A Glucose Transporter Chimera Confers a Dominant Negative Glucose Starvation Phenotype in Saccharomyces cerevisiae
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Abstract A family of glucose transporters mediates glucose uptake in Saccharomyces cerevisiae. We show that the dominant mutation GSF4-1, which impairs glucose repression of SUC2, results in a nonfunctional chimera of the transporters Hxt1p and Hxt4p. Hxt1/4p inhibits the function of wild-type glucose transporters. Similar mutations may facilitate analysis of the major facilitator superfamily.
2002 ◽
Vol 292
(3)
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pp. 741-748
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2002 ◽
Vol 277
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pp. 49841-49849
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2001 ◽
Vol 45
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pp. 1528-1534
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1990 ◽
Vol 10
(3)
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pp. 1105-1115
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