Functional High-Intensity Circuit Training Improves Body Composition, Peak Oxygen Uptake, Strength, and Alters Certain Dimensions of Quality of Life in Overweight Women

Abstract Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved survival in high-risk childhood leukemia but is associated with long-term sequelae such as impaired pulmonary function and reduced exercise capacity impacting quality of life. Methods A convenience sample of 17 patients after allo-HSCT (HSCT—12 male, age 15.7±6.7 years, time after HSCT 5.3±2.8 years) underwent pulmonary function testing, echocardiography, and an incremental exercise test on a bike. Physical activity and health-related quality of life were assessed by questionnaires (7-day physical activity recall, PEDS-QL). Seventeen healthy age- and gender-matched controls served as control group (CG) for results of pulmonary function and exercise testing. Results HSCT showed reduced pulmonary function (HSCT vs. CG: FEV1 90.5±14.0 vs. 108.0±8.7%pred; FVC 88.4±19.3 vs. 107.6±6.9%pred, DLCO 75.3±23.6 vs. 104.9±12.8%pred) and exercise capacity (VO2peak 89±30.8%pred, CG 98±17.5%pred; Wmax 84±21.7%pred, CG 115±22.8%pred), but no relevant cardiac dysfunction and a good quality of life (PEDS-QL mean overall score 83.3±10.7). Differences in peak oxygen uptake between groups were mostly explained by 5 adolescent patients who underwent total body irradiation for conditioning. They showed significantly reduced diffusion capacity and reduced peak oxygen uptake. Patients reported a mean time of inactivity of 777±159min/day, moderate activity of 110±107 min/day, hard activity of 35±36 min/day, and very hard activity of 23±22 min/day. A higher amount of inactivity was associated with a lower peak oxygen uptake (correlation coefficient tau −0.48, p=0.023). Conclusions This pilot study shows that although patients after allo-HSCT reported a good quality of life, regular physical activity and exercise capacity are reduced in survivors of stem cell transplantation, especially in adolescents who are treated with total body irradiation for conditioning. Factors hindering regular physical activity need to be identified and exercise counseling should be part of follow-up visits in these patients.

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Effects of a moderate-to-high intensity resistance circuit training on fat mass, functional capacity, muscular strength, and quality of life in elderly: A randomized controlled trial

Scientific Reports ◽

10.1038/s41598-019-44329-6 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 9

Author(s):

Pablo Jorge Marcos-Pardo ◽

Francisco Javier Orquin-Castrillón ◽

Gemma María Gea-García ◽

Ruperto Menayo-Antúnez ◽

Noelia González-Gálvez ◽

...

Keyword(s):

Quality Of Life ◽

Randomized Controlled Trial ◽

Fat Mass ◽

Functional Capacity ◽

High Intensity ◽

Muscular Strength ◽

Controlled Trial ◽

Circuit Training ◽

Randomized Controlled

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Physical exercise training in patients with a Fontan circulation: A systematic review

European Journal of Preventive Cardiology ◽

10.1177/2047487320942869 ◽

2020 ◽

pp. 204748732094286

Author(s):

Linda E Scheffers ◽

Linda EM vd Berg ◽

Gamida Ismailova ◽

Karolijn Dulfer ◽

Johanna JM Takkenberg ◽

...

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Exercise Training ◽

Oxygen Uptake ◽

Cardiac Function ◽

Exercise Capacity ◽

Peak Oxygen Uptake ◽

Training Intervention ◽

Fontan Patients

Background Patients with a Fontan circulation have a reduced exercise capacity, which is an important prognostic predictor of morbidity and mortality. A way to increase exercise capacity in Fontan patients might be exercise training. This systematic review assesses the effects of exercise training investigated in Fontan patients in order to provide an overview of current insights. Design and methods Studies evaluating an exercise training intervention in Fontan patients published up to February 2020 were included in this systematic review. Results From 3000 potential studies, 16 studies reported in 22 publications met the inclusion criteria. In total, 264 Fontan patients with mean age range 8.7–31 years, were included. Different training types including inspiratory muscle training, resistance training and aerobic training were investigated. Main outcome measures reported were peak oxygen uptake, cardiac function, lung function, physical activity levels and quality of life. Peak oxygen uptake increased significantly in 56% of the studies after training with an overall mean increase of +1.72 ml/kg/min (+6.3%). None of the studies reported negative outcome measures related to the exercise programme. In four studies an adverse event was reported, most likely unrelated to the training intervention. Conclusions Exercise training in Fontan patients is most likely safe and has positive effects on exercise capacity, cardiac function and quality of life. Therefore exercise training in Fontan patients should be encouraged. Further studies are required to assess the optimal training type, intensity, duration and long-term effects.

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Peak oxygen uptake and exercise capacity: a reliable predictor of quality of life?

European Heart Journal ◽

10.1093/eurheartj/ehp208 ◽

2009 ◽

Vol 30 (13) ◽

pp. 1674-1674 ◽

Cited By ~ 1

Author(s):

S. Glaser ◽

C. Schaper ◽

R. Ewert ◽

B. Koch

Keyword(s):

Quality Of Life ◽

Oxygen Uptake ◽

Exercise Capacity ◽

Peak Oxygen Uptake ◽

Reliable Predictor

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The impact of high intensity interval training on functional performance, body composition and quality of life in a diverse group of cancer survivors.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.12057 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. 12057-12057

Author(s):

Jennifer Lynn Beebe-Dimmer ◽

David Finlay ◽

Julie J. Ruterbusch ◽

Tara Baird ◽

Michael S. Simon ◽

...

Keyword(s):

Quality Of Life ◽

Body Composition ◽

Cancer Survivors ◽

High Intensity ◽

Functional Performance ◽

Interval Training ◽

High Intensity Interval Training ◽

High Intensity Interval ◽

The Impact

12057 Background: Given the well-documented benefits of regular exercise to cancer survivors, in 2012, an expert panel assembled by the American Cancer Society recommended that patients engage in at least 150 minutes per week of moderate-to-vigorous physical activity. However, few patients meet this goal. We have also observed racial differences in reported participation in regular exercise among cancer survivors living in Metropolitan Detroit, Michigan. Methods: The CAPABLE study is a 12- week pilot exercise intervention that introduces cancer survivors to the sport of CrossFit. We evaluated the impact of this unique, high-intensity interval training method on functional performance, cardiovascular endurance, body composition and health-related quality of life (HRQOL) as measured by the Functional Assessment of Cancer Therapy (FACT) instrument. All measures were summarized at baseline and program exit. Paired signed rank tests were used to assess change in each of these measures over time. Results: Of the 48 participants enrolled in the pilot, 37 (77%) were considered adherent to the program (attending at least 75% of sessions over the 12-week period). The mean age of participants was 58.5 years, 73% identified as African American and the majority of participants were breast cancer survivors (N = 20). The mean body mass index (BMI) at baseline was 32.8 kg/m2 decreasing to a mean of 31.7 kg/m2 at exit (BMI change -1.1, p < 0.001). Similar changes were observed in % body fat measured by bioelectrical impedance. There were significant improvements in all measures of functional performance over 12-weeks (all p < 0.001). We observed significant and meaningful improvements in reported HRQOL measured by the FACT survey, overall (FACTG total change +9.5 (p < 0.001)) and in each one of the individual domains (physical, social, emotional, and functional well-being). Conclusions: We observed significant improvements in performance, body composition and quality of life among cancer survivors introduced to a high-intensity interval training program. Understanding and eliminating barriers to programs like these are critical to improving outcomes and reducing cancer health disparities. Clinical trial information: NCT03750981 .

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The Effect of High-Intensity Interval/Circuit Training on Cognitive Functioning and Quality of Life During Recovery From Substance Abuse Disorder. A Study Protocol

Frontiers in Psychology ◽

10.3389/fpsyg.2019.02564 ◽

2019 ◽

Vol 10 ◽

Cited By ~ 1

Author(s):

Øyvind Andreassen ◽

Kolbjørn Brønnick ◽

Anne-Lill Njå ◽

Einar Furulund ◽

Sverre Nesvåg

Keyword(s):

Quality Of Life ◽

Substance Abuse ◽

Cognitive Functioning ◽

Study Protocol ◽

High Intensity ◽

Substance Abuse Disorder ◽

Circuit Training ◽

High Intensity Interval

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Determinants of Functional Capacity and Quality of Life After Implantation of a Durable Left Ventricular Assist Device

Cardiac Failure Review ◽

10.15420/cfr.2020.15 ◽

2020 ◽

Vol 6 ◽

Author(s):

Kiran K Mirza ◽

Finn Gustafsson

Keyword(s):

Quality Of Life ◽

Oxygen Uptake ◽

Functional Capacity ◽

Continuous Flow ◽

Peak Oxygen Uptake ◽

Left Ventricular ◽

Ventricular Assist Devices ◽

Ventricular Assist ◽

Left Ventricular Assist

Continuous-flow left ventricular assist devices (LVAD) are increasingly used as destination therapy in patients with end-stage heart failure and, with recent improvements in pump design, adverse event rates are decreasing. Implanted patients experience improved survival, quality of life (QoL) and functional capacity (FC). However, improvement in FC and QoL after implantation is not unequivocal, and this has implications for patient selection and preimplantation discussions with patients and relatives. This article identifies preimplantation predictors of lack of improvement in FC and QoL after continuous-flow LVAD implantation and discusses potential mechanisms, allowing for the identification of potential factors that can be modified. In particular, the pathophysiology behind insufficient improvement in peak oxygen uptake is discussed. Data are included from 40 studies, resulting in analysis of >700 exercise tests. Mean peak oxygen uptake was 13.4 ml/kg/min (equivalent to 48% of predicted value; 259 days after implantation, range 31–1,017 days) and mean 6-minute walk test distance was 370 m (182 days after implantation, range 43–543 days). Finally, the interplay between improvement in FC and QoL is discussed.

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