scholarly journals Lipopolysaccharide-Binding Protein, a Surrogate Marker of Microbial Translocation, Is Associated With Physical Function in Healthy Older Adults

2012 ◽  
Vol 67 (11) ◽  
pp. 1212-1218 ◽  
Author(s):  
J. R. Stehle ◽  
X. Leng ◽  
D. W. Kitzman ◽  
B. J. Nicklas ◽  
S. B. Kritchevsky ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Function ◽  
Binding Protein ◽  
Protein A ◽  
Surrogate Marker ◽  
Microbial Translocation ◽  
Lipopolysaccharide Binding Protein ◽  
Healthy Older Adults ◽  
Lipopolysaccharide Binding

scholarly journals Lipopolysaccharide-Binding Protein: A New Biomarker for Infectious Endocarditis?

2009 ◽  
Vol 55 (2) ◽  
pp. 295-304 ◽  
Author(s):  
Tanja Vollmer ◽  
Cornelia Piper ◽  
Knut Kleesiek ◽  
Jens Dreier
Keyword(s):  
Binding Protein ◽  
Molecular Genetic ◽  
Protein A ◽  
Response To Therapy ◽  
Infectious Endocarditis ◽  
Therapeutic Monitoring ◽  
Lipopolysaccharide Binding Protein ◽  
Reactive Protein ◽  
Wbc Count ◽  
Lipopolysaccharide Binding

Abstract Background: Infectious endocarditis (IE) is a bacterial infection of the endocardium. Diagnosis is based on results obtained from echocardiography, blood cultures, and molecular genetic screening for bacteria and on data for inflammatory markers such as the leukocyte (WBC) count and the C-reactive protein (CRP) concentration. The aim of the present study was to evaluate lipopolysaccharide-binding protein (LBP) as a supportive biomarker for the diagnosis and therapeutic monitoring of IE. Methods: We measured LBP and CRP concentrations and WBC counts in 57 IE patients at hospital admission, 40 patients with noninfectious heart valve diseases (HVDs), and 55 healthy blood donors. The progression of these 3 markers and the influence of cardiac surgery on them were evaluated in 29 IE patients and 21 control patients. Results: Serum LBP concentrations were significantly higher in IE patients [mean (SD), 33.41 (32.10) mg/L] compared with HVD patients [6.67 (1.82) mg/L, P < 0.0001] and healthy control individuals [5.61 (1.20) mg/L]. The progression in the LBP concentration during therapy of IE patients correlated with the changes in the CRP concentration. The 2 markers were equally influenced by antibiotic treatment and surgical intervention. Conclusions: Serial LBP measurement may provide an effective and useful tool for evaluating the response to therapy in IE patients. We found a strong correlation between LBP and CRP concentrations; LBP has a tendency to increase earlier in cases of reinfection.

Old and new findings on lipopolysaccharide-binding protein: a soluble pattern-recognition molecule

2011 ◽  
Vol 39 (4) ◽  
pp. 989-993 ◽  
Author(s):  
Ralf R. Schumann
Keyword(s):  
Binding Protein ◽  
Protein A ◽  
Lipopolysaccharide Binding Protein ◽  
New Findings ◽  
Substantial Progress ◽  
Large Protein Family ◽  
Functional Consequences ◽  
Health And Disease ◽  
Lipopolysaccharide Binding ◽  
Key Questions

LBP [LPS (lipopolysaccharide)-binding protein] was discovered approximately 25 years ago. Since then, substantial progress has been made towards our understanding of its function in health and disease. Furthermore, the discovery of a large protein family sharing functional and structural attributes has helped in our knowledge. Still, key questions are unresolved, and here an overview on the old and new findings on LBP is given. LBP is an acute-phase protein of the liver, but is also synthesized in other cells of the organism. While LBP is named after the ability to bind to LPS of Gram-negative bacteria, it also can recognize other bacterial compounds, such as lipopeptides. It has been shown that LBP is needed to combat infections; however, the main mechanism of action is still not clear. New findings on natural genetic variations of LBP leading to functional consequences may help in further elucidating the mechanism of LBP and its role in innate immunity and disease.

Is lipopolysaccharide-binding protein a useful marker for systemic infection on the ICU?

2001 ◽  
Vol 18 (Supplement 21) ◽  
pp. 119-120
Author(s):  
A. Nierhaus ◽  
B. Montag ◽  
D. Frings ◽  
N. Suerhoff ◽  
J. Schulte am Esch
Keyword(s):  
Binding Protein ◽  
Protein A ◽  
Systemic Infection ◽  
Lipopolysaccharide Binding Protein ◽  
Lipopolysaccharide Binding

Lipopolysaccharide-binding protein: a possible diagnostic marker for Gram-negative bacteremia in neutropenic cancer patients

2003 ◽  
Vol 29 (12) ◽  
pp. 2157-2161 ◽  
Author(s):  
Claudi S. M. Oude Nijhuis ◽  
Edo Vellenga ◽  
Simon M. G. J. Daenen ◽  
Winette T. A. van der Graaf ◽  
Jourik A. Gietema ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Diagnostic Marker ◽  
Binding Protein ◽  
Protein A ◽  
Lipopolysaccharide Binding Protein ◽  
Gram Negative ◽  
Gram Negative Bacteremia ◽  
Lipopolysaccharide Binding

Lipopolysaccharide-binding protein: a potential marker of febrile urinary tract infection in childhood

2013 ◽  
Vol 28 (7) ◽  
pp. 1091-1097 ◽  
Author(s):  
Evanthia A. Tsalkidou ◽  
Emmanouel Roilides ◽  
Stefanos Gardikis ◽  
Gregory Trypsianis ◽  
Alexandros Kortsaris ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Binding Protein ◽  
Protein A ◽  
Lipopolysaccharide Binding Protein ◽  
Febrile Urinary Tract Infection ◽  
Potential Marker ◽  
Lipopolysaccharide Binding

scholarly journals LIPOPOLYSACCHARIDE BINDING PROTEIN IS ASSOCIATED WITH LOWER CVD RISK IN OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S842-S842
Author(s):  
Lisa Roberts ◽  
Thomas W Buford
Keyword(s):  
Older Adults ◽  
Total Cholesterol ◽  
Risk Score ◽  
Binding Protein ◽  
Risk Category ◽  
Gut Permeability ◽  
Lipopolysaccharide Binding Protein ◽  
Cvd Risk ◽  
Risk Categories ◽  
Lipopolysaccharide Binding

Abstract Intestinal (i.e. “gut”) permeability may be related to cardiovascular disease (CVD) risk, but biomarkers for gut permeability are limited and associations with CVD risk are unknown – particularly among older adults. This cross-sectional study aimed to determine if serum biomarkers related to gut permeability [intestinal fatty acid-binding protein (iFABP)] and bacterial toxin clearing [cluster of differentiation 14 (CD14), lipopolysaccharide binding protein (LBP)] are associated with CVD risk among older adults. Older adults (n = 38, 72.0 ± 7.1 years old) were stratified by CVD risk category (Adult Treatment Panel: moderate, high-moderate, high). One-way ANOVAs determined differences in each biomarker by risk category, and associations with risk score were evaluated via linear regression and/or Pearson correlations. LBP (p < 0.001), but not iFABP and CD14 (p’s > 0.05), was significantly different between CVD risk categories. Post-hoc tests indicated LBP was higher in the moderate risk compared to both higher risk categories (p < 0.005). LBP was a significant predictor of 10-year CVD risk (β = -0.629; p = 0.001) and evaluation of individual components in the risk score demonstrated a moderate, positive correlation of LBP with total cholesterol (r = 0.326, p = 0.046). Higher circulating concentrations of LBP were associated with lower CVD risk among older adults. Further, total cholesterol was positively associated with circulating levels of LBP. Importantly, cholesterol assists LBP in clearing bacterial toxins from circulation by transporting toxins for removal. These data suggest LBP may be a key component in reducing CVD risk in older adults.

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