scholarly journals Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index

2019 ◽  
Vol 40 (34) ◽  
pp. 2849-2855 ◽  
Author(s):  
Guo-Chong Chen ◽  
Rhonda Arthur ◽  
Neil M Iyengar ◽  
Victor Kamensky ◽  
Xiaonan Xue ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Body Fat ◽  
Normal Body Mass Index ◽  
Cvd Risk ◽  
Normal Body ◽  
Increased Risk ◽  
Regional Body Fat

Abstract Aims Central adiposity is associated with increased cardiovascular disease (CVD) risk, even among people with normal body mass index (BMI). We tested the hypothesis that regional body fat deposits (trunk or leg fat) are associated with altered risk of CVD among postmenopausal women with normal BMI. Methods and results We included 2683 postmenopausal women with normal BMI (18.5 to <25 kg/m2) who participated in the Women’s Health Initiative and had no known CVD at baseline. Body composition was determined by dual energy X-ray absorptiometry. Incident CVD events including coronary heart disease and stroke were ascertained through February 2017. During a median 17.9 years of follow-up, 291 incident CVD cases occurred. After adjustment for demographic, lifestyle, and clinical risk factors, neither whole-body fat mass nor fat percentage was associated with CVD risk. Higher percent trunk fat was associated with increased risk of CVD [highest vs. lowest quartile hazard ratio (HR) = 1.91, 95% confidence interval (CI) 1.33–2.74; P-trend <0.001], whereas higher percent leg fat was associated with decreased risk of CVD (highest vs. lowest quartile HR = 0.62, 95% CI 0.43–0.89; P-trend = 0.008). The association for trunk fat was attenuated yet remained significant after further adjustment for waist circumference or waist-to-hip ratio. Higher percent trunk fat combined with lower percent leg fat was associated with particularly high risk of CVD (HR comparing extreme groups = 3.33, 95% CI 1.46–7.62). Conclusion Among postmenopausal women with normal BMI, both elevated trunk fat and reduced leg fat are associated with increased risk of CVD.

scholarly journals Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index

JAMA Oncology ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. 155 ◽  
Author(s):  
Neil M. Iyengar ◽  
Rhonda Arthur ◽  
JoAnn E. Manson ◽  
Rowan T. Chlebowski ◽  
Candyce H. Kroenke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Body Fat ◽  
Normal Body Mass Index ◽  
Normal Body

scholarly journals Neck circumference as an independent predictor for NAFLD among postmenopausal women with normal body mass index

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Jie Shi ◽  
Zixuan Wang ◽  
Weiwei Zhang ◽  
Yixin Niu ◽  
Ning Lin ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Neck Circumference ◽  
Normal Body Mass Index ◽  
Model Assessment ◽  
Cross Sectional ◽  
Normal Body ◽  
Increased Risk ◽  
Large Neck

Abstract Background Neck circumference, a proxy for upper-body subcutaneous fat, is a unique and pathogenic fat depot that confers additional metabolic risk. The purpose of present study was to determine whether neck circumference associates with nonalcoholic fatty liver disease (NAFLD) in postmenopausal women with normal body mass index. Methods A cross-sectional survey (n = 2492) and a 3.1-year follow-up investigation (n = 1354) were conducted among Chinese postmenopausal women with normal BMI (18.5 to < 25 kg/m2). Neck circumference was measured horizontally at the lower margin of the laryngeal prominence. Results In the cross-sectional analysis, large neck circumference was associated with the presence of NAFLD (odds ratio 2.28; 95% CI 1.74–2.98; highest tertile versus lowest tertile) after adjustment for confounding factors. Among 1354 subjects without the NAFLD at baseline, 429 (31.7%) incident NAFLD cases occurred at 3.1 years. Neck circumference was positively associated with triglycerides, homeostasis model assessment of insulin resistance, C-reactive protein, and negatively associated with high-density lipoprotein cholesterol and adiponectin. Individuals with large baseline neck circumference had a significantly higher risk of NAFLD than those with small neck circumference. The multivariable adjusted hazard ratio was 1.42 (95% CI 1.15–1.97; p for trend = 0.004) for the highest versus the lowest tertile of neck circumference, and was 1.22 (95% CI 1.10–1.41; p = 0.006) per 1-standard deviation increment in neck circumference. Conclusions Among postmenopausal women with normal BMI, relatively large neck circumference levels are associated with an increased risk of NAFLD.

scholarly journals Neck circumference as an independent predictor for NAFLD among postmenopausal women with normal body mass index

2021 ◽  
Author(s):  
Jie Shi ◽  
Zixuan Wang ◽  
Weiwei Zhang ◽  
Yixin Niu ◽  
Ning Lin ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Neck Circumference ◽  
Normal Body Mass Index ◽  
Model Assessment ◽  
Cross Sectional ◽  
Normal Body ◽  
Increased Risk ◽  
Large Neck

Abstract Background: Neck circumference, a proxy for upper-body subcutaneous fat, is a unique and pathogenic fat depot that confers additional metabolic risk. The purpose of present study was to determine whether neck circumference associates with nonalcoholic fatty liver disease (NAFLD) in postmenopausal women with normal body mass index.Methods: A cross-sectional survey (n=2,492) and a 3.1-year follow-up investigation (n=1,354) were conducted among Chinese postmenopausal women with normal BMI (18.5 to <25 kg/m2). Neck circumference was measured horizontally at the lower margin of the laryngeal prominence.Results: In the cross-sectional analysis, large neck circumference was associated with the presence of NAFLD (odds ratio 2.28; 95% CI 1.74-2.98; highest tertile versus lowest tertile) after adjustment for confounding factors. Among 1,354 subjects without the NAFLD at baseline, 429 (31.7 %) incident NAFLD cases occurred at 3.1 years. Neck circumference was positively associated with triglycerides, homeostasis model assessment of insulin resistance, C-reactive protein, and negatively associated with high-density lipoprotein cholesterol and adiponectin. Individuals with large baseline neck circumference had a significantly higher risk of NAFLD than those with small neck circumference. The multivariable adjusted hazard ratio was 1.42 (95% CI 1.15-1.97; p for trend =0.004) for the highest versus the lowest tertile of neck circumference, and was 1.22 (95% CI 1.10-1.41; p =0.006) per 1-standard deviation increment in neck circumference.Conclusions: Among postmenopausal women with normal BMI, relatively large neck circumference levels are associated with an increased risk of NAFLD.

scholarly journals Neck circumference as an independent predictor for NAFLD among postmenopausal women with normal body mass index

2020 ◽  
Author(s):  
Jie Shi ◽  
Zixuan Wang ◽  
Weiwei Zhang ◽  
Yixin Niu ◽  
Ning Lin ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Neck Circumference ◽  
Normal Body Mass Index ◽  
Model Assessment ◽  
Cross Sectional ◽  
Normal Body ◽  
Increased Risk ◽  
Large Neck

Abstract Background Neck circumference, a proxy for upper-body subcutaneous fat, is a unique and pathogenic fat depot that confers additional metabolic risk. The purpose of present study was to determine whether neck circumference associates with nonalcoholic fatty liver disease (NAFLD) in postmenopausal women with normal body mass index. Methods A cross-sectional survey (n = 2492) and a 3.1-year follow-up investigation (n = 1354) were conducted among Chinese postmenopausal women with normal BMI (18.5 to < 25 kg/m2). Neck circumference was measured horizontally at the lower margin of the laryngeal prominence. Results In the cross-sectional analysis, large neck circumference was associated with the presence of NAFLD (odds ratio 2.28; 95% CI 1.74–2.98; highest tertile versus lowest tertile) after adjustment for confounding factors. Among 1,354 subjects without the NAFLD at baseline, 429 (31.7%) incident NAFLD cases occurred at 3.1 years. Neck circumference was positively associated with triglycerides, homeostasis model assessment of insulin resistance, C-reactive protein, and negatively associated with high-density lipoprotein cholesterol and adiponectin. Individuals with large baseline neck circumference had a significantly higher risk of NAFLD than those with small neck circumference. The multivariable adjusted hazard ratio was 1.42 (95% CI 1.15–1.97; p for trend = 0.004) for the highest versus the lowest tertile of neck circumference, and was 1.22 (95% CI 1.10–1.41; p = 0.006) per 1-standard deviation increment in neck circumference. Conclusions Among postmenopausal women with normal BMI, relatively large neck circumference levels are associated with an increased risk of NAFLD.

Abstract P172: Associations of Body Mass Index From Early-, Mid-, and Older- Adulthood With Incident Heart Failure and Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Michael J Fliotsos ◽  
Di Zhao ◽  
Chiadi Ndumele ◽  
Eliseo Guallar ◽  
Gregory L Burke ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Older Adults ◽  
Body Mass Index ◽  
Body Mass ◽  
Clinical Encounter ◽  
Cvd Risk ◽  
Prognostic Information ◽  
Measured Weight ◽  
Increased Risk

Background: Obesity contributes significantly to increased risk of cardiovascular disease (CVD) and particularly heart failure (HF). However, an elevated body mass index (BMI) in older adults might not fully reflect the additional risk associated with excess weight at a younger age. We determined the prognostic value of self-reported weights from early- and mid-adulthood, after accounting for current weight, with incident HF and CVD. Methods: We studied 6,437 MESA participants (aged 45-84 years) with self-reported weights at ages 20 and 40 (by questionnaire) and measured weight at the baseline exam (2000-2002). BMI was calculated using measured height at baseline. Cox hazard models assessed relationships between BMI at each age with HF and CVD. Results: Participant mean age was 62±10 years and 53% were women. Over a median follow-up of 13 years, 290 HF and 828 CVD events occurred. Elevated BMI at each age point (age 20, age 40, and MESA baseline) was independently associated with HF, and to lesser extent with CVD ( Figure ). After adjustment for demographics, CVD risk factors, and baseline BMI, higher self-reported BMIs at ages 20 and 40 years were independently associated with increased risk of incident HF with hazard ratios (HR) 1.18 (95% CI 1.05-1.32) and 1.30 (1.15-1.46), respectively, per 1 SD higher BMI. Participants with self-reported obesity (BMI≥30) at age 20 [HR 3.20 (1.93-5.32)] and age 40 [HR 1.92 (1.31-2.83)] had greater HF risk, even after accounting for current BMI. For incident CVD, only higher self-reported BMI at age 20 (per 1 SD) was associated after accounting for current BMI [HR 1.09 (1.01-1.17)]. Conclusions: Assessment of self-reported lifetime weights is a simple tool utilized in any clinical encounter. Although subject to recall bias, self-reported weights provide prognostic information about future HF risk, incremental to current BMI, in a multi-ethnic cohort of middle-aged to older adults.

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