Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases

2007 ◽  
Vol 7 (2) ◽  
pp. 230-240 ◽  
Author(s):  
Jo C. Lewthwaite ◽  
Claire E. Clarkin ◽  
Anthony R.M. Coates ◽  
Stephen Poole ◽  
Rachel A. Lawrence ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases ◽  
Cytokine Production ◽  
Human Monocytes ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
Chaperonin 60 ◽  
Cooperative Activation

scholarly journals Interleukin-8 Secretion from Mycobacterium tuberculosis-Infected Monocytes Is Regulated by Protein Tyrosine Kinases but Not by ERK1/2 or p38 Mitogen-Activated Protein Kinases

2002 ◽  
Vol 70 (8) ◽  
pp. 4743-4746 ◽  
Author(s):  
Clara Ameixa ◽  
Jon S. Friedland
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases ◽  
Tyrosine Kinases ◽  
Nuclear Translocation ◽  
Interleukin 8 ◽  
Protein Tyrosine Kinases ◽  
Human Monocytes ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
Posttranscriptional Processing

ABSTRACT Mycobacterium tuberculosis upregulates NF-κB binding and interleukin-8 (IL-8) gene expression and secretion in primary human monocytes. Inhibition of tyrosine protein kinases but not of ERK1/2 or p38 mitogen-activated protein kinases downregulates tuberculosis-induced IL-8 secretion. The inhibitor genistein decreased NF-κB nuclear translocation and IL-8 gene transcription in addition to acting on posttranscriptional processing.

scholarly journals Phosphorylation of Mitogen-Activated Protein Kinases Contributes to Interferon γ Production in Response to Mycobacterium tuberculosis

2012 ◽  
Vol 207 (2) ◽  
pp. 340-350 ◽  
Author(s):  
Virginia Pasquinelli ◽  
Ana I. Rovetta ◽  
Ivana B. Alvarez ◽  
Javier O. Jurado ◽  
Rosa M. Musella ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases ◽  
Interferon Γ ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein
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