scholarly journals 1255Associations between select lifestyle behaviours and quality of life based on MS phenotype

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Nupur Nag ◽  
Maggie Yu ◽  
Steve Simpson-Yap ◽  
Sandra Neate ◽  
Hollie Schmidt
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Leisure Time Physical Activity ◽  
Fine Motor ◽  
Lifestyle Behaviours ◽  
Supplement Use ◽  
Point Increase ◽  
Diet And Physical Activity ◽  
Diet Type

Abstract Background Multiple sclerosis (MS) comprises progressive and non-progressive phenotypes, both presenting with symptoms that may reduce quality of life (QoL). Lifestyle behaviours, including diet, exercise, and wellness activities, are associated with higher QoL, however little is known about differences by MS phenotype. We assessed associations between lifestyle behaviours and QoL, between progressive vs non-progressive MS. Methods Self-reported cross-sectional data from the iConquerMS study (n = 1,109) were analysed. Lifestyle behaviours were queried via tick-box options for diet-type, supplement use, and wellness activities; and physical activity via Godin-Shephard Leisure-Time Physical Activity Questionnaire. QoL was queried via Neuro-QoL. Linear regression, adjusted for age, sex, BMI, education, disability, and MS duration, was used to assess associations and moderation analyses to assess differences between MS phenotypes. Results Diet-type, physical activity, and wellness activities were associated with specific QoL subdomains. Only associations between diet and physical activity, with QoL subdomains, differed between phenotypes. Anti-inflammatory diets were associated with a 1.5-point increase in mobility in progressive MS. In non-progressive MS, high physical activity was associated with a 3.6-point decrease in depression, and a 4.2-, 2.3- and 3.0-point increase in positive affect, fine motor skills, and social participation, respectively. Conclusions Specific lifestyle behaviours were associated with QoL subdomains. Associations between diet and physical activity with QoL differed between MS phenotype. Key messages Specific lifestyle behaviours are associated with higher QoL. Lifestyle interventions for MS management should consider disease course.

scholarly journals P550 Short term effects of a combined lifestyle intervention in patients with Inflammatory Bowel Disease

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S518-S518
Author(s):  
C R Lamers ◽  
N M de Roos ◽  
H H Heerink ◽  
L A van de Worp - Kalter ◽  
B J M Witteman
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Disease Activity ◽  
Lifestyle Intervention ◽  
Daily Life ◽  
Clinical Disease ◽  
Clinical Disease Activity ◽  
Diet And Physical Activity ◽  
Inflammatory Bowel

Abstract Background Diet and physical activity might help to improve quality of life and maintain remission in patients with inflammatory bowel disease (IBD). In other conditions, interventions in which diet and physical activity are combined seem to be more effective than separate interventions. Therefore, we assessed the effect of a combined lifestyle intervention on the impact of disease on daily life, clinical disease activity, fatigue and quality of life in patients with Crohn’s disease (CD) or ulcerative colitis (UC). Methods A single arm intervention study was performed in IBD patients in remission or with mildly active disease. Participants received personal advice to improve their diet and level of physical activity by a dietician and a physiotherapist in one face-to-face and one telephone consult. These advices were supported by guidelines based on the Dutch dietary and physical activity guidelines, a recipe app and a booklet with physical activity exercises. IBD disability index (IBD-DI) to assess impact of disease on daily life, clinical disease activity questionnaires (P-HBI or P-SCCAI), IBD fatigue (IBD-F) patient self-assessment scale and IBD quality of life questionnaire (IBDQ) were completed. The Eetscore Food Frequency Questionnaire (Eetscore FFQ) and Short Questionnaire to Assess Health-enhancing physical activity (SQUASH) were used to assess diet and physical activity. Changes from baseline to 5 weeks after start were investigated by paired samples t-tests or Wilcoxon signed rank tests. Results We included 29 participants. At time of this preliminary analysis, 25 participants completed baseline and 5-week assessments (11 males, 11 CD, median age 36 years [IQR 29–53], median BMI 25 kg/m2 [IQR 24–28]). After 5 weeks, diet quality had significantly improved (p<0.001), but level of physical activity had not (p=0.509). Impact of disease on daily life (IBD-DI) decreased with 2.5 points (95%CI -5.5-0.4; p=0.09). Disease activity did not change significantly. There was a significant decrease in fatigue (median IBD-F 20 [IQR 8–29] to 15 [IQR 3–24; p=0.03]) and a significant increase in quality of life (median IBDQ 194 [IQR 179–206] to 196 [IQR 186–209; p=0.03]). Conclusion These preliminary results suggest that a combined lifestyle intervention is effective to reduce fatigue and to increase quality of life in patients with IBD, at least in the short term. Impact of disease on daily life and clinical disease activity did not improve significantly. Participants reported their level of physical activity to be restricted due to COVID-19 measures, which could explain the lack of effect on this outcome. This study is still ongoing and we expect follow-up data up till 1 year after start.

Abstract 19586: Impact of Dyspnea: From Validity Indices to the Clinical Utility of the French-canadian Version of the Modified Dyspnea Index

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Michel Dore ◽  
Maria-Cecilia Gallani ◽  
Steeve Provencher ◽  
Paul Poirier ◽  
Camille Gagné ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Convergent Validity ◽  
Leisure Time Physical Activity ◽  
Physical Capacity ◽  
French Canadian ◽  
Validity Indices ◽  
Cardinal Symptom ◽  
Activity Questionnaire

Introduction: Dyspnea is a cardinal symptom among patients with respiratory and cardiovascular diseases. Its underlying mechanisms are complex, including pathophysiological as well as psychological and environmental factors. There is no gold standard to its evaluation and it has been recognized that multidimensional tools could provide a more comprehensive evaluation of the symptom. Hypothesis: The purpose of this study was to examine the validation of the scores of the French-Canadian version of the Modified Dyspnea Index(MDI), a multidimensional measure of dyspnea, among chronic cardiovascular and pulmonary patients. Methods: This study includes 137 patients: 79 with pulmonary arterial hypertension and 58 with interstitial lung disease. The cross-cultural adaptation and reliability of the MDI were already reported. The hypothesis guiding the test of convergent validity were that the final score of MDI, which reflects the intensity of dyspnea and its functional impact, would have correlations with: pulmonary function (forced vital capacity-FVC and FVC%), physical capacity (6 Minutes Walk Test-6MWT and Veterans Specific Activity Questionnaire-VSAQ), the practice of physical activity (Godin-Shephard Leisure-Time Physical Activity Questionnaire - GSLTPAQ) and quality of life (SF-12). Partial correlations were performed controlling theses variables: diagnosis, age, sex, BMI, and schooling. Results: The following correlations were observed between the total score of MDI and the reference variables: FVC 0.36 ( p<0.001 ); FVC% 0.29 ( p=0.008 ); 6MWT 0.58 ( p<0.001 ); VSAQ 0.77 ( p<0.001 ); GSLTPAQ 0.50 ( p<0.001 ); SF12-Physical Component 0.73 ( p<0.001 ); SF12-Mental Comp. 0.31 ( p<0.001 ). Conclusions: The results confirmed the associations hypothesized. The total score of the MDI explained much more the variance of the quality of life and perceived physical capacity, than lung function explained the MDI score. It is aligned with the described impact of the symptom in the daily life of the patient and the complexity of the factors underlying its triggering and perception. The use of the MDI can be very helpful in the clinical follow-up, guiding the choice of the best therapeutic approach and evaluation the outcomes of the interventions implemented.

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