scholarly journals Frailty Changes Predict Mortality in 4 Longitudinal Studies of Aging

2020 ◽  
Author(s):  
Erwin Stolz ◽  
Emiel O Hoogendijk ◽  
Hannes Mayerl ◽  
Wolfgang Freidl
Keyword(s):  
Mortality Risk ◽  
Clinical Decision Making ◽  
Frailty Index ◽  
Credible Interval ◽  
Clinical Decision ◽  
Population Based ◽  
Time To Event Data ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study

Abstract Background Baseline frailty index (FI) values have been shown to predict mortality among older adults, but little is known about the effects of changes in FI on mortality. Methods In a coordinated approach, we analyzed data from 4 population-based cohorts: the Health and Retirement Study (HRS), the Survey of Health, Ageing and Retirement in Europe (SHARE), the English Longitudinal Survey of Ageing (ELSA), and the Longitudinal Aging Study Amsterdam (LASA), comprising a total of 24 961 respondents (65+), 95 897 observations, up to 9 repeated FI assessments, and up to 23 years of mortality follow-up. The effect of time-varying FI on mortality was modeled with joint regression models for longitudinal and time-to-event data. Results Differences (of 0.01) in current FI levels (hazard ratio [HR] = 1.04, 95% credible interval [CI] = 1.03–1.05) and baseline FI levels (HR = 1.03, 95% CI = 1.03–1.05) were consistently associated with mortality across studies. Importantly, individuals with steeper FI growth also had a higher mortality risk: An increase in annual FI growth by 0.01 was associated with an increased mortality risk of HR = 1.56 (95% CI = 1.49–1.63) in HRS, HR = 1.24 (95% CI = 1.13–1.35) in SHARE, HR = 1.40 (95% CI = 1.25–1.52) in ELSA, and HR = 1.71 (95% CI = 1.46–2.01) in LASA. Conclusions FI changes predicted mortality independently of baseline FI differences. Repeated assessment of frailty and individual’s frailty trajectory could provide a means to anticipate further health deterioration and mortality and could thus support clinical decision making.

scholarly journals Trends in Frailty and its Association with Mortality: Results From the Longitudinal Aging Study Amsterdam (1995-2016)

2021 ◽  
Author(s):  
Emiel O Hoogendijk ◽  
Erwin Stolz ◽  
Richard C Oude Voshaar ◽  
Dorly J H Deeg ◽  
Martijn Huisman ◽  
...  
Keyword(s):  
Older Adults ◽  
Frailty Index ◽  
Estimating Equation ◽  
Significant Interaction Effect ◽  
Policy Makers ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study ◽  
Stable Association ◽  
Age Range

Abstract The aim of the current study was to investigate trends in frailty and its relationship with mortality among older adults aged 64-84 years across a period of 21 years. Data from 1995 to 2016 were used from the Longitudinal Aging Study Amsterdam. A total of 7,742 observations of 2,874 respondents in the same age range (64-84 years) across six measurement waves were included. Frailty was measured with a 32-item frailty index, with a cut-point of ≥0.25 to indicate frailty. The outcome measure was 4-year mortality. Generalized Estimating Equation analyses showed that among older adults aged 64-84 years the 4-year mortality rate declined between 1995 and 2016, while the prevalence of frailty increased. Across all measurement waves, frailty was associated with 4-year mortality (Odds Ratio: 2.79, 95% Confidence Interval: 2.39, 3.26). There was no statistically significant interaction effect between frailty and time on 4-year mortality, indicating a stable association between frailty and mortality. In more recent generations of older adults, frailty prevalence rates were higher, while excess mortality rates of frailty remained the same. This is important information for health policy makers and clinical practice, as it shows that continued efforts are needed to reduce frailty and its negative health consequences.

scholarly journals Development and validation of a frailty index in the Longitudinal Aging Study Amsterdam

2016 ◽  
Vol 29 (5) ◽  
pp. 927-933 ◽  
Author(s):  
Emiel O. Hoogendijk ◽  
Olga Theou ◽  
Kenneth Rockwood ◽  
Bregje D. Onwuteaka-Philipsen ◽  
Dorly J. H. Deeg ◽  
...  
Keyword(s):  
Frailty Index ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study ◽  
Development And Validation

scholarly journals Thyroid function and the metabolic syndrome in older persons: a population-based study

2013 ◽  
Vol 168 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Nathalie E Heima ◽  
E Marelise W Eekhoff ◽  
Mirjam M Oosterwerff ◽  
Paul T A Lips ◽  
Natasja M van Schoor ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Representative Sample ◽  
Older Persons ◽  
Population Based ◽  
Population Based Study ◽  
The Metabolic Syndrome ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study ◽  
Serum Tsh

BackgroundStudies suggest an association between a high TSH and (individual components of) the metabolic syndrome. Only a few studies have been performed in the general older population.ObjectiveThis study investigates the association between serum TSH and the metabolic syndrome in a representative sample of older persons in The Netherlands.Design and patientsData of the Longitudinal Aging Study Amsterdam were used, which is an ongoing cohort study in a representative sample of Dutch older persons. A total of 1187 subjects (590 men and 597 women) between the ages of 65 and 88 years participated in the study.MeasurementsMetabolic syndrome (US National Cholesterol Education Program definition) and its individual components were assessed, as well as serum TSH levels.ResultsAmong the participants, the prevalence of the metabolic syndrome was 34.2%. The mean serum TSH was 1.9 mU/l. Subjects in the upper quartile with a serum TSH level above 2.28 mU/l (odds ratio (OR)=1.68; 95% confidence interval (CI) 1.19–2.37) had a significantly increased prevalence of metabolic syndrome compared with subjects in the lowest quartile with a serum TSH below 1.04 mU/l. After adjustment for confounders, age, sex, alcohol use, total physical activity, and smoking, the OR was 1.62 (95% CI 1.15–2.32).ConclusionsSubjects with a serum TSH in the upper quartile have a higher prevalence of metabolic syndrome as compared with subjects with a serum TSH in the lowest quartile.

Gender differences in the relation between depression and social support in later life

2012 ◽  
Vol 25 (1) ◽  
pp. 61-70 ◽  
Author(s):  
C.M. Sonnenberg ◽  
D.J.H. Deeg ◽  
T.G. van Tilburg ◽  
D. Vink ◽  
M.L. Stek ◽  
...  
Keyword(s):  
Social Support ◽  
Gender Differences ◽  
Later Life ◽  
Population Based ◽  
Late Life Depression ◽  
Need For Affiliation ◽  
Prevalence Of Depression ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study

ABSTRACTBackground: Prevalence of depression is twice as high in women as in men, also in older adults. Lack of social support is a risk factor for late-life depression. The relation between depression and social support may be different for men and women.Methods: Data from the Longitudinal Aging Study Amsterdam were used to investigate gender differences in the relation between social support and depression in a population-based sample aged 55–85 years, with n = 2,823 at baseline and using the 13-year follow-up data on onset of depression.Results: Respondents without a partner in the household, with a small network, and with low emotional support were more often depressed, with men showing higher rates of depression than women. A high need for affiliation was associated with depression in women but not in men. Lack of a partner in the household and having a small network predicted onset of depression in men but not in women. In respondents with high affiliation need and low social support, depression rates were higher, with men being more often depressed than women.Conclusions: Low social support and a high need for affiliation were related to depression in later life, with men being more vulnerable for depression than women. Considering the serious consequences of depression, especially in older people, it is important to identify the persons with low social support and a high need for affiliation, and to help them to increase their social support or to adjust their needs.

scholarly journals Inequalities in Frailty Among Older Turkish and Moroccan Immigrants and Native Dutch: Data from the Longitudinal Aging Study Amsterdam

2021 ◽  
Author(s):  
Emiel O. Hoogendijk ◽  
Maaike E. Muntinga ◽  
Sascha de Breij ◽  
Martijn Huisman ◽  
Silvia S. Klokgieters
Keyword(s):  
Educational Level ◽  
Frailty Index ◽  
Country Of Origin ◽  
Deficit Accumulation ◽  
Cross Sectional ◽  
Turkish Immigrants ◽  
Older Immigrants ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study

AbstractVery few studies have investigated frailty among older immigrants in Europe. The aim of the current study was to investigate inequalities in frailty in young-olds related to gender, educational level and country of origin, as well as intersections between these characteristics. Cross-sectional data were used from older Turkish and Moroccan immigrants (n = 466) and native Dutch (n = 1,020), all aged 55–65 years and participating in the Longitudinal Aging Study Amsterdam. Frailty was assessed with a 30-item frailty index, based on the deficit accumulation approach. Frailty was higher among women, lower educated, and people with a migration background. Of all groups considered, frailty levels were the highest among Turkish immigrants. No statistically significant interaction effects between gender, educational level and country of origin were found. When targeting frailty interventions, special attention should be devoted to older immigrants, as they are the most vulnerable group with the highest frailty levels.

scholarly journals Older adults report cancellation or avoidance of medical care during the COVID-19 pandemic: results from the Longitudinal Aging Study Amsterdam

2021 ◽  
Author(s):  
Noah A. Schuster ◽  
Sascha de Breij ◽  
Laura A. Schaap ◽  
Natasja M. van Schoor ◽  
Mike J. L. Peters ◽  
...  
Keyword(s):  
Older Adults ◽  
Primary Care ◽  
Medical Care ◽  
Help Seeking ◽  
Community Dwelling ◽  
Multiple Chronic Conditions ◽  
Hospital Outpatient ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study

Abstract Purpose Delay of routine medical care during the COVID-19 pandemic may have serious consequences for the health and functioning of older adults. The aim of this study was to investigate whether older adults reported cancellation or avoidance of medical care during the first months of the COVID-19 pandemic, and to explore associations with health and socio-demographic characteristics. Methods Cross-sectional data of 880 older adults aged ≥ 62 years (mean age 73.4 years, 50.3% female) were used from the COVID-19 questionnaire of the Longitudinal Aging Study Amsterdam, a cohort study among community-dwelling older adults in the Netherlands. Cancellation and avoidance of care were assessed by self-report, and covered questions on cancellation of primary care (general practitioner), cancellation of hospital outpatient care, and postponed help-seeking. Respondent characteristics included age, sex, educational level, loneliness, depression, anxiety, frailty, multimorbidity and information on quarantine. Results 35% of the sample reported cancellations due to the COVID-19 situation, either initiated by the respondent (12%) or by healthcare professionals (29%). Postponed help-seeking was reported by 8% of the sample. Multimorbidity was associated with healthcare-initiated cancellations (primary care OR = 1.92, 95% CI = 1.09–3.50; hospital OR = 1.86, 95% CI = 1.28–2.74) and respondent-initiated hospital outpatient cancellations (OR = 2.02, 95% CI = 1.04–4.12). Depressive symptoms were associated with postponed help-seeking (OR = 1.15, 95% CI = 1.06–1.24). Conclusion About one third of the study sample reported cancellation or avoidance of medical care during the first months of the pandemic, and this was more common among those with multiple chronic conditions. How this impacts outcomes in the long term should be investigated in future research.

scholarly journals Predictors in starting and stopping Internet use between 2002 and 2012 by Dutch adults 65 years and older

2017 ◽  
Vol 25 (3) ◽  
pp. 715-730 ◽  
Author(s):  
Jessica Berner ◽  
Marja Aartsen ◽  
Dorly Deeg
Keyword(s):  
Older Adults ◽  
Psychological Health ◽  
Internet Use ◽  
Cox Regression ◽  
Demographic Predictors ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study ◽  
Normal Cognition ◽  
High Sense

Research has indicated the need to consider the ageing process with technology adoption by older adults. This study examined psychological, health, social and demographic predictors with starting and stopping Internet use by older adults (2002–2012). Data were used from the Longitudinal Aging Study Amsterdam, and Cox regression analyses were done to test predictors over time with starting or stopping Internet use. The results indicated that older adults starting to use the Internet (11.6%) outnumbered those who stopped (3.1%). Psychological, health, social and demographic predictors separately predicted starting and stopping Internet use. Starting use was predicted by lower age, higher education, normal cognition and living alone. The predictors in stopping use were being younger, having a high sense of mastery and being higher educated. The results need to be interpreted as indicative due to the small number of stoppers. Suggestions are made on how to improve usability.

scholarly journals Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals

2011 ◽  
Vol 165 (4) ◽  
pp. 545-554 ◽  
Author(s):  
Renate T de Jongh ◽  
Paul Lips ◽  
Natasja M van Schoor ◽  
Kelly J Rijs ◽  
Dorly J H Deeg ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Subclinical Hypothyroidism ◽  
Population Based ◽  
Thyroid Disorders ◽  
Older Individuals ◽  
Cross Sectional ◽  
Thyroid Medication ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Subclinical Thyroid Disorders

ObjectiveTo what extent endogenous subclinical thyroid disorders contribute to impaired physical and cognitive function, depression, and mortality in older individuals remains a matter of debate.DesignA population-based, prospective cohort of the Longitudinal Aging Study Amsterdam.MethodsTSH and, if necessary, thyroxine and triiodothyronine levels were measured in individuals aged 65 years or older. Participants were classified according to clinical categories of thyroid function. Participants with overt thyroid disease or use of thyroid medication were excluded, leaving 1219 participants for analyses. Outcome measures were physical and cognitive function, depressive symptoms (cross-sectional), and mortality (longitudinal)ResultsSixty-four (5.3%) individuals had subclinical hypothyroidism and 34 (2.8%) individuals had subclinical hyperthyroidism. Compared with euthyroidism (n=1121), subclinical hypo-, and hyper-thyroidism were not significantly associated with impairment of physical or cognitive function, or depression. On the contrary, participants with subclinical hypothyroidism did less often report more than one activity limitation (odds ratio 0.44, 95% confidence interval (CI) 0.22–0.86). After a median follow-up of 10.7 years, 601 participants were deceased. Subclinical hypo- and hyper-thyroidism were not associated with increased overall mortality risk (hazard ratio 0.89, 95% CI 0.59–1.35 and 0.69, 95% CI 0.40–1.20 respectively).ConclusionsThis study does not support disadvantageous effects of subclinical thyroid disorders on physical or cognitive function, depression, or mortality in an older population.

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