scholarly journals P4167-Tesla Cardiac MRI with vector-ECG gating despite the magnetohydrodynamic effect in healthy volunteers

2019 ◽  
Vol 20 (Supplement_2) ◽  
Author(s):  
C Hamilton-Craig ◽  
D Staeb ◽  
K O"brien ◽  
G Galloway ◽  
M Barth
Keyword(s):  
Healthy Volunteers ◽  
Cardiac Mri ◽  
Ecg Gating ◽  
Magnetohydrodynamic Effect

scholarly journals 11637-Tesla Cardiac MRI for Ventricular and Valvular quantitation in healthy volunteers

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
C Hamilton-Craig ◽  
D Staeb ◽  
K O'Brien ◽  
G Galloway ◽  
M Barth
Keyword(s):  
Healthy Volunteers ◽  
Cardiac Mri

Evidence of occult right ventricular dysfunction in morbidly obese patients

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S.L.K Samuel Kulifay ◽  
D.S.L Dominic Lattanzio ◽  
B.M.M Brandon Mikolich ◽  
J.R.M Ronald Mikolich
Keyword(s):  
Ejection Fraction ◽  
Right Ventricular ◽  
Healthy Volunteers ◽  
Cardiac Mri ◽  
Pulse Sequences ◽  
Morbidly Obese ◽  
Study Cohort ◽  
Obese Patients ◽  
Ventricular Ejection Fraction ◽  
Strain Measurements

Abstract Background Abnormalities of right ventricular (RV) strain have been shown to occur prior to impairment of global right ventricular function, measured by global RV ejection fraction (RVEF) in patients with increased RV afterload, such as pulmonary hypertension. Obesity is a form of increased afterload involving both the right and left cardiac circulations, raising suspicion that impaired RV strain may be an early indicator of myocardial dysfunction. Purpose This study was designed to assess impairment of RV strain in obese patients with normal right ventricular ejection fraction (RVEF) using cardiac MRI Fast SENC (strain encoded) pulse sequences. Methods An institutional cardiac imaging database was queried for all patients with body mass index (BMI) greater than 35 kg/m2 who underwent measurement of RV global longitudinal strain (GLS), RV global circumferential strain (GCS) and 37 segmental strain measurements using cardiac MRI Fast-SENC pulse sequences. Global RVEF was computed for all patients using a standard cardiac MRI method using non-automated hand drawn RV endocardial borders. Global and regional strain measurements were compared to a cohort of healthy volunteers who also underwent CMR Fast-SENC imaging. Abnormal myocardial strain was defined as a value greater than −17%. Results Of the 356 patients in the database, 48 had a BMI greater than 35 kg/m2. Mean RV GLS and GCS for the study cohort were −16.6 and −15.8 respectively. For healthy volunteers RV GLS and GCS were −20.8 and −19.0 respectively. Comparison of mean RV GLS and GCS of both groups were statistically significant ANOVA p<0.001. The number of normal RV segmental strain values was significantly decreased in obese patients when compared to the normal cohort, ANOVA p<0.001 (Figure 1). Furthermore, the prevalence of abnormal RV GCS in morbidly obese patients with normal RVEF greater than or equal to 40% was 84% (21 of 25 patients). Conclusions These findings suggest that morbidly many obese patients have occult RV dysfunction despite a normal RVEF. This occult RV dysfunction not only affects RV global GLS and GCS, but also the percentage of normal segmental strain values. Detection of occult RV dysfunction is of clinical significance in that it may provide an opportunity for treatment before development of symptomatic right heart failure. Figure 1 Funding Acknowledgement Type of funding source: None

scholarly journals Comparison of treadmill exercise stress cardiac MRI to stress echocardiography in healthy volunteers for adequacy of left ventricular endocardial wall visualization: A pilot study

2013 ◽  
Vol 39 (5) ◽  
pp. 1146-1152 ◽  
Author(s):  
Paaladinesh Thavendiranathan ◽  
Jennifer A. Dickerson ◽  
Debbie Scandling ◽  
Vijay Balasubramanian ◽  
Michael L. Pennell ◽  
...  
Keyword(s):  
Pilot Study ◽  
Healthy Volunteers ◽  
Cardiac Mri ◽  
Stress Echocardiography ◽  
Treadmill Exercise ◽  
Left Ventricular ◽  
Exercise Stress

scholarly journals Left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
N Parashar ◽  
M Sinha ◽  
S Sharma ◽  
S Ramakrishnan
Keyword(s):  
Ejection Fraction ◽  
Healthy Volunteers ◽  
Cardiac Mri ◽  
Feature Tracking ◽  
Longitudinal Strain ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Radial Strain ◽  
Left Ventricular ◽  
Ventricular Cardiomyopathy ◽  
Lv Ejection Fraction

Abstract Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is not an isolated RV disease. Left ventricular (LV) or biventricular involvement is being increasingly diagnosed in such patients. There is available research to show that the LV peak strain calculated from feature tracking (FT) cardiac MRI is impaired even before the impairment of function. If present, such involvement is an adverse prognostic marker. Purpose The aim of this study is to calculate LV involvement in patients with ARVC using FT cardiac MRI. Methods 27 patients of ARVC who underwent cardiac MRI with late gadolinium enhancement (LGE) in our department were identified. 10 healthy volunteers (controls) were also assessed using non-contrast cardiac MRI. LV strain analysis was performed using Cvi42 Circle cardiovascular imaging software; and global LV peak radial, circumferential and longitudinal strain values were calculated. Patients were divided into two sub groups: those with preserved LV ejection fraction (LVEF) and those with reduced LVEF. Peak LV strain values were compared between the two groups of ARVC patients; and between ARVC patients with preserved LVEF and healthy volunteers. Results The LV peak global longitudinal strain (GLS), global circumferential strain (GCS) and global radial strain (GRS) were −17.7±2.47, −18.16±2.65, 31.04±6.07 respectively in healthy volunteers. LV global longitudinal (GLS), circumferential (GCS), and radial strain (GRS) were significantly impaired in ARVC/D patients (GLS: −11.97±4.34%, GCS: −14.35±4.32%, GRS: 22.1±7.39%). ARVC patients were divided into 2 subgroups: the preserved LV ejection fraction (LVEF) group (LVEF ≥55%, n=9) and the reduced LVEF group (LVEF <55%, n=18). In ARVC patients with reduced LVEF, the peak GLS was −9.99±3.94, GCS was −12.88±4.08 and GRS was 19.57±7.56. With preserved LVEF these values were −15.1±3.02, −17.3±3.3 and 27.1±3.67 respectively. In ARVC patients with preserved LVEF, the peak LV strain were impaired when compared with healthy volunteers with significant difference in peak GLS in between the two groups (p=0.05). Conclusion In patients with ARVC, cardiac MRI feature tracking can detect early LV dysfunction and thus adverse prognostic marker. Even in patients with normal LVEF, GLS was found to be significantly impaired as compared to healthy controls. Calculation of longitudinal strain Funding Acknowledgement Type of funding source: None

scholarly journals Performance of two Methods for Cardiac MRI Edema Mapping: Dual-Contrast Fast Spin-Echo and T2 Prepared Balanced Steady State Free Precession

2020 ◽  
Vol 192 (07) ◽  
pp. 669-677
Author(s):  
Patrick Krumm ◽  
Petros Martirosian ◽  
Dominik Rath ◽  
Meinrad Gawaz ◽  
Konstantin Nikolaou ◽  
...  
Keyword(s):  
Steady State ◽  
Healthy Volunteers ◽  
Cardiac Mri ◽  
Steady State Free Precession ◽  
Spin Echo ◽  
Myocardial Edema ◽  
Fast Spin Echo ◽  
Youden Index ◽  
Free Precession ◽  
Fast Spin

Purpose To compare true positive and false negative results of myocardial edema mapping in two methods. Myocardial edema may be difficult to detect on cardiac MRI. Materials and Methods 76 patients (age 59 ± 11 years, 15 female) with acute myocardial infarction (MI) and 10 healthy volunteers were prospectively included in this single-center study. 1.5 T cardiac MRI was performed in patients 2.5 days after revascularization (median) for edema mapping: Steady State Free Precession (SSFP) mapping sequence with T2-preparation pulses (T2prep); and dual-contrast Fast Spin-Echo (dcFSE) signal decay edema mapping. Late gadolinium enhancement (LGE) was used as the reference for expected edema in acute MI. Results 311 myocardial segments in patients were acutely infarcted with mean T2 73 ms for T2prep SSFP vs. 87 ms for dcFSE edema mapping. In healthy volunteers the mean T2 was 56 ms for T2prep SSFP vs. 50 ms for dcFSE edema mapping. Receiver operating characteristic (ROC) curve for T2prep SSFP show area under the curve (AUC) 0.962, p < 0.0001, Youden index J 0.8266, associated criterion > 60 ms, sensitivity 94 %, specificity 89 %. dcFSE ROC AUC 0.979, p < 0.0001, J 0.9219, associated criterion > 64 ms, sensitivity 93 %, specificity 99 %. Conclusion Both edema mapping methods indicate high-grade edema with high sensitivity. Nevertheless, edema in acute infarction may be focally underestimated in both mapping methods. Key Points:  Citation Format

scholarly journals 1129 Image-guided placement of ECG leads to improve ECG gating in cardiac MRI

2008 ◽  
Vol 10 (S1) ◽  
Author(s):  
James D Barnwell ◽  
Brian Hyslop ◽  
Larry Klein ◽  
Clif Stallings ◽  
Amanda Sturm
Keyword(s):  
Cardiac Mri ◽  
Ecg Gating ◽  
Image Guided ◽  
Ecg Leads

scholarly journals 7-Tesla Functional Cardiovascular MR Using Vectorcardiographic Triggering—Overcoming the Magnetohydrodynamic Effect

Tomography ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 323-332
Author(s):  
Christian Hamilton-Craig ◽  
Daniel Stäeb ◽  
Aiman Al Najjar ◽  
Kieran O'Brien ◽  
William Crawford ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Image Quality ◽  
Ejection Fraction ◽  
Healthy Volunteers ◽  
High Field ◽  
7 Tesla ◽  
Ultra High Field ◽  
Ventricular Ejection Fraction ◽  
Magnetohydrodynamic Effect ◽  
Cardiac Volumes

Objective: Ultra-high-field B0 ≥ 7 tesla (7T) cardiovascular magnetic resonance (CMR) offers increased resolution. However, electrocardiogram (ECG) gating is impacted by the magneto-hydrodynamic effect distorting the ECG trace. We explored the technical feasibility of a 7T magnetic resonance scanner using an ECG trigger learning algorithm to quantitatively assess cardiac volumes and vascular flow. Methods: 7T scans were performed on 10 healthy volunteers on a whole-body research MRI MR scanner (Siemens Healthineers, Erlangen, Germany) with 8 channel Tx/32 channels Rx cardiac coils (MRI Tools GmbH, Berlin, Germany). Vectorcardiogram ECG was performed using a learning phase outside of the magnetic field, with a trigger algorithm overcoming severe ECG signal distortions. Vectorcardiograms were quantitatively analyzed for false negative and false positive events. Cine CMR was performed after 3rd-order B0 shimming using a high-resolution breath-held ECG-retro-gated segmented spoiled gradient echo, and 2D phase contrast flow imaging. Artefacts were assessed using a semi-quantitative scale. Results: 7T CMR scans were acquired in all patients (100%) using the vectorcardiogram learning method. 3,142 R-waves were quantitatively analyzed, yielding sensitivity of 97.6% and specificity of 98.7%. Mean image quality score was 0.9, sufficient to quantitate both cardiac volumes, ejection fraction, and aortic and pulmonary blood flow. Mean left ventricular ejection fraction was 56.4%, right ventricular ejection fraction was 51.4%. Conclusion: Reliable cardiac ECG triggering is feasible in healthy volunteers at 7T utilizing a state-of-the-art three-lead trigger device despite signal distortion from the magnetohydrodynamic effect. This provides sufficient image quality for quantitative analysis. Other ultra-high-field imaging applications such as human brain functional MRI with physiologic noise correction may benefit from this method of ECG triggering.

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