The Reference Range for the Anion Gap Is Dependent on the Instrument’s Electrolyte Assay

2021 ◽  
Author(s):  
Alan H B Wu ◽  
Tyler Jankowski ◽  
Yu Zhang ◽  
Kara L Lynch
Keyword(s):  
Reference Range ◽  
Anion Gap

scholarly journals 88: Reassessment of Anion Gap Reference Range Following Implementation of New Chemistry Analyzers: The Fairview Experience

2015 ◽  
Vol 143 (suppl_1) ◽  
pp. A051-A051
Author(s):  
Rajeevan Selvaratnam ◽  
Jing Cao ◽  
Danni Li ◽  
Amy B. Karger
Keyword(s):  
Reference Range ◽  
Anion Gap

scholarly journals Preanalytic Effects on Anion Gap—Reference Range Modification

2018 ◽  
Vol 150 (suppl_1) ◽  
pp. S63-S63
Author(s):  
Aisha Fatima ◽  
Mary Carayannopoulos
Keyword(s):  
Reference Range ◽  
Anion Gap

scholarly journals Transient 5-oxoprolinuria and high anion gap metabolic acidosis: clinical and biochemical findings in eleven subjects

1998 ◽  
Vol 44 (7) ◽  
pp. 1497-1503 ◽  
Author(s):  
James J Pitt ◽  
Simon Hauser
Keyword(s):  
Metabolic Acidosis ◽  
Organic Acids ◽  
Organic Acid ◽  
Clinical Features ◽  
Reference Range ◽  
Anion Gap ◽  
Urinary Organic Acid ◽  
Liver Glutathione ◽  
Liver Functions

Abstract We describe biochemical and clinical features of 11 subjects (ages, 1.2–84 years, nine females and two males) with transient 5-oxoprolinuria (0.6–23.6 mol/mol of creatinine, reference range <0.07). A variety of conditions preceded the onset of acidosis, and all had taken acetaminophen (paracetamol), although in therapeutic amounts in most subjects. Metabolic acidosis was documented in nine subjects, and all had an increased anion gap and abnormal liver functions. 5-Oxoproline was the major urinary organic acid in five subjects, whereas the rest had more complex profiles comprising 5-oxoproline and other organic acids, such as lactate, 3-hydroxybutyrate, and 4-hydroxyphenyl lactate. The 5-oxoproline was predominantly of the l-configuration. One subject died during an acidotic episode, and the rest recovered with no apparent long-term ill effects. Urinary 5-oxoproline was within the reference range in six subjects that were re-tested after the anion gap normalized. These findings suggest that acetaminophen, in association with other unidentified factors, is involved in the development of this condition through a mechanism of depletion of liver glutathione stores.

Umbilical artery time-averaged maximum velocity: First trimester reference range

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
SK Amylidi ◽  
P Tappeser ◽  
B Mosimann ◽  
J Zdanowicz ◽  
M Baumann ◽  
...  
Keyword(s):  
Umbilical Artery ◽  
Reference Range ◽  
Maximum Velocity ◽  
First Trimester

Effects of Age and Health on the Euthyroid Reference Ranges for Serum Free Thyroxine and Free Triiodothyronine

1985 ◽  
Vol 24 (02) ◽  
pp. 57-65 ◽  
Author(s):  
J. E. M. Midgley ◽  
K. R. Gruner
Keyword(s):  
Lower Limit ◽  
Healthy Subjects ◽  
Thyroid Dysfunction ◽  
Reference Range ◽  
Free Thyroxine ◽  
Reference Ranges ◽  
Free Triiodothyronine ◽  
Serum Free ◽  
Young Subjects ◽  
Age Range

SummaryAge-related trends in serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations were measured in 7248 euthyroid subjects (age-range 3 months to 106 years). 5700 were patients referred to hospitals for investigation of suspected thyroid dysfunction, but who were diagnosed euthyroid. 1548 were healthy blood donors (age-range 18-63 years) with no indication of thyroid dysfunction. FT4 concentrations were little affected by the age, the sex or the state of health of the subjects in either group. Serum FT3 concentrations were significantly affected by both age and health factors. The upper limit of the euthyroid reference range for young subjects up to 15 years was about 20% higher (10.4 pmol/1) than for adult subjects older than 25 years (8.8 pmol/1). The change in the upper limits typical of young subjects to that typical of adults occurred steadily over the decade 15–25 years. After this age, little further change occurred, especially in healthy subjects. Additionally, the lower limit of the euthyroid range for FT3 was extended by the inclusion in the reference group of patients referred to hospitals. Compared with the lower limit of the FT3 range for healthy subjects (5 pmol/1), the corresponding limit for referred subjects (young or adult) was 3.5–3.8 pmol/1. Broadening of the FT3 reference range was probably brought about by a significant number of patients in the hospital-referred group with the “1OW-T3 syndrome” of mild non-thyroidal illness. Accordingly, FT3 was inferior to FT4 in the discrimination of hypothyroidism, as FT4 was unaffected by this phenomenon. Effects of age and non-thyroidal illness on serum FT3 concentrations require great care when selecting subjects for a laboratory euthyroid reference range typical of the routine workload. Constraints on the choice of subjects for FT4 reference ranges are less stringent.

Evaluation of normal reference range for thyroid uptake of technetium-99 m in a single centre UK population

2017 ◽  
Author(s):  
Mavin Macauley ◽  
Mohamed Shagwi ◽  
Kim Howe ◽  
Andrew Curry ◽  
Elizabeth Howell ◽  
...  
Keyword(s):  
Reference Range ◽  
Single Centre ◽  
Normal Reference Range ◽  
Normal Reference ◽  
Thyroid Uptake

Low free T3 levels within the reference range independently predict cardiovascular mortality in the general population

2018 ◽  
Author(s):  
Joao Sergio Neves ◽  
Catarina Viegas Dias ◽  
Lia Leitao ◽  
Miguel Bigotte Vieira ◽  
Rita Magrico ◽  
...  
Keyword(s):  
General Population ◽  
Cardiovascular Mortality ◽  
Reference Range ◽  
Free T3

An Unusual Case of Severe Anion Gap Metabolic Acidosis in a 3-year-old Girl

2021 ◽  
Vol 42 (Supplement 1) ◽  
pp. S46-S51
Author(s):  
Ryan M. Fredericks ◽  
George Sam Wang ◽  
Christine U. Vohwinkel ◽  
Jessica Kraynik Graham
Keyword(s):  
Metabolic Acidosis ◽  
Unusual Case ◽  
Anion Gap

Could Thyroid Disorders Be Better Understood and Dealt as a Thyroid Syndrome

2020 ◽  
Vol 5 (08) ◽  
pp. 326-328
Author(s):  
Dr. Sushma Patil ◽  
Dr. Vikrant Patil
Keyword(s):  
Reference Range ◽  
Well Being ◽  
Thyroid Disorders ◽  
Thyroid Function Tests ◽  
Thyroid Disorder ◽  
Serum Concentrations ◽  
Comorbid Conditions ◽  
Free T4 ◽  
Research Perspective ◽  
Wide Range

Thyroid disorders are common worldwide. Thyroid dysfunction, both hypo- and hyperthyroidism may increase the risk of cardiovascular disorders. Current thyroid function tests may have limitations since they only measure the total or free T4 and/or T3 and TSH serum concentrations in peripheral blood and not the effect of T4 or T3 serum on different specific target tissues. Several comorbid conditions can interfere with the absorption or increase the clearance of levothyroxine. Among patients treated with thyroid replacement, under or overmedicated may-be at risk for adverse health consequences. A wide range of drugs may interfere with levothyroxine absorption, metabolism, and action. Patients report a lack of well-being, despite reaching euthyroid reference range of TSH, with psychological distress. If we will consider Thyroid related conditions as a syndrome then research perspective at the pathophysiology, interrelation between symptoms and comorbidities will be much broader that can lead researchers to get insights of different pathways in which thyroid gland functioning can be perceived and dealt therapeutically. The deliberation of thyroid disorder as a syndrome can affluence our knowledge of correlating cofounders, action of thyroid hormones on target tissues, underlying cause and thyroid health.

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