scholarly journals TLR2 and neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion

2015 ◽  
Vol 36 (22) ◽  
pp. 1394-1404 ◽  
Author(s):  
Thibaut Quillard ◽  
Haniel Alves Araújo ◽  
Gregory Franck ◽  
Eugenia Shvartz ◽  
Galina Sukhova ◽  
...  
2019 ◽  
Vol 8 (3) ◽  
pp. 940
Author(s):  
Tatar Sumandjar ◽  
Bambang Purwanto ◽  
Brian Wasita ◽  
Dono Indarto ◽  
Risya Cilmiaty ◽  
...  

1976 ◽  
Vol 51 (3) ◽  
pp. 23P-23P
Author(s):  
George Drivas ◽  
Nigel Wardle

2005 ◽  
Vol 19 (8) ◽  
pp. 1042-1044 ◽  
Author(s):  
Hyo‐Soo Kim ◽  
Carsten Skurk ◽  
Henrike Maatz ◽  
Ichiro Shiojima ◽  
Yuri Ivashchenko ◽  
...  

2003 ◽  
Vol 1642 (3) ◽  
pp. 173-179 ◽  
Author(s):  
Sofia I.M. Carlsson ◽  
Maria T.S. Bertilaccio ◽  
Erica Ballabio ◽  
Jeanette A.M. Maier

2018 ◽  
Vol 275 ◽  
pp. e11 ◽  
Author(s):  
G. Franck ◽  
T. Mawson ◽  
E. Folco ◽  
R. Molinaro ◽  
V. Ruvkun ◽  
...  

2019 ◽  
Vol 12 (5) ◽  
pp. 1980
Author(s):  
Salem Leandro Moura dos Santos ◽  
Eliomar Pereira da Silva Filho ◽  
Isabel Leonor Iza Echeverria Herrera

Este estudo tem o objetivo de estabelecer o nível piezométrico que a vertente tinha antes do deslizamento, a morfometria e a causa do movimento de massa. Para isto, foi utilizada equação de Equilíbrio-Limite, com o Fator de segurança em 1,49 para estabelecer o nível piezométrico necessário para causar o colapso da encosta, como também, a determinação de propriedades geomecânicas, como coesão, densidade, ângulo de atrito, tensão de cisalhamento, limites de Atterberg, além da granulometria e da morfometria. A vertente apresentava o formato convexo no topo e côncavo na base, ambos seccionados no meio pelos formatos retilíneo e côncavo. A inclinação média era de 35,17° em uma dimensão de 46,01m. A Equação indicou um nível piezométrico mínimo de 18,53 metros de altura para o colapso. Um aspecto que influenciou o deslizamento foi à erosão superficial causada por uma galeria de água pluvial, que uma vez rompida, erodiu o pacote de material superficial, Argilo Siltoso Mosqueado, que serve de proteção para a vertente, pois possui maior coesão e plasticidade. Após a completa erosão do pacote superior, houve a exposição pontual do pacote inferior, que após sofrer forte precipitação pluvial de 32,20 mm, ocorrida no dia 30/09/2013, ocasionou a elevação do nível piezométrico deste material inferior, Silto Arenoso Tangencial, de menor coesão e plasticidade que saturou, comportando-se de maneira semi-líquida. Devido este material ser todo o alicerce da encosta, o seu colapso causou todo o deslizamento rotacional da vertente. Verifica-se a importância de manter o material superior desta margem do Rio  Landslide in The Madeira River Slope in Porto Velho - RO: A Morfomechanical analysis ABSTRACTThe aims this paper is establish the piezometric level that the slope had before sliding, morphometry and the cause of mass movement. For this, the Equilibrium-Limit equation was used, with the Safety Factor at 1.49 to establish the piezometric level necessary for collapse of the slope, as well as the determination of geomechanical properties, such as cohesion, density, friction angle , shear stress, Atterberg boundaries, granulometry and morphometry. The strand had the convex shape at the top and concave at the base, both sectioned in the middle by the rectilinear and concave shapes. The average slope was 35.17° in a dimension of 46.01m. Equation indicated a minimum piezometric level of18.53 metershigh for collapse. One aspect that influenced the sliding was the superficial erosion caused by a gallery of rainwater, which once ruptured, eroded the package of surface material, Silt Clay Mottled, which serves as protection for the slope, as it has greater cohesion and plasticity. After complete erosion of the upper package, there was a punctual exposition of the lower package, which after suffering heavy rainfall of32.20 mm, occurred on 09/30/2013, caused the elevation of the piezometric level of this lower material, Sand Silt Tangential, of lower cohesion and plasticity that saturated, behaving in a semi-liquid way. Because this material is the whole foundation of the slope, its collapse caused all the rotational slip of the slope. It’s important to maintain the superior material of the slope, aiming at the reduction of shear forces and erosions.Keywords: Piezometric Level, morphometry, Break Circle.


2013 ◽  
pp. 14-9
Author(s):  
Wiwit Nurwidyaningtyas ◽  
Djanggan Sargowo ◽  
Achdiat Agoes ◽  
Titin Andri W ◽  
S Satuman

Research background. Circulating Endothelial Cells (CEC) is a reflection of endothelial damage or endothelial stress, increasing of CEC amount depend on endothelial mechanism, edothelial adhesivity damage and cellular apoptosis as a result of decreasing sitoskleleton function. If higher exposure affects the increasing of CEC amount,VEGF other growth factor mediators will be reflected as endothelial stress manifestation which roles in the increasing of re-population and Endothelial Progenitor Cells (EPC) differentiation. Endothelial Progenitor Cells is a mononuclear cell (a part of stem cell) that could change to be mature endothel and roles in re-edothelialisation and neovascularisation. This research aimed to investigate the ratio of EPC : CEC in risk group through Framingham Risk Score (FRS) 10 years approach as endothelial dysfunction predictor.Research method and result. There were 55 research subjects whom taken by FRS scoring and devided into some risk groups and two control groups. They were control group I (health) and control group II (sick). Base blood was taken to every each of them to analyze their EPC and CEC with Flowcytometry. EPC was analyzed by CD34 Per CP Santa Cruz SC-19621 and CD 133 FITC (fluorescein isothiocyanate) Bioss bs-0395R-FITCmarker.WhileCEC was analyzed CD45 FITC Biolegend 202205 dan CD 146 PE Biolegend 134704 marker. Result showed, there was significant ratio differences of EPC : CEC in those six groups which was proven by p-value 0.032< ? (0.05). The higher ratio was in high risk group (139.06).Conclusion. Research showed that EPC amount was increase related to the increasing of high risk level according to FRS 10 years, but its increasing did not followed by its ability to homing in injury area as role part in re-endothelialisation process. It found that EPC amount was higher in high risk group than in low risk group.


Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Roberto Molinaro ◽  
Rob S Sellar ◽  
Grasiele Sausen ◽  
Amelie Vromman ◽  
Eduardo Folco ◽  
...  

Introduction: In the current era of intense LDL lowering, superficial erosion may be on the rise as a cause of ACS (25-30%). Experimental data on human atheromata support a role for neutrophils and the formation of neutrophil extracellular traps (NETs) in the pathogenesis of superficial erosion and subsequent thrombosis. The common mutation of Janus kinase 2 ( Jak2 V617F ) borne by clones of leukocytes derived from bone marrow stem cells sensitizes neutrophils to undergo NETosis and linked NET formation to increased thrombosis. Jak2 V617F associates with accelerated atherosclerosis and venous thrombosis in patients with myeloproliferative neoplasms (MPN) and in individuals harboring this mutation but without a demonstrable MPN. Hypothesis We hypothesized that i) the Jak2 V617F associated with clonal hematopoiesis and increased atherosclerotic and thrombotic risk in humans, predisposes to NETosis and subsequent endothelial injury and thrombosis at sites of flow disturbance in arteries with erosion-like intimas; and ii) the clinically approved Jak-1,2 inhibitor, ruxolitinib (Rux), can preserve endothelial integrity and reduce thrombosis in mice with myeloid Jak2 V617F . Methods: We generated cohorts of mice harboring Jak2 V617F or wild-type Jak2 . We used a surgical preparation recapitulating features of superficial erosion and assessed endothelial integrity, thrombosis, and NET formation in relation to genotype and in vivo Rux treatment. Results and Conclusions: Evans blue extravasation following introduction of flow disturbance at sites of erosion-prone intimas showed significant impairment of endothelial barrier in the group of mice bearing the Jak2 V617F mutation compared to control (WT) mice ( ** p<0.005). We further observed more thrombosis in mice bearing the Jak2 V617F mutation. Immunohistochemical evaluation of the regions of experimental superficial erosion revealed reduced endothelial continuity and increased NET accumulation in Jak2 V617F vs. WT mice. Rux treatment mitigated the adverse effects of Jak2 V617F on both NET accumulation and endothelial integrity, supporting the translational potential of these observations in individuals with clonal hematopoiesis due to Jak2 V617F and acute coronary syndromes.


2012 ◽  
Vol 160 (3) ◽  
pp. 351-358 ◽  
Author(s):  
Rachel Rosovsky ◽  
Fangxin Hong ◽  
Deanna Tocco ◽  
Brendan Connell ◽  
Constantine Mitsiades ◽  
...  

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