Once-Daily Therapy with Ceftriaxone Compared with Daily Multiple-Dose Therapy with Cefotaxime for Serious Bacterial Infections: A Randomized, Double-Blind Study

1989 ◽  
Vol 160 (3) ◽  
pp. 433-441 ◽  
Author(s):  
L. A. Mandell ◽  
M. G. Bergeron ◽  
A. R. Ronald ◽  
C. Vega ◽  
G. Harding ◽  
...  
Keyword(s):  
Multiple Dose ◽  
Bacterial Infections ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Once Daily ◽  
Dose Therapy ◽  
Serious Bacterial Infections

scholarly journals Pharmacokinetics, Serum Inhibitory and Bactericidal Activity, and Safety of Telavancin in Healthy Subjects

2005 ◽  
Vol 49 (1) ◽  
pp. 195-201 ◽  
Author(s):  
J. P. Shaw ◽  
J. Seroogy ◽  
K. Kaniga ◽  
D. L. Higgins ◽  
M. Kitt ◽  
...  
Keyword(s):  
Steady State ◽  
Bactericidal Activity ◽  
Bacterial Infections ◽  
Area Under The Curve ◽  
Double Blind ◽  
Once Daily ◽  
Elimination Half ◽  
Dose Study ◽  
Serious Bacterial Infections ◽  
State Area

ABSTRACT The pharmacokinetics, tolerability, and serum inhibitory and bactericidal titers of telavancin, a new rapidly bactericidal lipoglycopeptide with multiple mechanisms of action against gram-positive pathogens, were assessed in a two-part, randomized, double-blind, placebo-controlled, ascending-dose study with 54 healthy men. In part 1, single ascending intravenous doses of 0.25 to 15 mg/kg of body weight were studied. In part 2, multiple ascending doses (30-min infusions of 7.5 to 15 mg/kg/day) were studied over 7 days. Following the administration of multiple doses, steady state was achieved by days 3 to 4. At day 7 after the administration of telavancin at 7.5, 12.5, and 15 mg/kg/day, peak concentrations in plasma were 96.7, 151.3, and 202.5 μg/ml, respectively, and steady-state area-under-the-curve values were 700, 1,033, and 1,165 μg · h/ml, respectively. The elimination half-life ranged from 6.9 to 9.1 h following the administration of doses ≥5 mg/kg. Most adverse events were mild in severity. At 24 h postinfusion, serum from subjects given telavancin demonstrated potent bactericidal activity against methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae strains. The results suggest that telavancin may be an effective once-daily therapy for serious bacterial infections caused by these pathogens.

126 Pharmacokinetics, safety and tolerability of multiple-dose cerivastatin in males and females: a double-blind study

1997 ◽  
Vol 130 ◽  
pp. S33 ◽  
Author(s):  
E.A. Stein ◽  
J. Isaacsohn ◽  
M. Zinny ◽  
A. Mazzu ◽  
J. Lettieri ◽  
...  
Keyword(s):  
Multiple Dose ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Males And Females
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