scholarly journals Comparison of treadmill exercise stress cardiac MRI to stress echocardiography in healthy volunteers for adequacy of left ventricular endocardial wall visualization: A pilot study

2013 ◽  
Vol 39 (5) ◽  
pp. 1146-1152 ◽  
Author(s):  
Paaladinesh Thavendiranathan ◽  
Jennifer A. Dickerson ◽  
Debbie Scandling ◽  
Vijay Balasubramanian ◽  
Michael L. Pennell ◽  
...  
Keyword(s):  
Pilot Study ◽  
Healthy Volunteers ◽  
Cardiac Mri ◽  
Stress Echocardiography ◽  
Treadmill Exercise ◽  
Left Ventricular ◽  
Exercise Stress

Prognostic value of peak stress cardiac power in patients with normal ejection fraction undergoing exercise stress echocardiography

2020 ◽  
Author(s):  
Vidhu Anand ◽  
Garvan C Kane ◽  
Christopher G Scott ◽  
Sorin V Pislaru ◽  
Rosalyn O Adigun ◽  
...  
Keyword(s):  
Ejection Fraction ◽  
Stress Echocardiography ◽  
Stress Test ◽  
Peak Stress ◽  
Left Ventricular ◽  
Exercise Stress ◽  
Cardiac Power ◽  
Exercise Stress Echocardiography ◽  
Lv Mass

Abstract Aims  Cardiac power is a measure of cardiac performance that incorporates both pressure and flow components. Prior studies have shown that cardiac power predicts outcomes in patients with reduced left ventricular (LV) ejection fraction (EF). We sought to evaluate the prognostic significance of peak exercise cardiac power and power reserve in patients with normal EF. Methods and results  We performed a retrospective analysis in 24 885 patients (age 59 ± 13 years, 45% females) with EF ≥50% and no significant valve disease or right ventricular dysfunction, undergoing exercise stress echocardiography between 2004 and 2018. Cardiac power and power reserve (developed power with stress) were normalized to LV mass and expressed in W/100 g of LV myocardium. Endpoints at follow-up were all-cause mortality and diagnosis of heart failure (HF). Patients in the higher quartiles of power/mass (rest, peak stress, and power reserve) were younger and had higher peak blood pressure and heart rate, lower LV mass, and lower prevalence of comorbidities. During follow-up [median 3.9 (0.6–8.3) years], 929 patients died. After adjusting for age, sex, metabolic equivalents (METs) achieved, ischaemia/infarction on stress test results, medication, and comorbidities, peak stress power/mass was independently associated with mortality [adjusted hazard ratio (HR), highest vs. lowest quartile, 0.5, 95% confidence interval (CI) 0.4–0.6, P < 0.001] and HF at follow-up [adjusted HR, highest vs. lowest quartile, 0.4, 95% CI (0.3, 0.5), P < 0.001]. Power reserve showed similar results. Conclusion  The assessment of cardiac power during exercise stress echocardiography in patients with normal EF provides valuable prognostic information, in addition to stress test findings on inducible myocardial ischaemia and exercise capacity.

AB1140 ABNORMAL RIGHT VENTRICLE RESERVE FOLLOWING EXERCISE IN PATIENTS WITH CONNECTIVE TISSUE DISEASES

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1860.1-1860
Author(s):  
J. Zhang ◽  
T. Wu ◽  
R. Wu ◽  
J. Zhu
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Stress Echocardiography ◽  
Treadmill Exercise ◽  
Physiological Stress ◽  
Exercise Stress ◽  
Healthy Controls ◽  
Right Heart ◽  
Right Heart Dysfunction ◽  
Rv Function

Background:Recent studies have indicated that cardiac autonomic dysfunction is an early sign of cardiovascular impairment in patients with connective tissue disease (CTD). Previous studies have mainly focused on autonomic regulation during rest in this population. The cardiac autonomic responses to an acute physiological stress might provide additional information on the autonomic dysfunction, serving as a powerful predictor of cardiovascular disease and mortality in patients with CTD.Objectives:We aimed to use exercise stress echocardiography to detect early right heart dysfunction in patients with CTD and healthy controls.Methods:Treadmill exercise stress echocardiography was performed in 19 CTD patients (8 systemic sclerosis, 6 mixed CTD and 5 SLE) and 20 healthy volunteers. Parameters of right ventricular (RV) systolic function (RV fractional area change, Doppler tissue s’ velocity, and systolic strain and strain rate) and diastolic function (peak E and A velocity, Doppler tissue e’, a’ and early and late diastolic strain rate) were evaluated at baseline and after exercise, with the difference (Δ) being systolic and diastolic reserve. The immunoblotting assay was performed to detect the levels of rheumatoid factor (RF) and C-reactive protein (CRP) as well as autoantibodies such as, antinuclear antibody (ANA), anti-U1 ribonucleoproteins (U1RNP), anti-dsDNA, anti-Sm, anti-SSA, anti-SSB, anti-SCL-70 and RO-52. The correlation between these proteins and RV function was analyzed.Results:Both the patients with CTD and healthy controls had a normal range of BMI, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG). The average age of patients with CTD was 46.0 ± 10.4 years. At baseline, these patients presented no cardiovascular disease or pulmonary hypertension. No significant difference in the body weight, height, age, sex, blood pressure, RV and left ventricular (LV) function at rest between the two groups (allP>0.05). The parameters of RV systolic reserve decreased significantly in CTD group compared to those of the healthy controls (Δs’: 5.8±2.1 vs 8.3±2.5cm-1,P<0.01; ΔSr: 2.5±0.8 vs 2.8±0.7s-1,P<0.01). Consistently, RV diastolic reserve was significantly decreased in CTD patients compared to controls (Δe’: 2.8±1.5 vs 3.9±2.3cm-1,P<0.05; Δa’: 5.8±2.5 vs 10.9±6.3cm-1,P<0.05; ΔE-Sr: 0.8±0.2 vs 1.2±0.5s-1,P<0.05; ΔA-Sr: 0.9±0.3 vs 1.3±0.6s-1,P<0.05). To identify independent predictors of RV function in CTD patients, linear regression was conducted. This suggested that ANA, anti-U1RNP, anti-dsDNA, anti-Sm, anti-SSA, anti-SSB, anti-SCL-70 and RO-52 were not correlated with RV reserve (allP>0.05). A logistic regression analysis revealed that RF (P<0.05) and CRP (P<0.01) were independently associated with RV reserve in CTD patients in response to an acute physiological stress.Conclusion:Treadmill exercise echocardiography could detect right heart dysfunction early before diagnosed as cardiovascular diseases in patients with CTD. RV reserve after exercise might be a promising parameter to detect cardiovascular disease early in CTD patients.References:[1]Lazzerini PE, Capecchi PL, Laghi-Pasini F. Systemic inflammation and arrhythmic risk: lessons from rheumatoid arthritis.Eur Heart J. 2017;38(22):1717–1727.[2]Peçanha T, Rodrigues R, Pinto AJ, et al. Chronotropic Incompetence and Reduced Heart Rate Recovery in Rheumatoid Arthritis.J Clin Rheumatol. 2018;24(7):375–380.Disclosure of Interests:None declared

scholarly journals Cardiovascular risk profiles and stress echocardiography results in patients with hypertensive response to exercise

2021 ◽  
Vol 26 (5) ◽  
pp. 4183
Author(s):  
E. A. Karev ◽  
E. G. Malev ◽  
A. Yu. Suvorov ◽  
S. L. Verbilo ◽  
M. N. Prokudina
Keyword(s):  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Stress Echocardiography ◽  
Coronary Artery Stenosis ◽  
Left Ventricular ◽  
Artery Stenosis ◽  
Exercise Stress ◽  
Volume Index ◽  
High Cardiovascular Risk ◽  
Response To Exercise

Aim. To compare markers of high cardiovascular risk and stress echocardiography results depending on the type of blood pressure (BP) response to exercise in patients without obstructive coronary artery disease.Material and methods. Our single-center cross-sectional study included 96 patients without hemodynamically significant coronary artery stenosis according to coronary angiography or multislice computed tomography angiography. All patients underwent physical examination, cardiovascular risk stratification, electrocardiography, extracranial cerebrovascular ultrasound, echocardiography, treadmill exercise stress echocardiography.Results. According to the test results, the patients were divided into groups with a hypertensive response (n=41) and a normal response to exercise (n=55). Patients with hypertensive response to exercise had significantly higher values of left ventricular mass index (100,0 (90,0; 107,0) g/m2 vs 76,0 (68,0; 91,0) g/m2, p<0,0000001) and left atrial volume index (36,7 (32,0; 46,0) ml/m2 vs 29,7 (26,3; 32,0) ml/m2, p=0,000003). There was also a higher level of cardiovascular SCORE risk (5,0 (2,0; 6,0) vs 2,0 (1,0; 3,0), p=0,004); patients more often had associated clinical conditions (36,6% vs 12,7%, χ2=7,57, p=0,006) and left ventricular diastolic dysfunction (39,02% vs 78,18%, χ2=15,21, p=0,0001). Pathological BP increase during stress echocardiography was associated with worse exercise tolerance (7,4 (5,6; 10,0) METs vs 10,2 (8,4; 11,95) METs, p=0,000041) and more frequent transient regional contractility impairment (46,34% vs 1,8%, p<0,00001), mainly of the lateral and inferior left ventricular walls.Conclusion. Despite the absence of coronary artery stenosis, patients with hypertensive response to exercise are significantly more likely to have markers of high cardiovascular risk and require more careful monitoring of risk factors. Also, the hypertensive response to exercise is associated with more frequent regional contractility impairment even without coronary artery stenosis.

scholarly journals 1680 Left ventricular filling pressure assessment with exercise stress echocardiography in patients with non-valvular atrial fibrillation

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
K Lara-Breitinger ◽  
M W Ullah ◽  
C L Luong ◽  
R Padang ◽  
J K Oh ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Functional Capacity ◽  
Stress Echocardiography ◽  
Wall Motion ◽  
Regional Wall Motion ◽  
Left Ventricular ◽  
Filling Pressure ◽  
Exercise Stress ◽  
Regional Wall ◽  
Ventricular Filling

Abstract Background Noninvasive parameters of LV filling pressure (E/e’) and pulmonary pressures (RVSP) by Doppler echocardiography correlate with functional capacity and outcome in sinus rhythm (SR). Their role in AF is less clear. Elevated left ventricular filling pressures (E/e’) and pulmonary artery systolic pressures (PASP) by Doppler stress echocardiography correlate with impaired functional capacity in patients in sinus rhythm (SR). However, there is limited data in atrial fibrillation (AF). Purpose The aim of this study was to delineate the characteristics of patients with AF referred for exercise stress echocardiography and determine the prevalence and significance of E/e’ and PASP elevations in AF. Methods Subjects were patients referred for exercise treadmill stress echocardiography (n= 14,937) and underwent regional wall motion assessment, Doppler assessment of mitral inflow (E) and early tissue relaxation (e’) velocities and PASP at rest and immediately following maximum symptom limited exercise. Exclusion criteria included significant valvular heart disease (moderate or greater stenosis and/or regurgitation of any cardiac valve or previous valve repair or replacement) (1%), congenital heart disease (&lt;1%) or refusal to participate in research (&lt;1%). Results Patients with AF (n = 310, 2%) were older (71 ± 10 vs 59 ± 13 years, p &lt; 0.001). While resting blood pressure was similar, resting heart rates were higher in AF (80 ± 17 bpm vs 73 ± 13 bpm, p &lt; 0.0001). AF patients achieved lower workloads (6.4 ± 2.4 METS vs 9 ± 2.4 METS, p &lt; 0.001) with lower peak double products (22336 ± 6677 vs 25148 ± 5438, p &lt; 0.001). Rates of resting (27% vs 10%, p &lt; 0.0001) and exercise-induced (37% vs 20%, p &lt; 0.0001) regional wall motion abnormalities were higher in AF. Mean E/e’ was higher in AF at rest (12 ± 5 vs 9 ± 3, p &lt; 0.001) and with exercise (12 ± 5 vs 10 ± 4, p &lt; 0.001), with a higher percentage of patients in AF having E/e’ ≥15 at rest (20% vs 6% in SR, p= &lt;0.001) and with exercise in (23% vs 8%, p &lt; 0.001). PASP was higher in AF at rest (33 ± 8 mm Hg vs 28 ± 6 mm Hg, p &lt; 0.001) and with exercise (48 ± 12 vs 42 ± 11, p &lt; 0.001) compared to SR. E/e’ correlated with exercise capacity in AF and in SR, with an E/e’ cutoff of 11.7 that was best predictive of impaired functional capacity (&lt; 5 METS in women and &lt; 7 METS in men). Conclusions Abnormalities of E/e’ and PASP are more prevalent in patients with AF and correlate with impaired functional capacity. In patients with AF, a medial E/e’ ratio of ≥ 12 immediately following exercise is best associated with impaired functional capacity.

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