scholarly journals Galectin-3 Regulates the Innate Immune Response of Human Monocytes

2012 ◽  
Vol 207 (6) ◽  
pp. 947-956 ◽  
Author(s):  
Andrew W. Chung ◽  
Peter A. Sieling ◽  
Mirjam Schenk ◽  
Rosane M. B. Teles ◽  
Stephan R. Krutzik ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Human Monocytes ◽  
Galectin 3

scholarly journals Candesartan reduces the innate immune response to lipopolysaccharide in human monocytes

2009 ◽  
Vol 27 (12) ◽  
pp. 2365-2376 ◽  
Author(s):  
Ignacio M Larrayoz ◽  
Tao Pang ◽  
Julius Benicky ◽  
Jaroslav Pavel ◽  
Enrique Sánchez-Lemus ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Human Monocytes

scholarly journals MiR-146b Mediates Endotoxin Tolerance in Human Phagocytes

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Tiziana Ada Renzi ◽  
Marcello Rubino ◽  
Laura Gornati ◽  
Cecilia Garlanda ◽  
Massimo Locati ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Inflammatory Response ◽  
Innate Immune Response ◽  
Endotoxin Tolerance ◽  
Innate Immune ◽  
Human Monocytes ◽  
Key Factors ◽  
Tlr Signaling ◽  
Tolerant State

A proper regulation of the innate immune response is fundamental to keep the immune system in check and avoid a chronic status of inflammation. As they act as negative modulators of TLR signaling pathways, miRNAs have been recently involved in the control of the inflammatory response. However, their role in the context of endotoxin tolerance is just beginning to be explored. We here show that miR-146b is upregulated in human monocytes tolerized by LPS, IL-10, or TGFβpriming and demonstrate that its transcription is driven by STAT3 and RUNX3, key factors downstream of IL-10 and TGFβsignaling. Our study also found that IFNγ, known to revert LPS tolerant state, inhibits miR-146b expression. Finally, we provide evidence that miR-146b levels have a profound effect on the tolerant state, thus candidating miR-146b as a molecular mediator of endotoxin tolerance.

scholarly journals Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Nicholas E. Ilott ◽  
James A. Heward ◽  
Benoit Roux ◽  
Eleni Tsitsiou ◽  
Peter S. Fenwick ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Messenger Rna ◽  
Innate Immune ◽  
Human Monocytes ◽  
Proinflammatory Mediators ◽  
Biological Responses ◽  
Non Coding Rna ◽  
Antisense Lncrnas ◽  
Non Coding Rnas

Abstract Early reports indicate that long non-coding RNAs (lncRNAs) are novel regulators of biological responses. However, their role in the human innate immune response, which provides the initial defence against infection, is largely unexplored. To address this issue, here we characterize the long non-coding RNA transcriptome in primary human monocytes using RNA sequencing. We identify 76 enhancer RNAs (eRNAs), 40 canonical lncRNAs, 65 antisense lncRNAs and 35 regions of bidirectional transcription (RBT) that are differentially expressed in response to bacterial lipopolysaccharide (LPS). Crucially, we demonstrate that knockdown of nuclear-localized, NF-κB-regulated, eRNAs (IL1β-eRNA) and RBT (IL1β-RBT46) surrounding the IL1β locus, attenuates LPS-induced messenger RNA transcription and release of the proinflammatory mediators, IL1β and CXCL8. We predict that lncRNAs can be important regulators of the human innate immune response.

scholarly journals Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Sarah Kim ◽  
Jessica Becker ◽  
Matthias Bechheim ◽  
Vera Kaiser ◽  
Mahdad Noursadeghi ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Genetic Basis ◽  
Innate Immune ◽  
Human Monocytes

scholarly journals Galectin-3 Facilitates Neutrophil Recruitment as an Innate Immune Response to a Parasitic Protozoa Cutaneous Infection

2012 ◽  
Vol 190 (2) ◽  
pp. 630-640 ◽  
Author(s):  
Pampa Bhaumik ◽  
Guillaume St-Pierre ◽  
Valérie Milot ◽  
Christian St-Pierre ◽  
Sachiko Sato
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Neutrophil Recruitment ◽  
Innate Immune ◽  
Cutaneous Infection ◽  
Parasitic Protozoa ◽  
Galectin 3
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