Residential Street Block Disorder and Biological Markers of Aging in Older Adults: The National Health and Aging Trends Study

2021 ◽  
Author(s):  
Laken C Roberts Lavigne ◽  
Jing Tian ◽  
Melissa Hladek ◽  
Sarah E LaFave ◽  
Sarah L Szanton ◽  
...  
Keyword(s):  
Older Adults ◽  
Propensity Score ◽  
National Health ◽  
Interleukin 6 ◽  
Hemoglobin A1c ◽  
Community Dwelling ◽  
Neighborhood Environment ◽  
Adult Health ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract Background Residential environments are associated with older adult health, but underlying physiologic causal mechanisms are not well understood. As adults age, street blocks are likely more relevant to their health than the larger neighborhood environment. This study examined the effects of adverse street block conditions on aging biomarkers among older adults. Methods We included community-dwelling Medicare beneficiaries aged 67 and older with 2017 biomarker data from the nationally representative National Health and Aging Trends Study (n=4,357). Street block disorder in 2016 was measured using interviewer report of any trash/glass/litter, graffiti, or vacant buildings on participants’ blocks. Propensity score models were used to create balanced groups with regard to multiple 2015 participant characteristics, including demographic, socioeconomic, residence, and early life characteristics. Linear regressions modeled street block disorder as a predictor of four aging biomarkers, hemoglobin A1C, high-sensitivity C-reactive protein, interleukin-6, and cytomegalovirus antibodies, before and after applying propensity score weighting. Results Adjusting for participant sociodemographic characteristics and applying propensity score weights, living on a block with any disorder was associated with 2% higher mean hemoglobin A1C levels (95% CI: 0.002-0.03), 13% higher C-reactive protein (95% CI: 0.03-0.23), 10% higher interleukin-6 (95% CI: 0.02-0.19), and 19% more cytomegalovirus antibodies (95% CI: 0.09-0.29) compared to living on a block with no disorder. Conclusions Street block disorder predicted subsequent aging biomarkers after applying a propensity score approach to account for confounding among a national sample of older adults. Targeting street-level residential contexts for intervention may reduce risk for poor health in older adults.

Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study

2020 ◽  
Author(s):  
Wan-Hsuan Lu ◽  
Philipe de Souto Barreto ◽  
Yves Rolland ◽  
Ali Bouyahia ◽  
Clara Fischer ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Hippocampal Volume ◽  
Community Dwelling ◽  
Low Grade ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Hydroxyvitamin D ◽  
Reactive Protein ◽  
25 Hydroxyvitamin D

Abstract Background This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years. Methods We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers (Apolipoprotein E genotypes, amyloid-β deposits), and neuroimaging data (gray matter volume, hippocampal volume, white matter hyperintensities) were compared between groups. Cox proportional hazard model was used to evaluate the associations between biomarkers and incident frailty. Results A total of 195 participants (14.0%) became frail over 5 years. Although 25-hydroxyvitamin D deficiency, homocysteine levels, low-grade inflammation (persistently increased C-reactive protein 3–10 mg/L), gray matter, and hippocampal volume were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the sole marker that presented a trend of association with incident frailty (hazard ratio: 0.92; 95% confidence interval: 0.83–1.01; p = .082). Conclusions This study failed to identify biomarkers able to predict frailty incidence in community-dwelling older adults for a period of 5 years. Further longitudinal research with multiple measurements of biomarkers and frailty is needed to evaluate the long-term relationships between changes in biomarkers levels and frailty evolution.

scholarly journals Association between inflammatory mediators, grip strength and mobility in community-dwelling elderly

2018 ◽  
Vol 31 (0) ◽  
Author(s):  
Barbara Gazolla de Macedo ◽  
Hanna Sette Câmara de Oliveira ◽  
Marielle Viotti de Paula ◽  
Gisele de Cássia Gomes ◽  
Carlos Maurício de Figueiredo Antunes
Keyword(s):  
Grip Strength ◽  
Muscle Mass ◽  
Functional Capacity ◽  
Inflammatory Mediators ◽  
Interleukin 6 ◽  
The Elderly ◽  
Community Dwelling ◽  
Elderly Subjects ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract Introduction: Aging is associated with loss of muscle mass, immunosenescence and increased production of inflammatory mediators, high levels being predictors of a decline in functional capacity in the elderly. Objective: To assess the association between inflammatory mediators, interleukin 6 (IL-6) and C-reactive protein (CRP) and functional capacity in the elderly. Methods: Cross-sectional study with 308 community-dwelling elderly. The study was approved by the Research Ethics Committee, under protocol number 067/2010. Grip strength (GS) was measured using a JAMAR® dynamometer and functional capacity by the Timed Up and Go (TUG) test. Blood tests were performed and serum levels of C-reactive protein and interleukin 6 assessed. Spearman’s coefficient was applied to analyze the correlation between variables and the Mann-Whitney for intergroup comparison. Significance was set at 0.05. Results: There was no significant correlation between GS, the TUG and inflammatory mediators (CRP and IL-6). However, by adjusting for variables such as age, sex and muscle mass, a significant and inverse correlation (p = 0.023) was observed between GS and CPR. Conclusion: Elderly subjects with low C-reactive protein levels performed better in the grip strength test. It is important to investigate the adverse effects on functional capacity that can be influenced by inflammatory cytokines in the elderly during aging.

scholarly journals Effects of Interleukin-1β Inhibition With Canakinumab on Hemoglobin A1c, Lipids, C-Reactive Protein, Interleukin-6, and Fibrinogen

Circulation ◽  
2012 ◽  
Vol 126 (23) ◽  
pp. 2739-2748 ◽  
Author(s):  
Paul M Ridker ◽  
Campbell P. Howard ◽  
Verena Walter ◽  
Brendan Everett ◽  
Peter Libby ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Hemoglobin A1c ◽  
Interleukin 1Β ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults

2019 ◽  
Vol 74 (11) ◽  
pp. 1716-1724 ◽  
Author(s):  
Dominique Piber ◽  
Richard Olmstead ◽  
Joshua Hyong-Jin Cho ◽  
Tuff Witarama ◽  
Christian Perez ◽  
...  
Keyword(s):  
Older Adults ◽  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Community Dwelling ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Reactive Protein ◽  
Necrosis Factor

Abstract Systemic inflammation is associated with increasing age. Yet, there are limited data about the association between age and systemic inflammation within older adults, and whether older age is also associated with cellular and nuclear signaling markers of inflammation. In community-dwelling older adults (N = 262, 60–88 years), systemic levels of C-reactive protein, interleukin-6, and soluble tumor necrosis factor receptor II; levels of toll-like receptor-4–stimulated monocytic production of interleukin-6 and tumor necrosis factor α; and resting nuclear levels of activated nuclear factor kappa B and signal transducer and activator of transcription (STAT1, STAT3, STAT5) were evaluated. Adjusting for demographic and clinical factors, multivariate linear regression tested the association between age and each inflammatory marker. Age was positively associated with increased levels of interleukin-6 and soluble tumor necrosis factor receptor II (p’s < .05) and with increases in STAT1, STAT3, and STAT5 activation (p’s < .05). However, no relationship was found between age and C-reactive protein, toll-like receptor-4–stimulated interleukin-6/tumor necrosis factor alpha α production, or nuclear factor kappa B. Within a community-dwelling sample of older adults, older age is associated with increases in STAT activation, along with increases of systemic inflammatory cytokines. In older adults, heterogeneity in age-related increases in inflammatory disease risk may be related to individual variability in inflammation.

A pro-inflammatory diet is associated with increased odds of frailty after 12-year follow-up in a cohort of adults

2021 ◽  
Author(s):  
Courtney L Millar ◽  
Alyssa B Dufour ◽  
Nitin Shivappa ◽  
Daniel Habtemariam ◽  
Joanne M Murabito ◽  
...  
Keyword(s):  
Older Adults ◽  
Interleukin 6 ◽  
C Reactive Protein ◽  
Clinical Registry ◽  
Inflammatory Index ◽  
Reactive Protein ◽  
Heart Study ◽  
Design And Methods

Abstract Background Frailty occurs in 10-15% of community-living older adults and inflammation is a key determinant of frailty. Though diet is a modulator of inflammation, there are few prospective studies elucidating the role of diet-associated inflammation on frailty. Objective To determine whether a pro-inflammatory diet was associated with increased odds of frailty in adults from the Framingham Heart Study (FHS). Design and Methods This study is nested in a prospective cohort that included individuals without frailty. Diet was assessed in 1998-2001 using a valid food frequency questionnaire (FFQ) and frailty was measured in 2011-2014. FFQ-derived energy-adjusted dietary inflammatory index (E-DII®) scores were computed, with higher E-DII scores indicating a more pro-inflammatory diet. Frailty was defined as fulfilling ≥3 of 5 Fried Phenotype criteria. Information on potential mediators, serum interleukin-6 and C-reactive protein was obtained in 1998-2001. Logistic regression estimated odds ratios (OR) and 95% confidence intervals (95% CI) for E-DII (as continuous and in quartiles) and frailty onset adjusting for relevant confounders. Results Of 1,701 individuals without frailty at baseline (mean age = 58 years, SD = 8, range: 33–81; 55% female), 224 developed frailty (13% incidence) over ∼12 years. Mean E-DII score was -1.95 (SD = 2.20; range: -6.71 to +5.40). After adjusting for relevant confounders, a one-unit higher E-DII score was associated with 16% increased odds of developing frailty (95% CI = 1.07, 1.25). In categorical analyses, participants in the highest (pro-inflammatory) vs. lowest quartile of E-DII had &gt;2-fold increased odds of frailty (ORquartile4vs.1 = 2.22, 95% CI = 1.37, 3.60, Ptrend&lt;0.01). Interleukin-6 and C-reactive protein were not major contributors in the pathway. Conclusions In this cohort of middle-aged and older adults, a pro-inflammatory diet was associated with increased odds of frailty over ∼12 years of follow-up. Trials designed to increase consumption of anti-inflammatory foods for frailty prevention are warranted. Clinical registry number and website: Not applicable

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