P623Regional Longitudinal Strain for Prediction of Left Ventricular Thrombus Formation following Acute Myocardial Infarction

Background Left ventricular thrombus (LVT) formation is a dangerous complication to acute myocardial infarction (MI). Purpose We hypothesized that regional strain impairment was predictive of LVT formation. Methods We included 373 prospectively enrolled patients with ST-segment elevation MI treated with primary percutaneous intervention. All patients had an echocardiogram performed a median of 2 days post-MI. Using logistic regression, we investigated the predictive value of left ventricular (LV) speckle tracking, conventional echocardiographic measures and well-known echocardiographic features of LVT formation including LV smoke, aneurysm and valvular regurgitations. Results Overall, the mean age was 62 years, 75% were male, 5% had prior MI, and 48% had anterior infarcts. Mean LVEF was 46% and absolute global longitudinal strain (GLS) was 12%. Of 373 patients, 31 (8%) developed LVT in follow-up echocardiograms. Patients with LVT more frequently had anterior infarcts, prior MI, lower LVEF, lower e', lower GLS and regional strain, and these were all univariable predictors of LVT formation. In multivariable analysis (including anterior infarcts, prior MI, LVEF, e'), GLS and regional strain remained independent predictors of LVT formation (GLS: OR: 1.17 [1.00; 1.36], midventricular strain: OR: 1.19 [1.03; 1.38], apical strain: 1.12 [1.00; 1.25], p<0.05 for all) (figure) In a combined diagnostic model, including anterior infarct, impaired LVEF (<42%) and apical strain (<8%), the sensitivity and negative predictive value was 100%, with a specificity and positive predictive value of 38 and 13%, respectively. Regional strain and risk of LVT Conclusion In MI patients, anterior infarct, LVEF and apical strain were strong predictors of LVT formation. Reduced apical strain indicates a markedly increased LVT risk.