scholarly journals Using machine learning to ace cardiovascular risk tests

2020 ◽  
Vol 116 (14) ◽  
pp. 2173-2174
Author(s):  
James R Bell ◽  
Gemma A Figtree ◽  
Grant R Drummond
2021 ◽  
Author(s):  
Nawar Shara ◽  
Kelley M. Anderson ◽  
Noor Falah ◽  
Maryam F. Ahmad ◽  
Darya Tavazoei ◽  
...  

BACKGROUND Healthcare data are fragmenting as patients seek care from diverse sources. Consequently, patient care is negatively impacted by disparate health records. Machine learning (ML) offers a disruptive force in its ability to inform and improve patient care and outcomes [6]. However, the differences that exist in each individual’s health records, combined with the lack of health-data standards, in addition to systemic issues that render the data unreliable and that fail to create a single view of each patient, create challenges for ML. While these problems exist throughout healthcare, they are especially prevalent within maternal health, and exacerbate the maternal morbidity and mortality (MMM) crisis in the United States. OBJECTIVE Maternal patient records were extracted from the electronic health records (EHRs) of a large tertiary healthcare system and made into patient-specific, complete datasets through a systematic method so that a machine-learning-based (ML-based) risk-assessment algorithm could effectively identify maternal cardiovascular risk prior to evidence of diagnosis or intervention within the patient’s record. METHODS We outline the effort that was required to define the specifications of the computational systems, the dataset, and access to relevant systems, while ensuring data security, privacy laws, and policies were met. Data acquisition included the concatenation, anonymization, and normalization of health data across multiple EHRs in preparation for its use by a proprietary risk-stratification algorithm designed to establish patient-specific baselines to identify and establish cardiovascular risk based on deviations from the patient’s baselines to inform early interventions. RESULTS Patient records can be made actionable for the goal of effectively employing machine learning (ML), specifically to identify cardiovascular risk in pregnant patients. CONCLUSIONS Upon acquiring data, including the concatenation, anonymization, and normalization of said data across multiple EHRs, the use of a machine-learning-based (ML-based) tool can provide early identification of cardiovascular risk in pregnant patients. CLINICALTRIAL N/A


Rheumatology ◽  
2020 ◽  
Vol 59 (7) ◽  
pp. 1767-1769
Author(s):  
Luca Navarini ◽  
Michela Sperti ◽  
Damiano Currado ◽  
Luisa Costa ◽  
Marco A Deriu ◽  
...  

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Alexandros C. Dimopoulos ◽  
Mara Nikolaidou ◽  
Francisco Félix Caballero ◽  
Worrawat Engchuan ◽  
Albert Sanchez-Niubo ◽  
...  

2021 ◽  
Vol 8 ◽  
Author(s):  
Guan Wang ◽  
Yanbo Zhang ◽  
Sijin Li ◽  
Jun Zhang ◽  
Dongkui Jiang ◽  
...  

Objective: Preeclampsia affects 2–8% of women and doubles the risk of cardiovascular disease in women after preeclampsia. This study aimed to develop a model based on machine learning to predict postpartum cardiovascular risk in preeclamptic women.Methods: Collecting demographic characteristics and clinical serum markers associated with preeclampsia during pregnancy of 907 preeclamptic women retrospectively, we predicted the cardiovascular risk (ischemic heart disease, ischemic cerebrovascular disease, peripheral vascular disease, chronic kidney disease, metabolic system disease or arterial hypertension). The study samples were divided into training sets and test sets randomly in the ratio of 8:2. The prediction model was developed by 5 different machine learning algorithms, including Random Forest. 10-fold cross-validation was performed on the training set, and the performance of the model was evaluated on the test set.Results: Cardiovascular disease risk occurred in 186 (20.5%) of these women. By weighing area under the curve (AUC), the Random Forest algorithm presented the best performance (AUC = 0.711[95%CI: 0.697–0.726]) and was adopted in the feature selection and the establishment of the prediction model. The most important variables in Random Forest algorithm included the systolic blood pressure, Urea nitrogen, neutrophil count, glucose, and D-Dimer. Random Forest algorithm was well calibrated (Brier score = 0.133) in the test group, and obtained the highest net benefit in the decision curve analysis.Conclusion: Based on the general situation of patients and clinical variables, a new machine learning algorithm was developed and verified for the individualized prediction of cardiovascular risk in post-preeclamptic women.


Author(s):  
Jayasudha B S K ◽  
P N Sudha ◽  
Rachana S ◽  
Sahana. Anagha A Kashyap ◽  
Anusha L

Theranostics ◽  
2020 ◽  
Vol 10 (19) ◽  
pp. 8665-8676
Author(s):  
David de Gonzalo-Calvo ◽  
Pablo Martínez-Camblor ◽  
Christian Bär ◽  
Kevin Duarte ◽  
Nicolas Girerd ◽  
...  

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