scholarly journals Trajectories of cognitive function and associated factors in community-dwelling older adults: a prospective study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 650-650
Author(s):  
Zimu Wu ◽  
Robyn Woods ◽  
Elsdon Storey ◽  
Trevor Chong ◽  
Raj Shah ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Aging ◽  
Structural Equation ◽  
Cognitive Change ◽  
Community Dwelling ◽  
Cognitive Domain ◽  
Equation Modeling ◽  
Modifiable Factors ◽  
Global Cognition ◽  
Community Dwelling Older Adults

Abstract There is variability in cognitive aging between individuals. This study aimed to investigate cognitive aging trajectories, the associated modifiable factors, and the association of these trajectories with dementia. Community-dwelling older adults (n=19,114) without dementia or major cognitive impairment at inclusion were followed for up to 7 years, with regular standardized cognitive assessments. Group-based (multi-) trajectory modeling identified distinct cognitive trajectories. Structural equation modeling (n=16,018) was used to analyze the associated predictors. Four to seven trajectories were identified per cognitive domain, with generally stable trajectories. Improvement in verbal fluency and minor psychomotor slowing were common. Substantial decline in global cognition and episodic memory were observed in a small proportion of individuals. The highest proportions of dementia cases were in trajectories with major decline in global cognition (56.9%) and memory (33.2%). A number of sociodemographic characteristics, health behaviors and chronic conditions were either directly or indirectly associated with cognitive change in older adults. This study found that some individuals appear resilient to cognitive decline even with advancing age, and that factors that promote healthy cognitive aging are not simply the absence of factors which confer risk for decline.

scholarly journals Multiple Linear Regression-Structural Equation Modeling Based Development of the Integrated Model of Perceived Neighborhood Environment and Quality of Life of Community-Dwelling Older Adults: A Cross-Sectional Study in Nanjing, China

2019 ◽  
Vol 16 (24) ◽  
pp. 4933 ◽  
Author(s):  
Fan Zhang ◽  
Dezhi Li
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Structural Equation ◽  
Daily Life ◽  
Community Dwelling ◽  
Neighborhood Environment ◽  
Equation Modeling ◽  
Community Dwelling Older Adults ◽  
Perceived Neighborhood Environment

Due to the poor functioning in daily living activities, community-dwelling older adults spend more time in their neighborhood environment. The perceived neighborhood environment is crucial to their quality of life (QoL). To explore the complex influences of perceived neighborhood environment on QoL, a questionnaire was designed to measure their perception of each factor of neighborhood environment and each domain of QoL. Based on collected data, the reliability test was applied to revise the questionnaire. Multiple linear regression (MLR) and structural equation modeling (SEM) were adopted to hypothesize and test the integrated model for community-dwelling older adults. The results show that community-dwelling older adults’ perceptions of neighbor support, facilities related to physical exercise and recreation, and accessibility to facilities impact their overall QoL with diverse coefficients of 0.437, 0.312, and 0.295, respectively; neighbor support (0.207) on physical health; sidewalk condition (0.134), natural environment (0.260), and facilities related to daily life (0.165) on psychological health; and neighbor support (0.298), facilities related to daily life (0.206), and design-related safety (0.225) on social relationship. This revealed that perceptions of neighborhood environment have diverse impacts on their QoL. This study can provide targeted retrofit strategies for communities to enhance QoL of community-dwelling older adults efficiently.

Accelerated Epigenetic Age in Normal Cognitive Aging of Korean Community-Dwelling Older Adults

2021 ◽  
pp. 109980042098389
Author(s):  
Jongmin Park ◽  
Chang Won Won ◽  
Leorey N. Saligan ◽  
Youn-Jung Kim ◽  
Yoonju Kim ◽  
...  
Keyword(s):  
Older Adults ◽  
Dna Methylation ◽  
Cognitive Function ◽  
Cognitive Aging ◽  
Community Dwelling ◽  
Test Results ◽  
Cohen’S D ◽  
Epigenetic Age ◽  
Epigenetic Age Acceleration ◽  
Community Dwelling Older Adults

Background: Epigenetic age acceleration has been studied as a promising biomarker of age-related conditions, including cognitive aging. This pilot study aims to explore potential cognitive aging-related biomarkers by investigating the relationship of epigenetic age acceleration and cognitive function and by examining the epigenetic age acceleration differences between successful cognitive aging (SCA) and normal cognitive aging (NCA) among Korean community-dwelling older adults (CDOAs). Methods: We used data and blood samples of Korean CDOAs from the Korean Frailty and Aging Cohort Study. The participants were classified into two groups, SCA (above the 50th percentile in all domains of cognitive function) and NCA. The genome-wide DNA methylation profiling array using Illumina Infinium MethylationEPIC BeadChip was used to calculate the following: the DNA methylation age, universal epigenetic age acceleration, intrinsic epigenetic age acceleration (IEAA), and extrinsic epigenetic age acceleration (EEAA). We also used Pearson correlation analysis and independent t-tests to analyze the data. Results: Universal age acceleration correlated with the Frontal Assessment Battery test results ( r = −0.42, p = 0.025); the EEAA correlated with the Word List Recognition test results ( r = −0.41, p = 0.027). There was a significant difference between SCA and NCA groups in IEAA ( p = 0.041, Cohen’s d = 0.82) and EEAA ( p = 0.042, Cohen’s d = 0.78). Conclusions: Epigenetic age acceleration can be used as a biomarker for early detection of cognitive decline in Korean community-dwelling older adults. Large longitudinal studies are warranted.

scholarly journals Using structural equation modeling in the understanding of functional disability in older adults

2021 ◽  
Vol 29 ◽  
Author(s):  
Darlene Mara dos Santos Tavares ◽  
Nayara Gomes Nunes Oliveira ◽  
Flavia Aparecida Dias Marmo ◽  
Joilson Meneguci
Keyword(s):  
Older Adults ◽  
Sedentary Behavior ◽  
Structural Equation ◽  
Functional Disability ◽  
Depressive Symptomatology ◽  
Age Groups ◽  
Community Dwelling ◽  
Likelihood Method ◽  
Equation Modeling ◽  
Cross Sectional

Objective: to analyze functional disability and its associated factors among community-dwelling older adults. Method: a cross-sectional study, conducted with 1,635 older adults distributed in the following age groups: 60 to 69, 70 to 79, and 80 years old or more, living in a health macro-region of the state of Minas Gerais. Descriptive and trajectory analysis was carried out (p<0.05). The parameters were estimated by the Maximum Likelihood method. Results: the highest percentage was female, with a monthly income of 1 minimum wage and living with a companion. In the age groups from 60 to 69 and from 70 to 79 years old, older adults with a partner predominated; and, among those aged 80 years old or more, widowed individuals prevailed. In the three groups, functional disability occurred hierarchically. Lower schooling, frailty and depressive symptomatology were factors directly associated with functional disability in the advanced activities; frailty and sedentary behavior were directly associated with functional disability in the instrumental activities. In the older adults aged between 60 and 69 years old and from 70 to 79 years old, sedentary behavior was associated with greater dependence on the basic activities. Conclusion: the expanded understanding of the factors in the functional disability of the older adults, according to age group, helps the health professional in the development of preventive measures for this disease.

scholarly journals Effects of APOE on cognitive aging in community-dwelling older adults.

2019 ◽  
Vol 33 (3) ◽  
pp. 406-416 ◽  
Author(s):  
Emilie T. Reas ◽  
Gail A. Laughlin ◽  
Jaclyn Bergstrom ◽  
Donna Kritz-Silverstein ◽  
Elizabeth Barrett-Connor ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Aging ◽  
Community Dwelling ◽  
Aging In Community ◽  
Community Dwelling Older Adults

Predictors of satisfaction with life among older adults

2017 ◽  
Vol 41 (S1) ◽  
pp. S177-S178
Author(s):  
S. Von Humboldt ◽  
I. Leal
Keyword(s):  
Older Adults ◽  
Sex Education ◽  
Adult Children ◽  
Sense Of Coherence ◽  
Structural Equation ◽  
Structural Model ◽  
Satisfaction With Life ◽  
Community Dwelling ◽  
Equation Modeling ◽  
Health Related

IntroductionIncreasing longevity brings challenges for older adults’ satisfaction with life (SWL).AimsThis study aims at exploring a structural model of predictors of SWL in a cross-national sample of older adults.MethodsA community-dwelling sample of 1234 older adults was assessed regarding SWL, sense of coherence (SOC) and socio-demographic, lifestyle and health-related characteristics. Structural equation modeling was used to investigate a structural model of the self-reported SWL, comprising SOC, socio-demographic characteristics (age, sex, education, marital and professional status, household, adult children, income, living setting and religion), lifestyle and health-related characteristics (physical activity, recent disease and medication).ResultsSignificant predictors are SOC (β = .733; P < .001), religion (β = .725; P < .001), income (β = .551; P < .001), adult children (β = .546; P < .001), education (β = –.403; P < .001), living setting (β = –.292; P < .001) and medication (β = –.197; P < .001). The variables accounted for 24.8% of the variability of SWL. Moreover, differences between the four nationality groups (F(3, 671) = 3.671, P = .066) were not found concerning SWL.ConclusionsSense of coherence is the strongest predictor of self-reported SWL. Other predictors are religion, income, adult children, education, living setting and medication. The four nationalities did not present significant differences, concerning SWL. This study highlights the factors that influence older adults’ SWL, namely, SOC, religion and income, as promoters of aging well, within a salutogenic model of health for older populations.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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