, CFS patients demonstrated a greater total number of tests failed across domains. (JINS, 2004, 10, 278–285.)

Differences in Baseline Nasal Secretions Between Chronic Fatigue Syndrome (CFS) and Control Subjects

2002 ◽  
Vol 10 (1) ◽  
pp. 3-15 ◽  
Author(s):  
K. Naranch ◽  
S. M. Repka-Ramirez ◽  
Y.-J. Park ◽  
A. Velarde ◽  
R. Finnegan ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Control Subjects ◽  
Fatigue Syndrome ◽  
Nasal Secretions ◽  
And Control

scholarly journals Postural neurocognitive and neuronal activated cerebral blood flow deficits in young chronic fatigue syndrome patients with postural tachycardia syndrome

2012 ◽  
Vol 302 (5) ◽  
pp. H1185-H1194 ◽  
Author(s):  
Julian M. Stewart ◽  
Marvin S. Medow ◽  
Zachary R. Messer ◽  
Ila L. Baugham ◽  
Courtney Terilli ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Chronic Fatigue Syndrome ◽  
Neuronal Activity ◽  
Tilt Angle ◽  
Chronic Fatigue ◽  
Vasomotor Tone ◽  
N Value ◽  
Control Subjects ◽  
Fatigue Syndrome

Neurocognition is impaired in chronic fatigue syndrome (CFS). We propose that the impairment relates to postural cerebral hemodynamics. Twenty-five CFS subjects and twenty control subjects underwent incremental upright tilt at 0, 15, 30, 45, 60, and 75° with continuous measurement of arterial blood pressure and cerebral blood flow velocity (CBFV). We used an n-back task with n ranging from 0 to 4 (increased n = increased task difficulty) to test working memory and information processing. We measured n-back outcomes by the number of correct answers and by reaction time. We measured CBFV, critical closing pressure (CCP), and CBFV altered by neuronal activity (activated CBFV) during each n value and every tilt angle using transcranial Doppler ultrasound. N-back outcome in control subjects decreased with n valve but was independent of tilt angle. N-back outcome in CFS subjects decreased with n value but deteriorated as orthostasis progressed. Absolute mean CBFV was slightly less than in control subjects in CFS subject at each angle. Activated CBFV in control subjects was independent of tilt angle and increased with n value. In contrast, activated CBFV averaged 0 in CFS subjects, decreased with angle, and was less than in control subjects. CCP was increased in CFS subjects, suggesting increased vasomotor tone and decreased metabolic control of CBFV. CCP did not change with orthostasis in CFS subjects but decreased monotonically in control subjects, consistent with vasodilation as compensation for the orthostatic reduction of cerebral perfusion pressure. Increasing orthostatic stress impairs neurocognition in CFS subjects. CBFV activation, normally tightly linked to cognitive neuronal activity, is unrelated to cognitive performance in CFS subjects; the increased CCP and vasomotor tone may indicate an uncoupling of the neurovascular unit during orthostasis.

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