scholarly journals Limitations of right ventricular annular parameters in the early postoperative period following pulmonary endarterectomy: an observational study

2020 ◽  
Vol 31 (2) ◽  
pp. 191-198
Author(s):  
Saida Rézaiguia-Delclaux ◽  
François Haddad ◽  
Catherine Pilorge ◽  
Myriam Amsallem ◽  
Elie Fadel ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Postoperative Period ◽  
Left Ventricular ◽  
Early Postoperative Period ◽  
Area Ratio ◽  
Pulmonary Resistance ◽  
Pulmonary Endarterectomy ◽  
Surgical Success ◽  
Before And After ◽  
The Relationship

Abstract OBJECTIVES Echocardiographic right ventricular (RV) annular parameters are probably not as reliable to evaluate the surgical success in the postoperative period after pulmonary endarterectomy (PEA), whereas RV end-diastolic/left ventricular end-diastolic area ratio (RVEDA/LVEDA ratio) could be more useful. This study examined the relationship between RV annular parameters or RVEDA/LVEDA ratio and ideal cardiac index (ICI), before and after PEA. METHODS Among 80 patients who underwent PEA, the relationships between RVEDA/LVEDA ratio (21 patients), or tricuspid annular plane systolic excursion (32 patients), or systolic tricuspid annular velocity (55 patients) and ICI were modelled. RESULTS Forty-eight hours following PEA, mean pulmonary artery pressure decreased (26 ± 6 vs 46 ± 12 mmHg, P < 0.0001) and ICI improved (2.8 ± 0.8 vs 3.0 ± 0.9 l/min/m2, P = 0.02). In contrast to the moderate association between RV annular indices and ICI in the preoperative period, no significant relationship was found in the postoperative period (r = 0.54 and 0.17 for tricuspid annular plane systolic excursion and r = 0.46 and 0.16 for systolic tricuspid annular velocity, respectively). The RVEDA/LVEDA ratio significantly decreased postoperatively (0.97 ± 0.21 vs 1.19 ± 0.43, P = 0.002) and was correlated with ICI both in preoperative and postoperative periods (r = 0.57 and 0.57, respectively). There was a significant correlation between changes in RVEDA/LVEDA ratio and changes in total pulmonary resistance CONCLUSIONS Improved ICI and RVEDA/LVEDA ratio reflected the surgical success of PEA and lowering of total pulmonary resistances. In contrast to the RV/left ventricular area ratio, annular RV indices associated poorly with postoperative ICI. Recognizing this limitation is important in minimizing the overdiagnosis of RV dysfunction after PEA.

scholarly journals The use of enoxaparin as bridge to therapeutic INR after LVAD implantation

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Zubair Shah ◽  
Ioannis Mastoris ◽  
Prakash Acharya ◽  
Aniket S. Rali ◽  
Moghni Mohammed ◽  
...  
Keyword(s):  
Postoperative Period ◽  
Left Ventricular ◽  
Early Postoperative Period ◽  
Index Admission ◽  
Ventricular Assist Devices ◽  
Left Ventricular Assist Devices ◽  
Bleeding Events ◽  
Ventricular Assist ◽  
Safety Outcome

Abstract Background Left ventricular assist devices (LVAD) have been increasingly used in the treatment of end-stage heart failure. While warfarin has been uniformly recommended in the long-term as anticoagulation strategy, no clear recommendation exists for the post-operative period. We sought to evaluate the feasibility of enoxaparin in the immediate and early postoperative period after LVAD implantation. Methods This is a two-center, retrospective analysis of 250 consecutive patients undergoing LVAD implantation between January 2017 and December 2018. Patients were bridged postoperatively to therapeutic INR by either receiving unfractionated heparin (UFH) or low molecular weight heparin (LMWH). Patients were followed while inpatient and for 3 months after LVAD implantation. The efficacy outcome was occurrence of first and subsequent cerebrovascular accident while safety outcome was the occurrence of bleeding events. Length of stay (LOS) was also assessed. Results Two hundred fifty and 246 patients were analyzed for index admission and 3-month follow up respectively. No statistically significant differences were found between the two groups in CVA (OR = 0.67; CI = 0.07–6.39, P = 0.73) or bleeding events (OR = 0.91; CI = 0.27–3.04, P = 0.88) during index admission. Similarly, there were no differences at 3 months in either CVAs or bleeding events (OR = 0.85; 0.31–2.34; p = 0.76). No fatal events occurred during the study follow-up period. Median LOS was significantly lower (4 days; p = 0.03) in the LMWH group. Conclusions LMWH in the immediate and early postoperative period after LVAD implantation appears to be a concurrently safe and efficacious option allowing earlier postoperative discharge and avoidance of recurrent hospitalizations due to sub-therapeutic INR.

scholarly journals Longitudinal mechanics as predictors of left ventricular systolic function in the early postoperative period after surgical perimembranous ventricular septal defect closure in children aged <1 year

2019 ◽  
Vol 23 (1) ◽  
pp. 17
Author(s):  
Yu. S. Sinelnikov ◽  
E. N. Orekhova ◽  
T. V. Matanovskaya
Keyword(s):  
Postoperative Period ◽  
Septal Defect ◽  
Systolic Function ◽  
Systolic Dysfunction ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Early Postoperative Period ◽  
Volume Index ◽  
Perimembranous Ventricular Septal Defect ◽  
Lv Systolic Function

<p><strong>Aim.</strong> To evaluate left ventricular systolic function in the early postoperative period after surgical perimembranous ventricular septal defect (VSD) closure in children aged &lt;1 year using longitudinal mechanics.</p><p><strong>Methods.</strong> Between 2014 and 2017, we examined 65 children aged 2–11 months with perimembranous VSD (mean diameter = 8.6 ± 1.7 mm) and a pulmonary-to-systemic blood flow ratio of &gt;1.5/1. The longitudinal mechanics of the left ventricle (LV) were assessed using vector velocity imaging. All the children underwent surgical perimembranous VSD closure. Echocardiographic studies were performed preoperatively, immediately postoperatively, and 1 and 20 days postoperatively.</p><p><strong>Results.</strong> In all the children, significant decreases in the LV end-systolic volume index, end-diastolic volume index, stroke volume index (SVI), and ejection fraction (EF) were identified immediately postoperatively when compared with the preoperative findings. One day postoperatively, the LV volume data normalized; however, in 10.8% of the children, the SVI and EF remained impaired. The percentage EF reduction showed weak correlations with the childrens’ weights (Rs = 0.3; p = 0.039), aortic cross-clamping durations (Rs = 0.36; p = 0.03), and VSD sizes (Rs = 0.33; p = 0.006). Twenty days postoperatively, the LV volumetric parameters normalized; however, the EF did not reach the initial value. The longitudinal strain and strain rate were reduced preoperatively when compared with normal values. For the prediction of a postoperatively significant EF reduction (≤35%), the preoperative LV strain had a sensitivity of 88%, specificity of 98.2%, and cutoff value of –9.2%; the LV strain rate had a sensitivity of 87.8%, specificity of 94.7%, and cutoff value of –0.47 s<sup>−</sup><sup>1</sup>.</p><p><strong>Conclusion.</strong> Children aged &lt;1 year with perimembranous VSD showed reductions in the longitudinal mechanics of the LV, reflecting subclinical systolic dysfunction. One day after surgical correction, a transient decrease in LV systolic function was noted in all the children; however, a significantly impaired LV systolic function was noted in 10.8% of the children. Our findings indicate that the longitudinal mechanics of the LV can predict LV systolic dysfunction in the early postoperative period with high sensitivity and specificity.</p><p>Received 17 January 2019. Revised 18 April 2019. Accepted 25 April 2019.</p><p><strong>Funding:</strong> The study did not have sponsorship.</p><p><strong>Conflict of interest:</strong> Authors declare no conflict of interest.</p>

scholarly journals BLOOD COAGULATION SYSTEM AND PERSONALIZATION OF TREATMENT IN PATIENTS WITH IMPLANTED SYSTEM OF LEFT VENTRICLE ASSIST DEVICE IN THE EARLY POSTOPERATIVE PERIOD

2020 ◽  
pp. 43-48
Author(s):  
О. П. Мазуренко ◽  
П. Надзякевич ◽  
О. А. Лоскутов ◽  
Л. В. Згржебловська
Keyword(s):  
Left Ventricle ◽  
Blood Coagulation ◽  
Postoperative Period ◽  
Blood Circulation ◽  
Left Ventricular ◽  
Early Postoperative Period ◽  
Coagulation System ◽  
Mechanical Support ◽  
Blood Coagulation System ◽  
Membrane Oxygenation

The work is devoted to the study of the blood coagulation system and the correction of its indicators with a personalized anticoagulant target therapy in the early postoperative period to ten patients with implanted left ventricle assist devices for mechanical circulation support in the Silesian Center Heart Diseases, according to a bilateral agreement with the National Medical Academy of Postgraduate Education named after P. Shupik. The study included ten patients who were implanted in the Silesian Center for Heart Disease from March 11, 2016 to Nov 22, 2017, devices for mechanical support of left ventricular circulation LVAD in the aftermath of the terminal stage of heart failure.The subjects were men 55 ± 13.5 years old, with a body mass index of 30.8 ± 8.3 and a body surface area of 2.12 ± 0.2 m2 with a left ventricular ejection fraction of 15.4 ± 9.5%, which was mechanically supported blood circulation in the period from 11.03.2016 to 22.11.2017 in conditions of artificial blood circulation and combined endotracheal anesthesia, five of which had implanted cardioverts-defibrillators.Patients were divided according to the INTERMAKS Level 1 (cardiogenic shock) - 6 (60% of cases), Level 2 (progressive circulatory failure) - 4 men (40% of cases). Patients in the early postoperative period that time received an anticoagulant target mono and combination therapy with heparin (6-11U / kg / h), Aspirin (75-150mg.), Clopidogrel (75-150mg.), Warfarin (1.5-7mg), Nadroparinum Ca(0.3-0.6 ml / 2p / d), Fondaparinux Na (2.5-5 mg / 2p / d). The duration of support - POLVAD ranged from 102 to 156 days. Results - transplanted 2, died 2. The studies revealed a non-linear relationship between mortality, the number of days of general and intensive therapy for hospitalization, the use of extracorporeal membrane oxygenation and intra-aortic membrane oxygenation in patients with implanted systems of mechanical blood circulation, who used large doses of catecholamines during the postoperative period.Analyzing the needs of patients with implanted mechanical systems to support the blood circulation of the left ventricle in blood donations, it should be noted that in the early postoperative period the erythrocyte mass was most often used. During surgery, fresh-frozen plasma was the drug of choice, while the platelet mass was used in most cases during the pre-operative preparation of the patient.The main complications that developed in patients with implanted mechanical support systems of the left ventricular blood circulation were: bleeding, thrombosis of the mechanical blood circulation systems, cerebral circulation disorders due to hemorrhagic and ischemic type, infectious complications.

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