scholarly journals OLD-AGE DEPRESSIVE SYMPTOMS: THE ROLE OF EARLY-LIFE FINANCIAL STRAIN AND LATE-LIFE SOCIAL ENGAGEMENT

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S5-S6
Author(s):  
Federico Triolo ◽  
Linnea Sjöberg ◽  
Davide Vetrano ◽  
Alexander Darin-Mattsson ◽  
Marco Bertolotti ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Old Age ◽  
Social Engagement ◽  
Repeated Measures ◽  
Early Life ◽  
Rating Scale ◽  
Leisure Activities ◽  
Late Life ◽  
Financial Strain ◽  
National Study

Abstract It remains unclear if childhood socioeconomic disadvantage is associated with depression in old age. This study aims to investigate the effect of childhood financial strain on depressive symptoms in old age, and to examine whether late-life social engagement modifies this association. Data from the Swedish National study of Aging and Care in Kungsholmen, a community-based longitudinal study of aging, spanning clinical assessments over 15 years of follow-up were used. Information on financial strain in childhood was collected at baseline. Repeated measures of the Montgomery–Åsberg Depression Rating Scale were used to define depressive trajectories. A social engagement index comprised information on baseline social network and leisure activities. Linear mixed models were used to estimate depressive trajectories. Childhood financial strain was associated with a higher level of depressive symptoms (β = 0.36; p<0.05), but not the rate of symptom accumulation over time. Relative to those with a combination of no financial strain and active social engagement, the level of depressive symptoms was progressively increased in those without financial strain but with inactive social engagement (β = 0.29; p<0.05), as well as in those with both financial strain and inactive engagement (β= 0.83; p<0.05). Individuals with financial strain who had active social engagement exhibited a similar burden of symptoms as those without financial strain and with rich social engagement. Early-life financial strain may have a lasting effect on old age depressive symptoms, although its detrimental consequences may be modified by active social engagement in late life.

scholarly journals Social engagement in late life may attenuate the burden of depressive symptoms due to financial strain in childhood

2020 ◽  
Vol 263 ◽  
pp. 336-343 ◽  
Author(s):  
Federico Triolo ◽  
Linnea Sjöberg ◽  
Davide L. Vetrano ◽  
Alexander Darin-Mattsson ◽  
Marco Bertolotti ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Social Engagement ◽  
Late Life ◽  
Financial Strain

scholarly journals PROTECTIVE EFFECT OF LIFETIME EXPERIENCES ON FUNCTIONAL STATUS IN YOUNG-ONSET DEMENTIA

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S118-S119 ◽  
Author(s):  
Tram N Pham ◽  
Lauren Massimo ◽  
Katheryn A Cousins
Keyword(s):  
Functional Status ◽  
Disease Duration ◽  
Rating Scale ◽  
Leisure Activities ◽  
Late Life ◽  
Clinical Dementia Rating ◽  
Young Onset ◽  
Young Onset Dementia ◽  
The Relationship ◽  
Cognitive Lifestyle

Abstract Patients with Frontotemporal degeneration (FTD), a common form of young-onset dementia, experience decline in cognitive, social and daily functioning as the disease progresses. Research shows that lifestyle factors may be an important modifiable risk factor for dementia, but this has not been well studied in FTD. In this study, we test the hypothesis that lifetime experiences, including education, occupation, and leisure activities, are associated with better functional status in individuals with FTD. We also evaluated the relationship between timing of experiences (early, mid-life, and late-life) and functional status. Thirty-five patients (mean age 61.6±8.7; 74% male; mean disease duration 3.4 ± 2.6; mean MMSE 24.0 ± 5.5) completed the Lifetime of Experiences Questionnaire (LEQ), a comprehensive assessment of lifelong cognitive lifestyle, and the Clinical Dementia Rating Scale (CDR), which was used to assess functional status. Linear regression tested the relationship between cognitive lifestyle and functional status, with age and disease duration included as covariates. Higher total LEQ score was associated with better functional status (lower score on CDR) (β = -0.047, p = 0.009). While Young Adulthood LEQ score was not significantly associated with total CDR (β = -0.047, p = 0.176), both Mid-life (β = -0.117, p = 0.011) and Late-life (β = -0.133, p = 0.013) LEQ score significantly contributed to functional status. Our results indicate that functional status is mediated in part by cognitive lifestyle and that experiences accumulated in mid-life and late-life have a greater effect on functional status at time of diagnosis.

scholarly journals Social Relationships in Early Life and Episodic Memory in Mid- and Late Life

2020 ◽  
Author(s):  
Zhenmei Zhang ◽  
Hongwei Xu ◽  
Lydia W Li ◽  
Jinyu Liu ◽  
Seung-won Emily Choi
Keyword(s):  
Episodic Memory ◽  
Social Relationships ◽  
Social Engagement ◽  
Early Life ◽  
Memory Performance ◽  
Late Life ◽  
Parent Child Relationship ◽  
Variable Approach ◽  
Retrospective Reports ◽  
Lagged Dependent Variable

Abstract Objectives This study examines the longitudinal relationships between retrospective reports of early-life social relationships (i.e., having good friends, parent–child relationship quality, and childhood neighborhood social cohesion) and episodic memory in China. Methods We analyzed 2 waves of data (2011 and 2015) from the China Health and Retirement Longitudinal Study. The analytical sample included 9,285 respondents aged 45 and older at baseline. A lagged dependent variable approach was used to estimate the associations between measures of early-life social relationships and episodic memory change at the study’s 4-year follow-up. Results Retrospective reports of better early-life social relationships are significantly associated with higher levels of episodic memory performance in 2015 among middle-aged and older Chinese, controlling for episodic memory in 2011, childhood socioeconomic status, adulthood sociodemographic variables, and the history of stroke. Educational attainment accounts for a significant portion of the associations between early-life social relationships and episodic memory. In contrast, mental health and social engagement in adulthood account for a small part of these associations. Discussion The findings suggest that positive early-life social relationships are beneficial for episodic memory in mid- and late life, and more research is needed to examine the underlying mechanisms.

Social Engagement and Depressive Symptoms in Late Life

2006 ◽  
Vol 18 (4) ◽  
pp. 604-628 ◽  
Author(s):  
Thomas A. Glass ◽  
Carlos F. Mendes De Leon ◽  
Shari S. Bassuk ◽  
Lisa F. Berkman
Keyword(s):  
Depressive Symptoms ◽  
Social Engagement ◽  
Late Life

scholarly journals Association of Early-Life Family and Nieghborhood Circumstances With Depressive Symptoms in Chinese Older Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 441-442
Author(s):  
Yan Chen ◽  
Jie Tan
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Depressive Symptoms ◽  
Old Age ◽  
Early Life ◽  
Strong Association ◽  
Community Dwelling ◽  
Bivariate Analysis ◽  
Life Circumstances ◽  
Community Dwelling Older Adults

Abstract A growing body of literature suggests that early life circumstances can influence mental health throughout the lifespan. However, how these early life circumstances cumulatively contribute to depression in old age is not completely understood. The present study examined the associations of eight factors representing multifaceted early life experience at individual, family, and community levels with depression among community-dwelling older adults. Data were from the China Health and Retirement Longitudinal Study. We included 8,239 community-dwelling individuals who were ≥60 years, completed the life history questionnaire, and had assessment of depression. Chi-square test was used to examine the unadjusted associations between each of the eight early life risk factors and depression. An early life disadvantage index was established using risk factors that were significantly associated with depression. Logistic regression was used to examine the association of each early life risk factor and the index with depression. Of 8,239 individuals included, 2,055 (24.9%) had depression. In bivariate analysis, each of eight early life risk factors was significantly associated with depression. Except for maternal and paternal education, all risk factors persisted to be associated with depression after multivariable adjustment. In the multivariable-adjusted model, a one-point higher in the early life disadvantage index (range: 0-6) was associated with a 45% (95% CI: 37%, 53%) higher odds of depression. There was a strong association between early life environments and depressive symptoms among Chinese community-dwelling older adults. Adverse early life circumstances could contribute cumulatively to depression in old age.

scholarly journals Linking early life risk factors to frailty in old age: evidence from the China Health and Retirement Longitudinal Study

2020 ◽  
Vol 49 (2) ◽  
pp. 208-217 ◽  
Author(s):  
Yaxi Li ◽  
Qian-Li Xue ◽  
Michelle C Odden ◽  
Xi Chen ◽  
Chenkai Wu
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Longitudinal Study ◽  
Health Status ◽  
Old Age ◽  
Early Life ◽  
Late Life ◽  
Community Dwelling ◽  
Childhood And Adolescence ◽  
Childhood Health

Abstract Background exposures in childhood and adolescence may impact the development of diseases and symptoms in late life. However, evidence from low- and middle-income countries is scarce. In this cross-sectional study, we examined the association of early life risk factors with frailty amongst older adults using a large, nationally representative cohort of community-dwelling Chinese sample. Methods we included 6,806 participants aged $\ge$60 years from the China Health and Retirement Longitudinal Study. We measured 13 risk factors in childhood or adolescence through self-reports, encompassing six dimensions (education, family economic status, nutritional status, domestic violence, neighbourhood and health). We used multinomial regression models to examine the association between risk factors and frailty. We further calculated the absolute risk difference for the statistically significant factors. Results persons with higher personal and paternal education attainment, better childhood neighbourhood quality and better childhood health status had lower risk of being frail in old age. Severe starvation in childhood was associated with higher risk of prefrailty. The risk differences of being frail were 5.6% lower for persons with a high school or above education, 1.5% lower for those whose fathers were literate, 4.8% lower for the highest neighbourhood quality and 2.9% higher for worse childhood health status compared to their counterparts. Conclusions unfavorable socioeconomic status and worse health condition in childhood and adolescence may increase the risk of late-life frailty amongst Chinese older adults.

scholarly journals Bridging late-life depression and chronic somatic diseases: a network analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Federico Triolo ◽  
Martino Belvederi Murri ◽  
Amaia Calderón-Larrañaga ◽  
Davide Liborio Vetrano ◽  
Linnea Sjöberg ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Disease Burden ◽  
Late Life ◽  
National Study ◽  
Late Life Depression ◽  
Suicidal Thoughts ◽  
Disease Clusters ◽  
Cognitive Difficulties ◽  
Somatic Disease ◽  
Somatic Diseases

AbstractThe clinical presentation of late-life depression is highly heterogeneous and likely influenced by the co-presence of somatic diseases. Using a network approach, this study aims to explore how depressive symptoms are interconnected with each other, as well as with different measures of somatic disease burden in older adults. We examined cross-sectional data on 2860 individuals aged 60+ from the Swedish National Study on Aging and Care in Kungsholmen, Stockholm. The severity of sixteen depressive symptoms was clinically assessed with the Comprehensive Psychopathological Rating Scale. We combined data from individual clinical assessment and health-registers to construct eight system-specific disease clusters (cardiovascular, neurological, gastrointestinal, metabolic, musculoskeletal, respiratory, sensory, and unclassified), along with a measure of overall somatic burden. The interconnection among depressive symptoms, and with disease clusters was explored through networks based on Spearman partial correlations. Bridge centrality index and network loadings were employed to identify depressive symptoms directly connecting disease clusters and depression. Sadness, pessimism, anxiety, and suicidal thoughts were the most interconnected symptoms of the depression network, while somatic symptoms of depression were less interconnected. In the network integrating depressive symptoms with disease clusters, suicidal thoughts, reduced appetite, and cognitive difficulties constituted the most consistent bridge connections. The same bridge symptoms emerged when considering an overall measure of somatic disease burden. Suicidal thoughts, reduced appetite, and cognitive difficulties may play a key role in the interconnection between late-life depression and somatic diseases. If confirmed in longitudinal studies, these bridging symptoms could constitute potential targets in the prevention of late-life depression.

scholarly journals Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression?

2020 ◽  
Vol 34 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Mardien Leoniek Oudega ◽  
Amna Siddiqui ◽  
Mike P. Wattjes ◽  
Frederik Barkhof ◽  
Mara ten Kate ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
White Matter ◽  
Older Patients ◽  
White Matter Hyperintensities ◽  
Rating Scale ◽  
Brain Magnetic Resonance Imaging ◽  
Late Life ◽  
Late Life Depression ◽  
Symptom Profile ◽  
Interest And Motivation

Objective: Apathy symptoms are defined as a lack of interest and motivation. Patients with late-life depression (LLD) also suffer from lack of interest and motivation and previous studies have linked apathy to vascular white matter hyperintensities (WMH) of the brain in depressed and nondepressed patients. The aim of this study was to investigate the relationship between apathy symptoms, depressive symptoms, and WMH in LLD. We hypothesize that late-onset depression (LOD; first episode of depression after 55 years of age) is associated with WMH and apathy symptoms. Methods: Apathy scores were collected for 87 inpatients diagnosed with LLD. Eighty patients underwent brain magnetic resonance imaging. Associations between depressive and apathy symptoms and WMH were analyzed using linear regression. Results: All 3 subdomains of the 10-item Montgomery–Åsberg Depression Rating Scale correlated significantly with the apathy scale score (all P < .05). In the total sample, apathy nor depressive symptoms were related to specific WMH. In LOD only, periventricular WMH were associated with depression severity (β = 5.21, P = .04), while WMH in the left infratentorial region were associated with apathy symptoms (β coefficient = 5.89, P = .03). Conclusion: Apathy and depressive symptoms are highly overlapping in the current cohort of older patients with severe LLD, leading to the hypothesis that apathy symptoms are part of depressive symptoms in the symptom profile of older patients with severe LLD. Neither apathy nor depressive symptoms were related to WMH, suggesting that radiological markers of cerebrovascular disease, such as WMH, may not be useful in predicting these symptoms in severe LLD.

scholarly journals Phenomenology of depression in older compared with younger adults: Meta-analysis

2012 ◽  
Vol 200 (4) ◽  
pp. 275-281 ◽  
Author(s):  
J. M. Hegeman ◽  
R. M. Kok ◽  
R. C. van der Mast ◽  
E. J. Giltay
Keyword(s):  
Major Depression ◽  
Early Life ◽  
Rating Scale ◽  
Sexual Interest ◽  
Meta Analysis ◽  
Age Groups ◽  
Late Life ◽  
Late Life Depression ◽  
Single Item ◽  
Item Level

BackgroundLate-life depression may differ from early-life depression in its phenomenology.AimsTo investigate the effect of age on the phenomenology of major depression.MethodA systematic search was conducted in PubMed, Embase and PsycINFO for all studies examining the relation between age and phenomenology of major depression according to RDC, DSM and ICD criteria. Studies were included only if the age groups were compared at the single-item level using the 17-, 21- or 24-item versions of the Hamilton Rating Scale for Depression; a meta-analysis was done for each item of the 17-item scale.ResultsEleven papers met the inclusion criteria. Older depressed adults, compared with younger depressed adults, demonstrated more agitation, hypochondriasis and general as well as gastrointestinal somatic symptoms, but less guilt and loss of sexual interest.ConclusionsThe phenomenology of late-life depression differs only in part from that of early-life depression. Major depression in older people may have a more somatic presentation, whereas feelings of guilt and loss of sexual function may be more prevalent in younger people.

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