scholarly journals Within-Host Heterogeneity ofMycobacterium tuberculosisInfection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study

2016 ◽  
Vol 213 (11) ◽  
pp. 1796-1799 ◽  
Author(s):  
Ted Cohen ◽  
Leonid Chindelevitch ◽  
Reshma Misra ◽  
Maria E. Kempner ◽  
Jerome Galea ◽  
...  
Keyword(s):  
Cohort Study ◽  
Treatment Response ◽  
Prospective Cohort Study ◽  
Early Treatment ◽  
Prospective Cohort ◽  
Early Treatment Response ◽  
Host Heterogeneity

scholarly journals Early Treatment Outcomes for Bloodstream Infections Caused by Potential AmpC Beta-lactamase-producing Enterobacterales with Focus on Piperacillin/Tazobactam: A Retrospective Cohort Study

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 665
Author(s):  
Lena Herrmann ◽  
Aurelia Kimmig ◽  
Jürgen Rödel ◽  
Stefan Hagel ◽  
Norman Rose ◽  
...  
Keyword(s):  
Cohort Study ◽  
Treatment Outcomes ◽  
Treatment Response ◽  
Sofa Score ◽  
Early Treatment ◽  
Primary Outcome ◽  
Bloodstream Infections ◽  
Beta Lactamase ◽  
Early Treatment Response

The Gram-negative bacilli Serratia spp., Providencia spp., Morganella morganii, Citrobacter freundii complex, Enterobacter spp. and Klebsiella aerogenes are common Enterobacterales that may harbor inducible chromosomal AmpC beta-lactamase genes. The purpose of the present study was to evaluate treatment outcomes and identify predictors of early treatment response in patients with bloodstream infection caused by potential AmpC beta-lactamase-producing Enterobacterales (SPICE-BSI). This cohort study included adult patients with SPICE-BSI hospitalized between 01/2011 and 02/2019. The primary outcome was early treatment response 72 h after the start of active treatment, defined as survival, hemodynamic stability, improved or stable SOFA score, resolution of fever and leukocytosis and microbiologic resolution. Among 295 included patients, the most common focus was the lower respiratory tract (27.8%), and Enterobacter spp. (n = 155) was the main pathogen. The early treatment response rate was significantly lower (p = 0.006) in the piperacillin/tazobactam group (17/81 patients, 21.0%) than in the carbapenem group (40/82 patients, 48.8%). Independent negative predictors of early treatment response (p < 0.02) included initial SOFA score, liver comorbidity and empiric piperacillin/tazobactam treatment. In vitro piperacillin/tazobactam resistance was detected in three patients with relapsed Enterobacter-BSI and initial treatment with piperacillin/tazobactam. In conclusion, our findings show that piperacillin/tazobactam might be associated with early treatment failure in patients with SPICE-BSI.

scholarly journals Exploring the Role of Microbiome in Susceptibility, Treatment Response and Outcome among Tuberculosis Patients from Pakistan; Study Protocol for a Prospective Cohort Study (Micro-STOP)

2021 ◽  
Author(s):  
Muhammad Shahzad ◽  
Zia UlHaq ◽  
Simon C Andrews
Keyword(s):  
Immune Response ◽  
Cohort Study ◽  
Treatment Response ◽  
Prospective Cohort Study ◽  
Gut Microbiome ◽  
Prospective Cohort ◽  
Treatment Success ◽  
Anthropometric Measurement ◽  
Microbiome Diversity ◽  
Study Results

Introduction: Tuberculosis (TB) caused by Mycobacterium tuberculosis is a common infectious disease associated with significant morbidity and mortality, especially in low and middle-income countries. Successful treatment of the disease requires prolonged intake (6 to 8 months) of multiple antibiotics with potentially detrimental consequences on the composition and functional potential of the human microbiome. The protocol described in the current study aims to identify microbiome (oral and gut) signatures associated with TB pathogenesis, treatment response and, outcome in humans. Methods and analysis: Four hundred and fifty, newly diagnosed TB patients from three district levels (Peshawar, Mardan, Swat) TB diagnosis and treatment centers will be recruited in this non-interventional, prospective cohort study and will be followed and monitored until treatment completion. Demographic and dietary intake data, anthropometric measurement and blood, stool and salivary rinse samples will be collected at baseline, day 15, month-2 and end of the treatment. Additionally, we will recruit age and sex-matched healthy controls (n=30). Blood sampling will allow monitoring of the immune response during the treatment, while salivary rinse and fecal samples will allow monitoring of dynamic changes in oral and gut microbiome diversity. Within this prospective cohort study, a nested case-control study design will be conducted to assess perturbations in oral and gut microbiome diversity (microbial dysbiosis) and immune response and compare between the patients groups (treatment success vs failure). Ethics and dissemination The study has received ethics approval from the Ethic Board of Khyber Medical University Peshawar, and administrative approval from the Provincial TB Control Program of Khyber Pakhtunkhwa, Pakistan. The study results will be presented at national and international conferences and published in peer-reviewed journals. Trial registration number: NCT04985994; pre-results

scholarly journals Optimal Histologic Cutpoints for Treatment Response in Patients With Eosinophilic Esophagitis: Analysis of Data From a Prospective Cohort Study

2018 ◽  
Vol 16 (2) ◽  
pp. 226-233.e2 ◽  
Author(s):  
Craig C. Reed ◽  
W. Asher Wolf ◽  
Cary C. Cotton ◽  
Spencer Rusin ◽  
Irina Perjar ◽  
...  
Keyword(s):  
Cohort Study ◽  
Treatment Response ◽  
Prospective Cohort Study ◽  
Eosinophilic Esophagitis ◽  
Prospective Cohort

ROLE OF CD163+ TUMOUR ASSOCIATED MACROPHAGES IN PROGNOSTICATION OF PATIENTS DIAGNOSED OF HODGKIN'S LYMPHOMA: A PROSPECTIVE COHORT STUDY

2021 ◽  
pp. 9-10
Author(s):  
Akshay Sharma ◽  
Anshu Sharma
Keyword(s):  
Cohort Study ◽  
Treatment Response ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Hodgkin’S Lymphoma ◽  
Early Stage ◽  
Univariate Analysis ◽  
Hodgkin's Lymphoma ◽  
End Of Treatment ◽  
Advanced Stages

Hodgkin's lymphoma (HL) constitutes around 30% of all lymphomas . IPS is used for the risk stratication of advanced stage HL but it lack applicability to the early stage cases ..In this prospective cohort study, we aim to conrm the relationship between CD68+TumourAssociated macrophages with treatment response (interim as well as end of treatment) of HL treated with the standard chemotherapy and radiotherapy regimens. A total of 50 patients were recruited over a period of 18 months and the patients were followed up in the hematology clinic and interim treatment responses as well as end of treatment response were assessed. Correlation of the CD163+Tumour Associated Macrophages and the treatment response showed that the Higher Percentages of CD163+Tumour Associated Macrophages were associated with more advanced stages.. Univariate analysis showed that there was no signicant correlation of interim treatment response as well as end of treatment response with CD163+Tumour Associated macrophages levels .

scholarly journals ROLE OF VITAMIN D3 LEVELS IN PROGNOSTICATION OF PATIENTS DIAGNOSED OF HODGKIN'S LYMPHOMA: A PROSPECTIVE COHORT STUDY

2020 ◽  
pp. 1-3
Author(s):  
Akshay Sharma ◽  
Abhimanyu Patial
Keyword(s):  
Cohort Study ◽  
Treatment Response ◽  
Prospective Cohort Study ◽  
Vitamin D3 ◽  
Prospective Cohort ◽  
Hodgkin’S Lymphoma ◽  
Early Stage ◽  
Univariate Analysis ◽  
Hodgkin's Lymphoma ◽  
End Of Treatment

Hodgkin’s lymphoma (HL) constitutes around 30% of all lymphomas(1). IPS is used for the risk stratification of advanced stage HL but it lack applicability to the early stage cases(1)..In this prospective cohort study, we aim to confirm the relationship between vitaminD3 levels with treatment response (interim as well as end of treatment) of HL treated with the standard chemotherapy and radiotherapy regimens. A total of 50 patients were recruited over a period of 18 months and the patients were followed up in the hematology clinic and interim treatment responses as well as end of treatment response were assessed. Correlation of the vitaminD3 levels and the treatment response showed that the low levels of vitaminD3 were associated with more advanced stages. Univariate analysis showed that there was no significant correlation of interim treatment response as well as end of treatment response with vitamin D3 levels.

scholarly journals Usefulness of Automated Latex Turbidimetric Rapid Plasma Reagin Test for Diagnosis and Evaluation of Treatment Response in Syphilis in Comparison with Manual Card Test: a Prospective Cohort Study

2018 ◽  
Vol 56 (11) ◽  
Author(s):  
Motoyuki Tsuboi ◽  
Takeshi Nishijima ◽  
Takahiro Aoki ◽  
Katsuji Teruya ◽  
Yoshimi Kikuchi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Treatment Response ◽  
Prospective Cohort Study ◽  
Predictive Value ◽  
Prospective Cohort ◽  
Dilution Method ◽  
Rapid Plasma Reagin ◽  
Automated Test ◽  
Manual Test ◽  
Card Test

ABSTRACT The usefulness of an automated latex turbidimetric rapid plasma reagin (RPR) assay, compared to the conventional manual card test (serial 2-fold dilution method), for the diagnosis of syphilis and evaluation of treatment response remains unknown. We conducted (i) a cross-sectional study and (ii) a prospective cohort study to elucidate the correlation between automated and manual tests and whether a 4-fold decrement is a feasible criterion for successful treatment with the automated test, respectively, in HIV-infected patients, from October 2015 to November 2017. Study i included 518 patients. The results showed strong correlation between the two tests (r = 0.931; P < 0.001). With a manual test titer of ≥1:8 plus a positive Treponema pallidum particle agglutination (TPPA) test as the reference standard for diagnosis, the optimal cutoff value for the automated test was 6.0 RPR units (area under the curve [AUC], 0.998), with positive predictive value (PPV) of 92.5% and negative predictive value (NPV) of 99.4%. Study ii enrolled 66 men with syphilis. Their RPR values were followed up until after 12 months of treatment. At 12 months, 77.3% and 78.8% of the patients achieved a 4-fold decrement in RPR titer by the automated and manual test, respectively. The optimal decrement rate in RPR titer by the automated test for a 4-fold decrement by manual card test was 76.54% (AUC, 0.96) (PPV, 96.1%; NPV, 80.0%). The automated RPR test is a good alternative to the manual test for the diagnosis of syphilis and evaluation of treatment response and is more rapid and can handle more specimens than the manual test without interpersonal variation in interpretation.

scholarly journals Comparison of Treatment Response and Survival Profiles Between Drug-Eluting Bead Transarterial Chemoembolization and Conventional Transarterial Chemoembolization in Chinese Hepatocellular Carcinoma Patients: A Prospective Cohort Study

2019 ◽  
Vol 27 (5) ◽  
pp. 583-592 ◽  
Author(s):  
Ping Wen ◽  
Sheng-Duo Chen ◽  
Jia-Rui Wang ◽  
Ying-He Zeng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Regression Analysis ◽  
Cohort Study ◽  
Treatment Response ◽  
Prospective Cohort Study ◽  
Predictive Factor ◽  
Prospective Cohort ◽  
Transarterial Chemoembolization ◽  
Multivariate Logistic Regression Analysis ◽  
Drug Eluting

This study evaluated the difference in treatment response and survival profiles between drug-eluting bead transarterial chemoembolization (DEB-TACE) and conventional transarterial chemoembolization (cTACE) treatments in Chinese hepatocellular carcinoma (HCC) patients. A total of 120 HCC patients were consecutively enrolled in this prospective cohort study, which showed that DEB-TACE achieved higher complete response (CR) (30.8%) compared with cTACE (7.4%) with no difference in overall response rate (ORR) for patients treated with DEB-TACE and cTACE (80.8% vs. 73.5%). In addition, DEB-TACE was associated with a lower rate of progressive disease (PD) compared with cTACE (1.9% vs. 11.8%). With respect to survival, patients in the DEB-TACE group achieved median progression-free survival (PFS) of 15 months (95% CI 12‐18 months), which was longer than the cTACE group [median PFS 11 months (95% CI 10‐12 months)]. Median overall survival (OS) was also longer with DEB-TACE [25 months (95% CI 22-28 months)] when compared with cTACE [21 months (95% CI 18‐24 months)]. Univariate and multivariate logistic regression analysis showed that DEB-TACE was an independent predictive factor for achieving CR. Univariate Cox’s regression analysis revealed that DEB-TACE was a predictive factor for prolonged PFS and OS, while multivariate analysis demonstrated that DEB-TACE was not an independent factor for predicting PFS or OS. In conclusion, we found that DEB-TACE achieved higher treatment response and prolonged survival compared with cTACE in Chinese HCC patients.

ROLE OF SERUM LDH LEVELS IN PROGNOSTICATION OF PATIENTS DIAGNOSED OF HODGKIN'S LYMPHOMA: A PROSPECTIVE COHORT STUDY

2021 ◽  
pp. 13-15
Author(s):  
Akshay Sharma ◽  
Anshu Sharma
Keyword(s):  
Cohort Study ◽  
Treatment Response ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Hodgkin’S Lymphoma ◽  
Early Stage ◽  
Univariate Analysis ◽  
Hodgkin's Lymphoma ◽  
End Of Treatment ◽  
Advanced Stages

Hodgkin's lymphoma (HL) constitutes around 30% of all lymphomas . IPS is used for the risk stratication of advanced stage HL but it lack applicability to the early stage cases ..In this prospective cohort study, we aim to conrm the relationship between hsCRP levels with treatment response (interim as well as end of treatment) of HL treated with the standard chemotherapy and radiotherapy regimens. A total of 50 patients were recruited over a period of 18 months and the patients were followed up in the hematology clinic and interim treatment responses as well as end of treatment response were assessed. Correlation of the serum LDH levels and the treatment response showed that the low levels of serum LDH level were associated with more advanced stages.. Univariate analysis showed that there was no signicant correlation of interim treatment response as well as end of treatment response with serum LDH levels .

Sign in / Sign up

Export Citation Format

Share Document