scholarly journals Peak oxygen uptake and exercise capacity: a reliable predictor of quality of life?

2009 ◽  
Vol 30 (13) ◽  
pp. 1674-1674 ◽  
Author(s):  
S. Glaser ◽  
C. Schaper ◽  
R. Ewert ◽  
B. Koch
Keyword(s):  
Quality Of Life ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake ◽  
Reliable Predictor

scholarly journals Does allogeneic stem cell transplantation in survivors of pediatric leukemia impact regular physical activity, pulmonary function, and exercise capacity?

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Katharina Ruf ◽  
Alaa Badran ◽  
Céline Siauw ◽  
Imme Haubitz ◽  
Paul-Gerhardt Schlegel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Stem Cell ◽  
Oxygen Uptake ◽  
Stem Cell Transplantation ◽  
Pulmonary Function ◽  
Cell Transplantation ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake

Abstract Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved survival in high-risk childhood leukemia but is associated with long-term sequelae such as impaired pulmonary function and reduced exercise capacity impacting quality of life. Methods A convenience sample of 17 patients after allo-HSCT (HSCT—12 male, age 15.7±6.7 years, time after HSCT 5.3±2.8 years) underwent pulmonary function testing, echocardiography, and an incremental exercise test on a bike. Physical activity and health-related quality of life were assessed by questionnaires (7-day physical activity recall, PEDS-QL). Seventeen healthy age- and gender-matched controls served as control group (CG) for results of pulmonary function and exercise testing. Results HSCT showed reduced pulmonary function (HSCT vs. CG: FEV1 90.5±14.0 vs. 108.0±8.7%pred; FVC 88.4±19.3 vs. 107.6±6.9%pred, DLCO 75.3±23.6 vs. 104.9±12.8%pred) and exercise capacity (VO2peak 89±30.8%pred, CG 98±17.5%pred; Wmax 84±21.7%pred, CG 115±22.8%pred), but no relevant cardiac dysfunction and a good quality of life (PEDS-QL mean overall score 83.3±10.7). Differences in peak oxygen uptake between groups were mostly explained by 5 adolescent patients who underwent total body irradiation for conditioning. They showed significantly reduced diffusion capacity and reduced peak oxygen uptake. Patients reported a mean time of inactivity of 777±159min/day, moderate activity of 110±107 min/day, hard activity of 35±36 min/day, and very hard activity of 23±22 min/day. A higher amount of inactivity was associated with a lower peak oxygen uptake (correlation coefficient tau −0.48, p=0.023). Conclusions This pilot study shows that although patients after allo-HSCT reported a good quality of life, regular physical activity and exercise capacity are reduced in survivors of stem cell transplantation, especially in adolescents who are treated with total body irradiation for conditioning. Factors hindering regular physical activity need to be identified and exercise counseling should be part of follow-up visits in these patients.

scholarly journals Physical exercise training in patients with a Fontan circulation: A systematic review

2020 ◽  
pp. 204748732094286
Author(s):  
Linda E Scheffers ◽  
Linda EM vd Berg ◽  
Gamida Ismailova ◽  
Karolijn Dulfer ◽  
Johanna JM Takkenberg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Exercise Training ◽  
Oxygen Uptake ◽  
Cardiac Function ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake ◽  
Training Intervention ◽  
Fontan Patients

Background Patients with a Fontan circulation have a reduced exercise capacity, which is an important prognostic predictor of morbidity and mortality. A way to increase exercise capacity in Fontan patients might be exercise training. This systematic review assesses the effects of exercise training investigated in Fontan patients in order to provide an overview of current insights. Design and methods Studies evaluating an exercise training intervention in Fontan patients published up to February 2020 were included in this systematic review. Results From 3000 potential studies, 16 studies reported in 22 publications met the inclusion criteria. In total, 264 Fontan patients with mean age range 8.7–31 years, were included. Different training types including inspiratory muscle training, resistance training and aerobic training were investigated. Main outcome measures reported were peak oxygen uptake, cardiac function, lung function, physical activity levels and quality of life. Peak oxygen uptake increased significantly in 56% of the studies after training with an overall mean increase of +1.72 ml/kg/min (+6.3%). None of the studies reported negative outcome measures related to the exercise programme. In four studies an adverse event was reported, most likely unrelated to the training intervention. Conclusions Exercise training in Fontan patients is most likely safe and has positive effects on exercise capacity, cardiac function and quality of life. Therefore exercise training in Fontan patients should be encouraged. Further studies are required to assess the optimal training type, intensity, duration and long-term effects.

scholarly journals Determinants of Functional Capacity and Quality of Life After Implantation of a Durable Left Ventricular Assist Device

2020 ◽  
Vol 6 ◽  
Author(s):  
Kiran K Mirza ◽  
Finn Gustafsson
Keyword(s):  
Quality Of Life ◽  
Oxygen Uptake ◽  
Functional Capacity ◽  
Continuous Flow ◽  
Peak Oxygen Uptake ◽  
Left Ventricular ◽  
Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Left Ventricular Assist

Continuous-flow left ventricular assist devices (LVAD) are increasingly used as destination therapy in patients with end-stage heart failure and, with recent improvements in pump design, adverse event rates are decreasing. Implanted patients experience improved survival, quality of life (QoL) and functional capacity (FC). However, improvement in FC and QoL after implantation is not unequivocal, and this has implications for patient selection and preimplantation discussions with patients and relatives. This article identifies preimplantation predictors of lack of improvement in FC and QoL after continuous-flow LVAD implantation and discusses potential mechanisms, allowing for the identification of potential factors that can be modified. In particular, the pathophysiology behind insufficient improvement in peak oxygen uptake is discussed. Data are included from 40 studies, resulting in analysis of >700 exercise tests. Mean peak oxygen uptake was 13.4 ml/kg/min (equivalent to 48% of predicted value; 259 days after implantation, range 31–1,017 days) and mean 6-minute walk test distance was 370 m (182 days after implantation, range 43–543 days). Finally, the interplay between improvement in FC and QoL is discussed.

scholarly journals Analysis of exercise capacity, quality of life and leisure sports in patients with a Fontan circulation

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
A Niemann ◽  
K Rinne ◽  
A Uebing ◽  
I Voges
Keyword(s):  
Quality Of Life ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Fontan Circulation ◽  
Sports Activity ◽  
Large Group ◽  
Oxygen Pulse ◽  
Sporting Activity ◽  
Leisure Sports

Abstract Funding Acknowledgements Type of funding sources: None. Background/Introduction: Despite the improvement in survival, patients with a Fontan circulation are exposed to numerous complications as well as a reduced exercise capacity and quality of life.  Purpose To assess the influence of the type of single ventricle (right vs. left) and the amount of sporting activity on exercise capacity and health related quality of life (HRQol) in a large group of Fontan patients. Methods Retrospective analysis of standardised cardiopulmonary exercise tests (CPET) performed on a treadmill between 2014 and 2019. Questionnaires to measure HRQol and sporting activity were sent to study participants. Results 79 patients were enrolled in this study (female, n = 31). 56 of them had a systemic right ventricle (SRV), 20 had a systemic left ventricle (SLV) and 3 had diverse anatomies. Median age at CPET was 12.2 years (range 6.2-34.4 years). The results for important exercise parameters were as follows: peak oxygen uptake (VO2max) 30.7 ± 6.2 ml/kg/min, oxygen uptake at anaerobic threshold (VO2-VAT) 24.7 ± 5.8 ml/kg/min, peak oxygen pulse 8.2 ± 3.4 mlO2/beat and VE/VCO2 slope 39.8 ± 9.1. There was no significant difference in VO2max, VO2-VAT, peak oxygen pulse and VE/CO2 slope between SRV and SLV patients: VO2max 30.2 ± 5.6 vs. 32.8 ± 7.5 ml/kg/min, p = 0.14; VO2-AT 24.4 ± 5.3 vs.25.7 ± 7.3 ml/kg/min, p = 0.53; peak oxygen pulse 7.8 ± 3.2 vs. 9.5 ± 3.9 mlO2/beat, p = 0.06; VE/CO2 slope 41.1 ± 9.6 vs. 36.9 ± 6.8, p = 0.10. Analyses of the questionnaires revealed that most of the patients do leisure sports (n = 60, 76%) with nearly half of them more than two hours per week (n = 26, 33%). In a subgroup analysis of patients under 18 years (n = 51, 65%) we found that nearly all of them participate in school sports (n = 50) and have a good subjective healthiness (n = 47). VO2-VAT and VO2max correlated positively with subjective healthiness (VO2-VAT r = 0.32, p < 0.05; VO2max r = 0.35, p < 0.05) as well as with the amount of leisure sports activity (hours/week) (VO2-VAT r = 0.37, p < 0.01; VO2max r = 0.50, p < 0.01). Conclusions By analysing a large group of patients in Fontan circulation we could demonstrate that there is no difference in exercise capacity between SRV and SLV patients. Furthermore, most of the patients participate in leisure sports and have a good subjective healthiness. In a subgroup of paediatric patients, we were able to show that a better exercise capacity is associated with increased leisure sports activity and a better subjective healthiness.

scholarly journals Reduced peak oxygen uptake and implications for cardiovascular health and quality of life in patients with schizophrenia

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Jørn Heggelund ◽  
Jan Hoff ◽  
Jan Helgerud ◽  
Geir E Nilsberg ◽  
Gunnar Morken
Keyword(s):  
Quality Of Life ◽  
Oxygen Uptake ◽  
Cardiovascular Health ◽  
Peak Oxygen Uptake

scholarly journals Telemonitored exercise-based cardiac rehabilitation improves physical capacity and health-related quality of life

2018 ◽  
Vol 26 (1-2) ◽  
pp. 36-44 ◽  
Author(s):  
Sussie Laustsen ◽  
Lisa G Oestergaard ◽  
Maurits van Tulder ◽  
Vibeke E Hjortdal ◽  
Annemette K Petersen
Keyword(s):  
Quality Of Life ◽  
Oxygen Uptake ◽  
Cardiac Rehabilitation ◽  
Peak Oxygen Uptake ◽  
Physical Capacity ◽  
Muscle Endurance ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Introduction Cardiac rehabilitation improves physical capacity, health-related quality of life, and reduces morbidity and mortality among cardiac patients. Telemonitored exercise-based cardiac rehabilitation may innovate existing programmes and increase participation rates. Objective The purpose of this study was to investigate if telemonitored exercise-based cardiac rehabilitation improves physical capacity, muscle endurance, muscle power, muscle strength and health-related quality of life in cardiac patients. Methods A follow-up study on moderate risk patients with ischaemic heart and heart valve disease referred to a 12-week telemonitored exercise-based cardiac rehabilitation intervention at Aarhus University Hospital (Denmark). Participants were encouraged to exercise 60 min three times weekly with moderate/high intensity for 20 min per session. Intensity and duration of training sessions were visualised on a smartphone and uploaded to a website. Participants received individual feedback from physiotherapists on their training efforts by telephone/email. Outcome measures were changes in physical capacity (peak oxygen uptake), muscle endurance, power, and strength, and health-related quality of life between baseline end of telemonitored exercise-based cardiac rehabilitation intervention, and at six and 12 months after end of telemonitored exercise-based cardiac rehabilitation. Results Thirty-four participants completed telemonitored exercise-based cardiac rehabilitation. We identified a significant increase in peak oxygen uptake of 10%, in muscle endurance of 17%, in muscle power of 7%, and in muscle strength of 10% after the telemonitored exercise-based cardiac rehabilitation programme. Health-related quality of life was significantly improved by 19% in the physical and 17% in the mental component scores. We found no significant improvement in peak oxygen uptake between baseline and 12 months follow-up, but a significant improvement in muscle endurance (0.3 watts/kg, 95% confidence interval; 0.2–0.4), muscle power (0.4 watts/kg; 0.2–0.5), muscle strength (0.5 N/m/kg; 0.1–0.9), physical health-related quality of life (five points; 2–8) and mental health-related quality of life (six points; 3–9). Discussion This study demonstrated that the self-elected type of physical exercise in cardiac rehabilitation with telemonitoring improved all outcome measures both on the short and long-term, except for peak oxygen uptake at 12 months follow-up.

Controlled study of myocardial recovery after interval training in heart failure: SMARTEX-HF – rationale and design

2011 ◽  
Vol 19 (4) ◽  
pp. 813-821 ◽  
Author(s):  
Asbjørn Støylen ◽  
Viviane Conraads ◽  
Martin Halle ◽  
Axel Linke ◽  
Eva Prescott ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Exercise Training ◽  
Oxygen Uptake ◽  
Primary Endpoint ◽  
Interval Training ◽  
Peak Oxygen Uptake ◽  
Left Ventricular ◽  
Regular Exercise

Background: The large randomized controlled multicentre clinical trial, HF-ACTION, recently demonstrated that a programme of recommendation of regular exercise training at moderate intensity is safe, improves quality of life, and reduces the combined endpoint of all-cause death and hospitalization in patients with chronic heart failure. However, the size of beneficial effects was modest compared to results published in smaller single studies and meta-analyses. Objective: Based on results of a pilot study, the objective of the present investigation is to test the hypothesis that a programme comprising interval training at high relative intensity would yield significantly larger effects in terms of left ventricular remodelling compared to moderate continuous exercise training. Study design: In a three-armed randomized multicentre study of stable heart failure patients with left ventricular ejection fraction ≤35%, the effects of a 12-week programme of high-intensity interval training (HIT; 85–90% of peak oxygen uptake, VO2peak) will be compared to actual practice in Europe, represented by either an isocaloric programme of moderate continuous training (MCT; 50–60% of VO2peak) and a recommendation of regular exercise (RE) of the individual patients’ own preference based on clinical practice at the local centre. The primary endpoint is reverse remodelling, defined as change in left ventricular end-diastolic diameter assessed by echocardiography. Secondary endpoints include peak oxygen uptake (VO2peak), biomarkers, quality of life, and level of physical activity assessed by questionnaires. In addition, long-term maintenance of effects after the supervised training period will be determined. Assessments will be made at baseline, after the 12-week intervention programme, and at 1-year follow up. A total number of 200 patients on treatment per protocol, randomized to the three groups in a 1 : 1 : 1 manner, is estimated to detect clinically relevant differences in effect with HIT vs. MCT and RE ( p < 0.05; statistical power 0.90) for the primary endpoint. Inclusion of patients started May 2009 and will run until total number has been reached.

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