scholarly journals P337. Anti-TNFalpha therapy is associated with rapid reduction of circulating monocyte numbers and blunted monocyte pro-inflammatory response in patients with Crohn’s disease

2016 ◽  
Vol 10 (suppl 1) ◽  
pp. S264-S265
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Response ◽  
Rapid Reduction

scholarly journals Post-operative pain after laparoscopic right hemicolectomy for Crohn’s disease: a case control study

2021 ◽  
Vol 84 (2) ◽  
pp. 271-274
Author(s):  
K McKevitt ◽  
S.M. Sahebally ◽  
S Patchett ◽  
A O’Toole ◽  
S Galvin ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Response ◽  
Right Hemicolectomy ◽  
Abdominal Abscess ◽  
Patient Gender ◽  
Pain Scores ◽  
Post Operative Pain ◽  
Equivalent Length ◽  
Laparoscopic Right Hemicolectomy

Aim: Surgery for Crohn’s disease (CD) is characterized by an enhanced inflammatory response. While inflammation can induce hyperalgesia, post-operative pain following surgery for CD has not been characterized. This retrospective study compared a consecutive series of patients undergoing laparoscopic right hemicolectomy for CD and neoplasia performed by a single surgeon. Method: Elective resections performed between Jan-2016 and Aug-2017 managed in an enhanced recovery pathway were eligible for inclusion. Patients were excluded if open surgery was performed, an ileostomy was fashioned, no patient-controlled analgesia (PCA) was used or data were incomplete. Results : 38 cases were included, 20 for neoplasia and 18 for ileocolonic CD. There was no difference in patient gender (P=0.520). CD patients were younger (39.8±2.8 Vs 77.2±2.1 years, P<0.001) but had an equivalent length of resection (312.9±43.5 Vs 283.3±71.7 mm, P=0.915). CD patients had higher pain scores on post-operative day 1 (6.8±0.8 Vs 2.6±1.0, P<0.001), day 2 (5.0±0.5 Vs 1.6±0.9, P<0.001) and day 3 (4.1±0.6 Vs 1.3±0.7, P=0.008). CD patients used their PCA for longer (85.7±16.3 Vs 47.7±4.2 hours, P=0.017) and used a greater total amount of morphine (148.6±33.8 Vs 37.0±7.8 mg, P<0.001). Post-operative CRP was higher in patients with CD on day 1 (P=0.011), day 2 (P=0.001), day 3 (P=0.001) and day 4 (P=0.007), but no leak or intra-abdominal abscess occurred in either group. Results: 38 cases were included, 20 for neoplasia and 18 for ileocolonic CD. There was no difference in patient gender (P=0.520). CD patients were younger (39.8±2.8 Vs 77.2±2.1 years, P<0.001) but had an equivalent length of resection (312.9±43.5 Vs 283.3±71.7 mm, P=0.915). CD patients had higher pain scores on post-operative day 1 (6.8±0.8 Vs 2.6±1.0, P<0.001), day 2 (5.0±0.5 Vs 1.6±0.9, P<0.001) and day 3 (4.1±0.6 Vs 1.3±0.7, P=0.008). CD patients used their PCA for longer (85.7±16.3 Vs 47.7±4.2 hours, P=0.017) and used a greater total amount of morphine (148.6±33.8 Vs 37.0±7.8 mg, P<0.001). Post-operative CRP was higher in patients with CD on day 1 (P=0.011), day 2 (P=0.001), day 3 (P=0.001) and day 4 (P=0.007), but no leak or intra-abdominal abscess occurred in either group. Conclusions: CD patients experience increased post-operative pain, require more post-operative analgesia and have an enhanced post-operative inflammatory response. Further studies to elucidate the mechanism of this hyperalgesia and strategies to obviate it are required.

scholarly journals Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

2013 ◽  
Vol 9 (1) ◽  
pp. e1003141 ◽  
Author(s):  
Nicolas Dreux ◽  
Jérémy Denizot ◽  
Margarita Martinez-Medina ◽  
Alexander Mellmann ◽  
Maria Billig ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Response ◽  
Point Mutations

Lactoferrin prevents invasion and inflammatory response following E. coli strain LF82 infection in experimental model of Crohn's disease

2014 ◽  
Vol 46 (6) ◽  
pp. 496-504 ◽  
Author(s):  
Lucia Bertuccini ◽  
Manuela Costanzo ◽  
Francesca Iosi ◽  
Antonella Tinari ◽  
Fabio Terruzzi ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Response ◽  
Experimental Model ◽  
Coli Strain ◽  
E Coli

scholarly journals Bacterial Translocation as Inflammatory Driver in Crohn’s Disease

2021 ◽  
Vol 9 ◽  
Author(s):  
Raquel Linares ◽  
Rubén Francés ◽  
Ana Gutiérrez ◽  
Oriol Juanola
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Response ◽  
Genetic Predisposition ◽  
Intestinal Barrier ◽  
Inflammatory Disorder ◽  
Bacterial Antigen ◽  
Increased Risk ◽  
Frequent Event ◽  
Bacterial Products

Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract responsible for intestinal lesions. The multifactorial etiology attributed to CD includes a combination of environmental and host susceptibility factors, which result in an impaired host–microbe gut interaction. Bacterial overgrowth and dysbiosis, increased intestinal barrier permeability, and altered inflammatory responses in patients with CD have been described in the past. Those events explain the pathogenesis of luminal translocation of bacteria or its products into the blood, a frequent event in CD, which, in turn, favors a sustained inflammatory response in these patients. In this review, we navigate through the interaction between bacterial antigen translocation, permeability of the intestinal barrier, immunologic response of the host, and genetic predisposition as a combined effect on the inflammatory response observed in CD. Several lines of evidence support that translocation of bacterial products leads to uncontrolled inflammation in CD patients, and as a matter of fact, the presence of gut bacterial genomic fragments at a systemic level constitutes a marker for increased risk of relapse among CD patients. Also, the significant percentage of CD patients who lose response to biologic therapies may be influenced by the translocation of bacterial products, which are well-known drivers of proinflammatory cytokine production by host immune cells. Further mechanistic studies evaluating cellular and humoral immune responses, gut microbiota alterations, and genetic predisposition will help clinicians to better control and personalize the management of CD patients in the future.

Clinical and inflammatory response to first ileocolic resection for Crohn’s disease

2016 ◽  
Vol 48 (4) ◽  
pp. 209-214
Author(s):  
Hanna Ribbing Wilén ◽  
Per-Olof Nyström ◽  
Leif Törkvist ◽  
Johannes Blom
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Response ◽  
Ileocolic Resection

scholarly journals P.1.01 A nationwide, longitudinal study of crohn’s disease among korean workers exposed to toluene

2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A77.2-A77
Author(s):  
Yeon-soon Ahn ◽  
Jin-Ha Yoon ◽  
Jeong-Ha Lee
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Response ◽  
Hippuric Acid ◽  
Technology Development ◽  
Reference Population ◽  
Development Project ◽  
Chemical Accident ◽  
Exposed Workers ◽  
High Level

The pathogenesis of inflammatory bowel diseases (IBD) probably involves an interaction between genetic and environmental factors. Recent studies have shown that air pollution and PFOA (perfluorooctanoic acid) are associated with IBD. It is presumed to be related to inflammatory response. Immunoreactivity and inflammatory response are known to be major important mechanisms that causes toluene induced toxicity. So we evaluated the Crohn’s disease morbidity among Korean workers exposed to toluene.MethodsData were collected from toluene-associated specialized medical check-up 2000 and 2004 in Korea. The number of workers admitted to hospital because of clinically diagnosed Crohn’s disease was analyzed in male workers exposed to toluene (n=149,183). As a control reference population, 2% of Korean men were randomly selected and their hospital admission data were analyzed. For toluene exposed workers, Standardized admission ratios (SARs) for Crohn’s disease, as determined by ICD-10 classifications, were estimated in reference to the control population.ResultsDuring follow up, 46 workers admitted because of Crohn’s diseases. Occupational exposure to toluene (5 63 852 person-years) was significantly associated with the SAR of Crohn’s disease (SAR: 1.60, 95% CI: 1.17–2.13), in particular, SARs of workers with 3rd quartile hippuric acid level was significantly increased (SAR: 1.95, 95% CI: 1.21–2.99).ConclusionIn conclusion, toluene-exposed workers exhibited significantly elevated SARs for Crohn’s disease, especially workers with high level of hippuric acid, compared to the age-matched reference population, suggesting a relatedness with toluene exposure. This work was supported by Korea Environmental Industry and Technology Institute (KEITI) through ‘The Chemical Accident Prevention Technology Development Project’ funded by Korea Ministry of Environment (MOE) (2017001970001).

scholarly journals P001 Succinate, a gut microbiota-derived metabolite, modulates the inflammatory status of the creeping fat in Crohn’s disease

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S123-S123
Author(s):  
C Serena ◽  
D Monfort-Ferre ◽  
M Bautista ◽  
M Menacho ◽  
M Martí ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Response ◽  
Intestinal Barrier ◽  
Fine Tuning ◽  
Clinical Activity ◽  
Faecal Calprotectin ◽  
Inflammatory Status ◽  
Adipose Tissue Dysfunction

Abstract Background Crohn’s disease [CD] is characterized by severe transmural inflammation with subsequent destruction of the intestinal barrier. Recent works suggest that bacterial infiltration across this leaky gut facilitates access to the mesenteric fat and the development of a subsequent inflammatory reaction in the surrounding adipose tissue named creeping fat [CF]. Dysbiosis in CD patients has been associated with an increase in succinate-producing bacteria and a decrease in succinate-consuming bacteria. In fact, elevated succinate levels have been found in the intestinal and faeces of CD patients. Succinate has been classically considered as a marker of hypoxia and tissue damage, assisting as a pro-inflammatory signal that triggers immune activation. However, recent observations support potential additional functions of succinate. We and others have shown that succinate plays a key role in fine-tuning of the inflammatory response, acting both as an alarmin and resolving molecule. Our hypothesis is that succinate, a microbiota-derived metabolite, is a new determinant of adipose tissue dysfunction in CD. Methods A well-characterized cohort was used to obtained mesenteric adipose tissue biopsies including a) 10 subjects with active CD that require surgery for their underlying pathology b) 10 subjects with inactive CD and c) 10 healthy controls undergoing surgery for non-acute process (herniorrhaphy, cholecystectomy for lithiasis, etc.). The groups were comparable in age, sex, and body mass index. We studied the effect of exogenous succinate in adipose tissue explants, adipose-stem cells (ASC), and adipose tissue macrophages (ATM) isolated from adipose tissue biopsies of CD patients with different clinical activity. Circulating succinate levels and inflammatory variables including hs-CRP and faecal calprotectin were also measured. Results We observed an increased expression of SUCNR1 in CF, including ASCs and ATMs, mainly in patients suffering from an active disease (figure 1A). Furthermore, succinate appears to elicit a different response in adipose tissue from CD patients, when activity status is considered. Thus, our results indicate that in an inflammatory local and systemic environment, such as occurs in CD active patients, succinate triggers a pro-inflammatory response in VAT depot, while when subjects are in a remission period, the response of VAT explants to succinate is similar to than the observed in healthy subjects, promoting an anti-inflammatory expression profile (Figure 1B). Interestingly, we found elevated circulating succinate levels in active CD patients but those decrease drastically in patients in remission of the disease (Figure 1C). Conclusion Succinate has a relevant role in adipose tissue dysfunction in CD.

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