scholarly journals In vitro antifungal activity and in vivo antibiofilm activity of cerium nitrate against Candida species

2015 ◽  
Author(s):  
A. Silva-Dias ◽  
I. M. Miranda ◽  
J. Branco ◽  
L. Cobrado ◽  
M. Monteiro-Soares ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Candida Species ◽  
Cerium Nitrate ◽  
Antibiofilm Activity ◽  
In Vitro Antifungal Activity

In vitro antifungal activity of the flavonoid baicalein against Candida species

2012 ◽  
Vol 61 (12) ◽  
pp. 1704-1708 ◽  
Author(s):  
Rosana Serpa ◽  
Emanuele J. G. França ◽  
Luciana Furlaneto-Maia ◽  
Célia G. T. J. Andrade ◽  
Andréa Diniz ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Candida Species ◽  
In Vitro Antifungal Activity

scholarly journals In vitro antifungal activity against Candida species of Sri Lankan orthodox black tea (Camellia sinensis L.) belonging to different agro-climatic elevations

2017 ◽  
Vol 5 (2) ◽  
pp. 66-69 ◽  
Author(s):  
Wanigasekara Daya Ratnasooriya ◽  
◽  
Sachitra Gayanthi Ratnasooriya ◽  
Chatura Dayendra Tissa Ratnasooriya ◽  
Ranga Dissanayake ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Camellia Sinensis ◽  
Candida Species ◽  
Black Tea ◽  
Sri Lankan ◽  
In Vitro Antifungal Activity

scholarly journals In vitro Antifungal Activity of Plant Extracts, Hydrolates and Essential Oils of Some Medicinal Plants and Control of Cucumber Anthracnose

2019 ◽  
pp. 1-9
Author(s):  
Amanda P. Mattos ◽  
Fabricio P. Povh ◽  
Bruna B. Rissato ◽  
Vítor V. Schwan ◽  
Kátia R. F. Schwan-Estrada
Keyword(s):  
Antifungal Activity ◽  
Medicinal Plants ◽  
Curcuma Longa ◽  
Sclerotium Rolfsii ◽  
Phytopathogenic Fungi ◽  
In Vivo Test ◽  
Activity Effect ◽  
In Vitro Antifungal Activity

Aims: This study is aimed to evaluate the in vitro antifungal activity effect of the crude aqueous extract (CAE), hydrolate (HY) and essential oil (EO) of Corymbia citriodora, Cymbopogon citratus, Cymbopogon flexuosus and Curcuma longa against the phytopathogenic fungi Alternaria steviae, Botryosphaeria dothidea, Colletotrichum gloeosporioides and Sclerotium rolfsii, and assess, in situ, the effectiveness of CAE of medicinal plants in reducing the severity of the cucumber anthracnose. Methodology: The EOs and HYs were obtained by hydrodistillation. The CAEs were prepared by the turbolysis method. Mycelial growth of the fungi was measured daily, by the diametrically opposite method. In the in vivo test, the CAEs were sprayed on the cotyledon leaves of healthy cucumber plants with three days after were inoculated with C. lagenarium. The severity of assessment of the disease was based on a scale of notes. Results: The medicinal plants studied showed antifungal activity against all or almost all pathogens. In general, treatment with CAE and HY of C. longa revealed the highest inhibition against the fungi tested. With the exception of the EO of C. longa, the other EOs showed total inhibition against all the fungi and in all the concentrations tested. Compared to control, in in vivo assays CAE of C. citratus presents a potential for control of cucumber anthracnose reducing the severity of the disease. Conclusion: The medicinal plants studied produce compounds associated with antimicrobial activity.

scholarly journals Antifungal Activity of an Original Amino-Isocyanonaphthalene (ICAN) Compound Family: Promising Broad Spectrum Antifungals

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 903
Author(s):  
Miklós Nagy ◽  
Gábor Szemán-Nagy ◽  
Alexandra Kiss ◽  
Zsolt László Nagy ◽  
László Tálas ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Candida Species ◽  
Fungal Pathogens ◽  
Clinical Strain ◽  
Control Group ◽  
Multiple Drug ◽  
Species Structure ◽  
In Vivo Experiments

Multiple drug resistant fungi pose a serious threat to human health, therefore the development of completely new antimycotics is of paramount importance. The in vitro antifungal activity of the original, 1-amino-5-isocyanonaphthalenes (ICANs) was evaluated against reference strains of clinically important Candida species. Structure-activity studies revealed that the naphthalene core and the isocyano- together with the amino moieties are all necessary to exert antifungal activity. 1,1-N-dimethylamino-5-isocyanonaphthalene (DIMICAN), the most promising candidate, was tested further in vitro against clinical isolates of Candida species, yielding a minimum inhibitory concentration (MIC) of 0.04–1.25 µg/mL. DIMICAN was found to be effective against intrinsically fluconazole resistant Candida krusei isolates, too. In vivo experiments were performed in a severly neutropenic murine model inoculated with a clinical strain of Candida albicans. Daily administration of 5 mg/kg DIMICAN intraperitoneally resulted in 80% survival even at day 13, whereas 100% of the control group died within six days. Based on these results, ICANs may become an effective clinical lead compound family against fungal pathogens.

In vitro antifungal activity of phenothiazines and their combination with amphotericin B against different Candida species

Mycoses ◽  
2011 ◽  
Vol 54 (6) ◽  
pp. e737-e743 ◽  
Author(s):  
László Galgóczy ◽  
Andrea Bácsi ◽  
Mónika Homa ◽  
Máté Virágh ◽  
Tamás Papp ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Candida Species ◽  
In Vitro Antifungal Activity

scholarly journals Strong Antifungal Activity of SS750, a New Triazole Derivative, Is Based on Its Selective Binding Affinity to Cytochrome P450 of Fungi

2002 ◽  
Vol 46 (2) ◽  
pp. 308-314 ◽  
Author(s):  
Masaru Matsumoto ◽  
Kazuya Ishida ◽  
Akihiro Konagai ◽  
Kazunori Maebashi ◽  
Takemitsu Asaoka
Keyword(s):  
Cytochrome P450 ◽  
Antifungal Activity ◽  
In Vivo Studies ◽  
Dependent Manner ◽  
Strong Affinity ◽  
Dose Dependent ◽  
Potent Inhibitory Activity ◽  
In Vitro Antifungal Activity

ABSTRACT SS750 [(R)-(−)-2-(2,4-difluorophenyl)-1-(ethylsulfonyl)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-2-propanol] is a new triazole, and its potential as an antifungal agent was evaluated by in vitro and in vivo studies. In a comparison of the MICs at which 50% of isolates are inhibited (MIC50s) for all strains of Candida species and Cryptococcus neoformans tested, SS750 was four times or more active than fluconazole and had activity comparable to that of itraconazole. The most important advantage of SS750 was that, when the MIC90s were compared, SS750 had 64 and 32 times greater antifungal activities than fluconazole against Candida krusei and Candida glabrata, respectively, which are intrinsically less susceptible to fluconazole. In cyclophosphamide-immunosuppressed mouse models of systemic and pulmonary candidiasis caused by C. albicans, oral SS750 prolonged the number of days of survival of infected animals in a dose-dependent manner and was 4 and ≥64 times more potent than fluconazole and itraconazole, respectively. In a safety profile, SS750, like fluconazole, had less of an affinity for binding to mammalian cytochrome P450 compared with that of ketoconazole, despite its strong affinity for binding to fungal cytochrome P450. The mechanism for the increased in vitro antifungal activity of SS750 against C. krusei is partially due to the potent inhibitory activity (3.7 times versus that of fluconazole) of C. krusei cytochrome P450 sterol 14α-demethylase; SS750 showed a strong affinity for binding to cytochrome P450 of C. krusei, indicating that SS750 acts by inhibiting the cytochrome P450 sterol 14α-demethylase of fungal cells.

scholarly journals In Vitro Antifungal Activity of a Medicinal Plant Extract Mixture Against Candida Species Isolated from Patients with Oral Stomatitis

2019 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Gonca Erkose Genc ◽  
Ozcan Sahinkaya ◽  
Candan Demir ◽  
Ozgul Kisa ◽  
Dilek Satana
Keyword(s):  
Antifungal Activity ◽  
Medicinal Plant ◽  
Plant Extract ◽  
Candida Species ◽  
In Vitro Antifungal Activity

In vitro antifungal activity of silver nanoparticles against fluconazole-resistant Candida species

2015 ◽  
Vol 31 (11) ◽  
pp. 1801-1809 ◽  
Author(s):  
Jhon J. Artunduaga Bonilla ◽  
Daissy J. Paredes Guerrero ◽  
Clara I. Sánchez Suárez ◽  
Claudia C. Ortiz López ◽  
Rodrigo G. Torres Sáez
Keyword(s):  
Silver Nanoparticles ◽  
Antifungal Activity ◽  
Candida Species ◽  
Fluconazole Resistant ◽  
In Vitro Antifungal Activity
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