scholarly journals Linking observational and genetic approaches to determine the role of C-reactive protein in heart disease riskThe opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.

2006 ◽  
Vol 27 (11) ◽  
pp. 1261-1263 ◽  
Author(s):  
Aroon D. Hingorani ◽  
Tina Shah ◽  
Juan P. Casas
2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Frederik Strang ◽  
Heribert Schunkert

C-reactive protein (CRP) and coronary heart disease (CHD) have been the subject of intensive investigations over the last decades. Epidemiological studies have shown an association between moderately elevated CRP levels and incident CHD whereas genetic studies have shown that polymorphisms associated with elevated CRP levels do not increase the risk of ischemic vascular disease, suggesting that CRP might be a bystander rather than a causal factor in the progress of atherosclerosis. Beside all those epidemiological and genetic studies, the experimental investigations also try to reveal the role of CRP in the progress of atherosclerosis. This review will highlight the complex results of genomic, epidemiological, and experimental studies on CRP and will show why further studies investigating the relationship between CRP and atherosclerosis might be needed.


2020 ◽  
Vol 3 (1) ◽  
pp. 51-61
Author(s):  
Nadroh Br Sitepu ◽  
Urip Harahap

Coronary Heart Disease (CHD) is a disorder of the cardiovascular system, characterized by atherosclerotic lesions. Inflammation is a strong predictor for coronary heart disease. High sensitivity C-Reactive Protein (hs-CRP) is an important biomarker, synthesized in the liver, can predict the severity of CHD. If the hs-CRP level is found to be low 3 mg / L, a person has the potential for severe vascular risk. Therefore, hs-CRP can be used as a predictor of primary CHD prevention, especially if the hs-CRP level is still low.


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